Ryan C Holcomb

US Patent:

6372742, Apr 16, 2002

Filed:

Jun 30, 2000

Appl. No.:

09/608861

Inventors:

Allison C. Chin - Stanford CA
Richard L. Tolman - Los Altos CA
Mark Q. Nguyen - San Jose CA
Ryan Holcomb - San Carlos CA

Assignee:

Geron Corporation - Menlo Park CA

International Classification:

A61K 314166

US Classification:

5142368, 51425402, 514369, 544133, 544367, 548183

Abstract:

5-(3-Isatinylidinyl)thiazolidineones and 3-(thiazolidinon-5-yl)indoles compounds, compositions, and methods of inhibiting telomerase activity in vitro and treatment of telomerase mediated conditions or diseases ex vivo and in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of conditions or diseases mediated by telomerase activity, such as in the treatment of cancer. Also disclosed are novel methods for assaying or screening for inhibitors of telomerase activity.

US Patent:

6452014, Sep 17, 2002

Filed:

Dec 22, 2000

Appl. No.:

09/748622

Inventors:

Tsutomu Akama - Redwood City CA
Ryan Holcomb - San Carlos CA
Richard L. Tolman - Los Altos CA

Assignee:

Geron Corporation - Menlo Park CA

International Classification:

A01N 4378

US Classification:

546260, 514394, 548182, 548186, 548189

Abstract:

Thiazolidinedione compounds, compositions, and methods of inhibiting telomerase activity in vitro and treatment of telomerase mediated conditions or diseases ex vivo and in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of conditions or diseases mediated by telomerase activity, such as in the treatment of cancer. Also disclosed are methods for assaying or screening for inhibitors of telomerase activity.

US Patent:

6518268, Feb 11, 2003

Filed:

Jun 30, 2000

Appl. No.:

09/608636

Inventors:

Allison C. Chin - Stanford CA
Ryan Holcomb - San Carlos CA
Mieczyslaw A. Piatyszek - Morgan Hill CA
Upinder Singh - Fremont CA
Richard L. Tolman - Los Altos CA
Tsutomu Akama - Redwood City CA
Yutaka Kanda - Tokyo, JP
Akira Asai - Sagamihara, JP
Yoshinori Yamashita - Tokyo, JP
Kaori Endo - Kamakura, JP
Hiroyuki Yamaguchi - Tokyo, JP

Assignee:

Geron Corporation - Menlo Park CA
Kyowa Hakko Kogyo Co., Ltd. - Tokyo

International Classification:

A61K 31535

US Classification:

5142368, 51425402, 514369, 514386, 544133, 544367, 548183

Abstract:

Thiazolidinedione compounds, compositions, and methods of inhibiting telomerase activity in vitro and treatment of telomerase mediated conditions or diseases ex vivo and in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of conditions or diseases mediated by telomerase activity, such as in the treatment of cancer. Also disclosed are novel methods for assaying or screening for inhibitors of telomerase activity.

US Patent:

7056937, Jun 6, 2006

Filed:

May 2, 2003

Appl. No.:

10/429203

Inventors:

Francine S. Grant - Mercer Island WA, US
Sarah Bartulis - Oakland CA, US
Louis Brogley - Santa Cruz CA, US
Michael S. Dappen - Redwood City CA, US
Ramesh Kasar - San Bruno CA, US
Ryan Holcomb - Bellevue WA, US
Michael A. Pleiss - Sunnyvale CA, US
Eugene D. Thorsett - Kirkland WA, US
Michael Ye - Palo Alto CA, US
Jon E. Hawkinson - Palo Alto CA, US

Assignee:

Elan Pharmaceuticals, Inc. - South San Francisco CA

International Classification:

A01N 43/40
A61K 31/44
C07D 239/00
C07D 239/70
C07D 47/00

US Classification:

514353, 514354, 544249

Abstract:

Disclosed are 1-sulfonylquioxalone acetamides and derivatives thereof. The compounds are exemplified by compounds of the formula:.

US Patent:

7074783, Jul 11, 2006

Filed:

Oct 9, 2003

Appl. No.:

10/685353

Inventors:

Ryan C. Holcomb - Bellevue WA, US
Francine S. Grant - Bellevue WA, US
Michael A. Pleiss - Sunnyvale CA, US
Eugene D. Thorsett - Half Moon Bay CA, US

Assignee:

Elan Pharmaceuticals, Inc. - South San Francisco CA

International Classification:

C07D 243/24
A61K 31/55

US Classification:

514221, 540512, 540513

Abstract:

Disclosed are compounds, which are bradykinin antagonists and are useful to treat diseases or relieve adverse symptoms associated with disease conditions in mammals mediated by bradykinin. Certain of the compounds exhibit increased potency and are expected to also exhibit an increased duration of action.

US Patent:

8093244, Jan 10, 2012

Filed:

Mar 29, 2006

Appl. No.:

11/908416

Inventors:

Frank Diaz - Florence AL, US
Francine S. Farouz - San Diego CA, US
Ryan Coatsworth Holcomb - Salt Lake City UT, US
Edward A. Kesicki - Bothell WA, US
Kimba Lee Fischer - Longmont CO, US
Adam Wade Cook - Broomfield CO, US

Assignee:

ICOS Corporation - Indianapolis IN

International Classification:

A61P 35/00
A61K 31/497
A61K 31/5355
A61K 31/541
C07D 403/12
C07D 413/12
C07D 417/12

US Classification:

5142358, 544120

Abstract:

Substituted urea compounds useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating cancer and other diseases characterized by defects in DNA replication, chromosome segregation, or cell division, also are disclosed.

US Patent:

8314108, Nov 20, 2012

Filed:

Dec 10, 2009

Appl. No.:

12/634725

Inventors:

Francine S. Farouz - LaJolla CA, US
Ryan Coatsworth Holcomb - Salt Lake City UT, US
Ramesh Kasar - San Mateo CA, US
Steven Scott Myers - Sheridan IN, US

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

A61K 31/4965

US Classification:

51425506, 544336, 5483771

Abstract:

The present invention provides an aminopyrazole compound, more particularly,.

US Patent:

20020115700, Aug 22, 2002

Filed:

Feb 13, 2002

Appl. No.:

10/077738

Inventors:

Allison Chin - Stanford CA, US
Richard Tolman - Los Altos CA, US
Mark Nguyen - San Jose CA, US
Ryan Holcomb - San Carlos CA, US

International Classification:

C07D417/02

US Classification:

514/369000, 548/183000

Abstract:

5-(3-Isatinylidinyl)thiazolidineones and 3-(thiazolidinon-5-yl)indoles compounds, compositions, and methods of inhibiting telomerase activity in vitro and treatment of telomerase mediated conditions or diseases ex vivo and in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of conditions or diseases mediated by telomerase activity, such as in the treatment of cancer. Also disclosed are novel methods for assaying or screening for inhibitors of telomerase activity.