Ruth Ann Vrable from Gwinn, MI, age 75

Vaccine To Control Equine Protozoal Myeloencephalitis In Horses
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US Patent:

7390492, Jun 24, 2008
Filed:

Sep 26, 2000
Appl. No.:

09/669833
Inventors:

Linda S. Mansfield - Bath MI, US
Mary G. Rossano - Mason MI, US
Alice J. Murphy - St. Johns MI, US
Ruth A. Vrable - Williamston MI, US
Assignee:

Board of Trustees of Michigan State University - East Lansing MI
International Classification:

A61K 39/002
A61K 39/00
A61K 38/00
US Classification:

4241781, 4241841, 4242651, 514 2
Abstract:

The present invention provides vaccines and methods for making the vaccines that actively or passively protect an equid or other animal against In particular, the present invention provides vaccines that provide active immunity which comprise a polypeptide or DNA vaccine that contains or expresses at least one epitope of an antigen that has an amino acid sequence substantially similar to a unique 16 (4) kDa antigen and/or 30 (4) kDa antigen of The present invention further provides a vaccine that provides passive immunity to comprising polyclonal or monoclonal antibodies against at least one epitope of an antigen substantially similar to a unique 16 (4) kDa antigen and/or 30 (4) kDa antigen of.

Vaccine To Control Equine Protozoal Myeloencephalitis In Horses
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US Patent:

7419668, Sep 2, 2008
Filed:

Feb 24, 2000
Appl. No.:

09/513086
Inventors:

Linda S. Mansfield - Bath MI, US
Mary G. Rossano - Mason MI, US
Alice J. Murphy - St. Johns MI, US
Ruth A. Vrable - Williamston MI, US
Assignee:

Board of Trustees of Michigan State University - East Lansing MI
International Classification:

A61K 39/00
A61K 39/38
US Classification:

4241841, 4242691
Abstract:

The present invention provides vaccines and methods for making the vaccines that actively or passively protect an equid or other animal against. In particular, the present invention provides vaccines that provide active immunity which comprise a polypeptide or DNA vaccine that contains or expresses at least one epitope of an antigen that has an amino acid sequence substantially similar to a unique 16 (4) kDa antigen and/or 30 (4) kDa antigen of. The present invention further provides a vaccine that provides passive immunity to comprising polyclonal or monoclonal antibodies against at least one epitope of an antigen substantially similar to a unique 16 (4) kDa antigen and/or 30 (4) kDa antigen of.

Vaccine To Control Equine Protozoal Myeloencephalitis In Horses
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US Patent:

7510720, Mar 31, 2009
Filed:

Sep 26, 2000
Appl. No.:

09/670096
Inventors:

Linda S. Mansfield - Bath MI, US
Mary G. Rossano - Mason MI, US
Alice J. Murphy - St. Johns MI, US
Ruth A. Vrable - Williamston MI, US
Assignee:

Board of Trustees of Michigan State University - East Lansing MI
International Classification:

A61K 39/002
A61K 38/00
US Classification:

4242651, 4241841, 4241781, 514 2, 514 44
Abstract:

The present invention provides vaccines and methods for making the vaccines that actively or passively protect an equid or other animal against Sarcocystis neurona. In particular, the present invention provides vaccines that provide active immunity which comprise a polypeptide or DNA vaccine that contains or expresses at least one epitope of an antigen that has an amino acid sequence substantially similar to a unique 16 (4) kDa antigen and/or 30 (4) kDa antigen of Sarcocystis neurona. The present invention further provides a vaccine that provides passive immunity to Sarcocystis neurona comprising polyclonal or monoclonal antibodies against at least one epitope of an antigen substantially similar to a unique 16 (4) kDa antigen and/or 30 (4) kDa antigen of Sarcocystis neurona.

Antigen Test To Detect Equine Protozoal Myeloencephalitis In Horse Serum And Cerebrospinal Fluid
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US Patent:

6344337, Feb 5, 2002
Filed:

Feb 18, 2000
Appl. No.:

09/506630
Inventors:

Linda S. Mansfield - Bath MI
Mary G. Rossano - Mason MI
Alice J. Murphy - St. Johns MI
Ruth A. Vrable - Williamston MI
Assignee:

Board of Trustees of Michigan State University - East Lansing MI
International Classification:

G01N 3353
US Classification:

435 72, 435 34, 5303886
Abstract:

The present invention provides an immunoassay to detect identifying antigens in horses that are infected with. The immunoassay is preferably an antigen-capture-based assay that relies upon polyclonal or monoclonal antibodies against a 16 (Â4) and/or 30 (Â4) kDa antigens specific to Sarcocystis neurona to detect the presence of the 16 (Â4) and/or 30 (Â4) kDa antigens in equine serum or equine cerebrospinal fluid.

Ruth Ann Vrable