A gastrotomy tube stabilizer comprises an upper, dome-shaped shell and a lower, cup-shaped shell. The lower shell remains affixed to the patient's skin and has a central aperture sufficiently large to permit passage of the gastrotomy tube therethrough and to leave the surrounding wound area exposed. The upper shell has a collar extending upwardly therefrom adapted to retain the gastrotomy tube, and is furnished with plural holes for ventilation. The upper and lower shells are furnished with cooperating interlocking means. When the shells are joined, a protective cavity is formed surrounding the wound area and the position of the gastrotomy tube is maintained. The upper shell may be readily disengaged from the lower shell to afford visual inspection of the wound area and access thereto for cleaning and changing of dressings.