Ruth Margrit Ruprecht

Address:

503 Ave A APT 1303, San Antonio, TX 78215

VIN:

JHLRE48767C030701

Make:

HONDA

Model:

CR-V

Year:

2007

US Patent:

8603490, Dec 10, 2013

Filed:

Sep 29, 2008

Appl. No.:

12/286159

Inventors:

Ruth M. Ruprecht - Boston MA, US

Assignee:

Dana-Farber Cancer Institute, Inc. - Boston MA

International Classification:

A61K 39/21
C07H 21/04

US Classification:

4242081, 4241991, 536 2372

Abstract:

The invention provides methods and compositions for raising an immune response in a subject by administering an HIV antigen. The HIV antigens include HIV clade C polynucleotides and polypeptides. The invention also provides for recombinant HIV viral particles and compositions.

US Patent:

20050208599, Sep 22, 2005

Filed:

Jan 18, 2005

Appl. No.:

11/039075

Inventors:

Ruth Ruprecht - Brookline MA, US

Assignee:

Dana-Farber Cancer Institute, Inc. - Boston MA

International Classification:

G01N033/567
C12N005/08

US Classification:

435007210, 435372000

Abstract:

The present invention is based, at least in part, on methods to select pure and functional dendritic cells from a heterogeneous population of cells. Accordingly, the invention features a method of selecting dendritic cells from a heterogeneous population of cells comprising contacting said cells with an antibody against dendritic cell-specific adhesion receptor (DC-SIGN), preferably DCN46, or a fragment thereof, and identifying dendritic cells based on binding of said antibody to said cells, thereby selecting dendritic cells from a heterogeneous population of cells.

US Patent:

20050249742, Nov 10, 2005

Filed:

Dec 22, 2004

Appl. No.:

11/022562

Inventors:

Ruth Ruprecht - Brookline MA, US
Shisong Jiang - Chestnut Hill MA, US

Assignee:

Dana-Farber Cancer Institute, Inc. - Boston MA

International Classification:

A61K039/385
A61K039/00

US Classification:

424185100

Abstract:

The present invention provides compositions and methods for the treatment and prevention of immune disorders.

US Patent:

20120082643, Apr 5, 2012

Filed:

Jul 11, 2011

Appl. No.:

13/180459

Inventors:

RUTH M. RUPRECHT - BROOKLINE MA, US
SHISONG JIANG - CHESTNUT HILL MA, US

Assignee:

DANA-FARBER CANCER INSTITUTE, INC. - BOSTON MA

International Classification:

A61K 39/39
A61K 39/21
A61K 39/07
A61K 39/12
A61K 39/29
A61K 39/155
A61K 39/015
A61K 39/085
A61K 39/112
A61K 39/108
A61K 39/08
A61K 39/10
A61K 39/215
A61P 37/04
A61P 31/18
A61P 31/14
A61P 35/00
A61P 31/04
A61P 33/06
A61K 39/00

US Classification:

424 852, 4241841, 4241881, 4241901, 4241861, 4241851, 4241911

Abstract:

The present invention provides compositions and methods for the treatment and prevention of immune disorders.

US Patent:

20120148594, Jun 14, 2012

Filed:

Aug 23, 2010

Appl. No.:

13/391498

Inventors:

Michael Humbert - Boston MA, US
Ruth M. Ruprecht - Brookline MA, US
Anton M. Sholukh - Allston MA, US

Assignee:

DANA-FARBER CANCER INSTITUTE, INC. - Boston MA

International Classification:

A61K 39/395
A61K 39/12
A61K 39/02
A61K 39/002
C12Q 1/02
C12N 5/10
C12N 5/00
C12N 1/21
C12N 1/19
C12N 15/63
A61K 38/00
A61K 31/7088
C07K 7/08
C07K 7/06
C07K 16/00
C07H 21/04
A61P 33/00
A61P 33/02
A61P 31/04
A61P 31/10
A61P 37/04
A61P 31/12
A61K 39/00

