Ryan O'neil Holcomb

US Patent:

6372742, Apr 16, 2002

Filed:

Jun 30, 2000

Appl. No.:

09/608861

Inventors:

Allison C. Chin - Stanford CA
Richard L. Tolman - Los Altos CA
Mark Q. Nguyen - San Jose CA
Ryan Holcomb - San Carlos CA

Assignee:

Geron Corporation - Menlo Park CA

International Classification:

A61K 314166

US Classification:

5142368, 51425402, 514369, 544133, 544367, 548183

Abstract:

5-(3-Isatinylidinyl)thiazolidineones and 3-(thiazolidinon-5-yl)indoles compounds, compositions, and methods of inhibiting telomerase activity in vitro and treatment of telomerase mediated conditions or diseases ex vivo and in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of conditions or diseases mediated by telomerase activity, such as in the treatment of cancer. Also disclosed are novel methods for assaying or screening for inhibitors of telomerase activity.

US Patent:

6452014, Sep 17, 2002

Filed:

Dec 22, 2000

Appl. No.:

09/748622

Inventors:

Tsutomu Akama - Redwood City CA
Ryan Holcomb - San Carlos CA
Richard L. Tolman - Los Altos CA

Assignee:

Geron Corporation - Menlo Park CA

International Classification:

A01N 4378

US Classification:

546260, 514394, 548182, 548186, 548189

Abstract:

Thiazolidinedione compounds, compositions, and methods of inhibiting telomerase activity in vitro and treatment of telomerase mediated conditions or diseases ex vivo and in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of conditions or diseases mediated by telomerase activity, such as in the treatment of cancer. Also disclosed are methods for assaying or screening for inhibitors of telomerase activity.

US Patent:

6518268, Feb 11, 2003

Filed:

Jun 30, 2000

Appl. No.:

09/608636

Inventors:

Allison C. Chin - Stanford CA
Ryan Holcomb - San Carlos CA
Mieczyslaw A. Piatyszek - Morgan Hill CA
Upinder Singh - Fremont CA
Richard L. Tolman - Los Altos CA
Tsutomu Akama - Redwood City CA
Yutaka Kanda - Tokyo, JP
Akira Asai - Sagamihara, JP
Yoshinori Yamashita - Tokyo, JP
Kaori Endo - Kamakura, JP
Hiroyuki Yamaguchi - Tokyo, JP

Assignee:

Geron Corporation - Menlo Park CA
Kyowa Hakko Kogyo Co., Ltd. - Tokyo

International Classification:

A61K 31535

US Classification:

5142368, 51425402, 514369, 514386, 544133, 544367, 548183

Abstract:

Thiazolidinedione compounds, compositions, and methods of inhibiting telomerase activity in vitro and treatment of telomerase mediated conditions or diseases ex vivo and in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of conditions or diseases mediated by telomerase activity, such as in the treatment of cancer. Also disclosed are novel methods for assaying or screening for inhibitors of telomerase activity.

US Patent:

20020115700, Aug 22, 2002

Filed:

Feb 13, 2002

Appl. No.:

10/077738

Inventors:

Allison Chin - Stanford CA, US
Richard Tolman - Los Altos CA, US
Mark Nguyen - San Jose CA, US
Ryan Holcomb - San Carlos CA, US

International Classification:

C07D417/02

US Classification:

514/369000, 548/183000

Abstract:

5-(3-Isatinylidinyl)thiazolidineones and 3-(thiazolidinon-5-yl)indoles compounds, compositions, and methods of inhibiting telomerase activity in vitro and treatment of telomerase mediated conditions or diseases ex vivo and in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of conditions or diseases mediated by telomerase activity, such as in the treatment of cancer. Also disclosed are novel methods for assaying or screening for inhibitors of telomerase activity.

US Patent:

20070032475, Feb 8, 2007

Filed:

Apr 6, 2006

Appl. No.:

11/398711

Inventors:

Xiaocong Ye - Palo Alto CA, US
Albert Garofalo - South San Francisco CA, US
Rose Lawler - San Francisco CA, US
Juri Fukuda - Oakland CA, US
Andrei Konradi - Burlingame CA, US
Ryan Holcomb - Bellevue WA, US
Kassandra Rossiter - San Jose CA, US
David Wone - Newark CA, US
Jing Wu - Redwood City CA, US

International Classification:

A61K 31/5513
A61K 31/55
A61K 31/4709
A61K 31/4545
A61K 31/454
C07D 217/22
C07D 211/68

US Classification:

514217120, 514221000, 514316000, 514318000, 540504000, 540605000, 546193000, 546142000, 514309000

Abstract:

Disclosed are compounds that are bradykinin Breceptor antagonists and are useful for treating diseases, or relieving adverse symptoms associated with disease conditions, in mammals mediated by bradykinin Breceptor.

US Patent:

6274738, Aug 14, 2001

Filed:

Nov 24, 1997

Appl. No.:

8/977651

Inventors:

Michael R. Kozlowski - Palo Alto CA
Junko Aimi - San Carlos CA
Ryan Holcomb - San Carlos CA

Assignee:

Geron Corporation - Menlo Park CA

International Classification:

C07D27760
A01N 3500

US Classification:

548148

Abstract:

The invention provides DNA primase assays suitable for identifying DN primase modulating agents, methods of modulating DNA primase activity, compounds for modulating DNA primase activity, and compositions which modulate DNA primase.