Astrazeneca
Associate Director, Translational Medicine, Oncology R and D
Foundation Medicine Dec 2015 - Jan 2018
Senior Scientist
University of Pittsburgh Aug 2014 - Dec 2015
Research Instructor
University of Pittsburgh Nov 2010 - Aug 2014
Postdoctoral Associate
Baylor College of Medicine Aug 2005 - Oct 2010
Graduate Student
Education:
Baylor College of Medicine 2005 - 2010
Doctorates, Doctor of Philosophy, Biology, Philosophy, Medicine
University of Washington 2001 - 2005
Bachelors, Bioengineering
Skills:
Molecular Biology Cancer Tissue Culture Cell Culture Genetics Molecular Cloning Bioinformatics Cancer Research Qpcr Pcr Genomics Dna Sequencing Mouse Models Western Blotting Rt Pcr Polymerase Chain Reaction Ngs Unix Perl Ngs Sequencing Analysis Sequence Analysis Mate Pair Sequencing Genome Sequencing Python Mysql Microscopy Flow Cytometry Mouse Handling Immunoprecipitation Chromatin Immunoprecipitation Transfection Protein Expression Site Directed Mutagenesis Cancer Cell Biology Imagej
Steffi Oesterreich - Missouri City TX, US Alexandra Richter - Houston TX, US Adrian Lee - Missouri City TX, US C. Kent Osborne - Houston TX, US Sean E. Mcguire - Houston TX, US Ryan Hartmaier - Houston TX, US
Assignee:
BAYLOR COLLEGE OF MEDICINE - Houston TX
International Classification:
C12Q 1/68 C12Q 1/48
US Classification:
435 6, 435 15
Abstract:
Osteoporosis is a common skeletal disease characterized by loss of bone mineral density (BMD) and increased risk of fracture. Osteoporosis most commonly occurs in postmenopausal women due to estrogen deficiency. We identified 3 genetic variants in steroid receptor coactivator 1 (SRC-1) that are significantly associated with a decrease in BMD in women. We characterized a functional variant in exon 18 of SRC-1 that is associated with increased loss of bone mineral density in women who received tamoxifen for treatment or prevention of breast cancer. In vitro experiments show that this variant decreases estrogen receptor alpha response (ER-alpha) to hormone, suggesting an attenuated response to endogenous and exogenous hormones in the bone of these women, and therefore a need for additional bone protective measures.