US Classification:

4241391, 4241841, 4241851, 4242041, 4242341, 4242651, 4242741, 435 29, 435325, 435348, 4352523, 43525231, 43525233, 43525235, 43525421, 4353201, 514 11, 514 44 R, 530327, 530329, 5303879, 5303881, 536 231

Abstract:

The invention provides methods, compositions and kits for treating and or preventing diseases having immunological components associated with their etiology and/or progression (e.g., an HIV infection). A mimotope that mimics an epitope of an antigen may be administered to an individual to induce or enhance an immune response for the treatment of a disease. For example, HIV envelope-like polypeptides (wild-type HIV polypeptides and mimotopes) may be administered to an individual so as to induce a protective immune response to HIV. Alternatively, antibodies directed to a mimotope may be administered to an individual to treat or prevent a disease. Antibodies directed to HIV envelope-like polypeptides may be administered to an individual to treat or prevent an HIV infection and/or one or more symptoms associated with the infection (e.g., AIDS). In another embodiment, the invention provides compositions and methods for isolating an epitope specific B cell.

US Patent:

20120183533, Jul 19, 2012

Filed:

Mar 30, 2011

Appl. No.:

13/075761

Inventors:

Ruth M. Ruprecht - Brookline MA, US
Michael Humbert - Boston MA, US

International Classification:

A61K 39/42
C07K 19/00
C07K 7/08
A61K 39/21
C12N 15/49
C12N 1/19
C07K 16/10
A61P 31/18
C12N 5/10
A61P 37/04
C12N 1/21
C07K 7/06
C12N 15/63

US Classification:

4241331, 530329, 530327, 4241881, 536 2372, 4353201, 5303879, 5303873, 4241391, 435331, 43525233, 435325, 435348, 435419, 4352542, 4352523

Abstract:

The invention provides methods, compositions and kits for treating and or preventing an HIV infection. For example, HIV envelope-like polypeptides (wild-type HIV polypeptides and mimotopes) may be administered to an individual so as to induce a protective immune response to HIV. Alternatively, antibodies directed to the HIV envelope-like polypeptides may be administered to an individual to treat or prevent an HIV infection and/or one or more symptoms associated with the infection (e.g., AIDS).

US Patent:

20140037619, Feb 6, 2014

Filed:

Jun 10, 2013

Appl. No.:

13/914252

Inventors:

Ruth M. Ruprecht - Brookline MA, US
Michael Humbert - Boston MA, US

Assignee:

DANA-FARBER CANCER INSTITUTE - Boston MA

International Classification:

C07K 14/005
C07K 16/10

US Classification:

4241331, 530350, 530327, 530329, 4241881, 536 2353, 4353201, 5303879, 5303873, 4241391, 435331, 43525233, 43525231, 4352523, 43525421, 43525422, 4352542, 43525423

Abstract:

The invention provides methods, compositions and kits for treating and or preventing an HIV infection. For example, HIV envelope-like polypeptides (wild-type HIV polypeptides and mimotopes) may be administered to an individual so as to induce a protective immune response to HIV. Alternatively, antibodies directed to the HIV envelope-like polypeptides may be administered to an individual to treat or prevent an HIV infection and/or one or more symptoms associated with the infection (e.g., AIDS).

US Patent:

51324148, Jul 21, 1992

Filed:

May 10, 1990

Appl. No.:

7/521748

Inventors:

Andre Rosowsky - Needham MA
Ruth M. Ruprecht - Boston MA

Assignee:

Dana-Farber Cancer Institute, Inc. - Boston MA

International Classification:

C07H 1900

US Classification:

536 27

Abstract:

Compounds having the structure ##STR1## in which R is alkyl, aryl, or aralkyl, A is hydrogen or a water-soluble cation, B is hydrogen, fluorine, or azido, the bond is saturated when B is fluorine or azido and is saturated or unsaturated when B is hydrogen, and D is a purine or pyrimidine base are effective inhibitors of retrovirus replication.