Alain Delcayre - San Jose CA, US Reiner Laus - Saratoga CA, US Stefanie Mandl - San Francisco CA, US Ryan Blair Rountree - San Jose CA, US Fatema Legrand - San Carlos CA, US
Assignee:
BN ImmunoTherapeutics, Inc. - Mountain View CA
International Classification:
A61K 350/00 C12N 15/63
US Classification:
4353201, 424 931
Abstract:
The invention relates to compositions, kits, and methods for cancer prophylaxis and therapy using recombinant MVA viruses encoding tumor-associated antigens, such as PSA and PAP. The recombinant MVA viruses can induce B-and T-cell responses. The recombinant MVA viruses can be administered prior to, at the same time as, or after a taxane.
Alain Delcayre - San Jose CA, US Reiner Laus - Saratoga CA, US Stefanie Mandl - San Francisco CA, US Ryan Blair Rountree - San Jose CA, US Fatema Legrand - San Carlos CA, US
International Classification:
A61K 39/145 C12N 7/01 A61P 35/00
US Classification:
4241991, 4352351
Abstract:
The invention relates to compositions, kits, and methods for cancer prophylaxis and therapy using recombinant MVA viruses encoding tumor-associated antigens, such as PSA and PAP. The recombinant MVA viruses can induce B- and T-cell responses. The recombinant MVA viruses can be administered prior to, at the same time as, or after a taxane.
Compositions And Methods For Enhancing The Stability Of Transgenes In Poxviruses
- Hellerup, DK Ryan Rountree - San Mateo CA, US Ulrike Dirmeier - Starnberg, DE
Assignee:
Bavarian Nordic A/S - Hellerup
International Classification:
A61K 39/00 C07K 14/47 C07K 14/705 C12N 15/863
Abstract:
Provided herein are recombinant poxviruses that are stable through successive passaging of the recombinant poxviruses. More particularly, the recombinant poxviruses comprise one or more modified nucleic acids encoding MUC1, CEA, and/or TRICOM antigens, wherein the recombinant poxviruses are stable through successive passaging. Also, provided herein are compositions and method related thereto.
Combination Therapy For Treating Cancer With A Poxvirus Expressing A Tumor Antigen And An Antagonist Of An Immune Checkpoint Inhibitor
- Hellerup, DK Stefanie Mandl - San Francisco CA, US Ryan Rountree - San Jose CA, US Alain Delcayre - San Jose CA, US
Assignee:
Bavarian Nordic A/S - Hellerup
International Classification:
A61K 39/00 A61K 39/395 C12N 7/00
Abstract:
The present disclosure encompasses therapies, compositions, and methods for treatment of a human cancer patient using a recombinant poxvirus encoding a tumor-associated antigen in combination with one or more agonists or antagonists of immune checkpoint inhibitors.
Compositions And Methods For Enhancing The Stability Of Transgenes In Poxviruses
- Kvistgaard, DK Ryan Rountree - San Mateo CA, US Ulrike Dirmeier - Starnberg, DE
Assignee:
Bavarian Nordic A/S - Kvistgaard
International Classification:
A61K 39/00 C07K 14/47 C07K 14/705 C12N 15/863
Abstract:
Provided herein are recombinant poxviruses that are stable through successive passaging of the recombinant poxviruses. More particularly, the recombinant poxviruses comprise one or more modified nucleic acids encoding MUC1, CEA, and/or TRICOM antigens, wherein the recombinant poxviruses are stable through successive passaging. Also, provided herein are compositions and method related thereto.
- Kvistgaard, DK Alain Delcayre - San Jose CA, US Ryan Rountree - San Mateo CA, US
Assignee:
Bavarian Nordic A/S - Kvistgaard
International Classification:
C12N 15/86 C07K 14/435
Abstract:
The present invention relates to one or more promoters and/or expression cassettes that can be used for enhancing expression of a heterologous gene, such as Brachury. In particular, the one or more promoters and/or expression cassettes enhance expression of heterologous genes as part of a viral vector, such as a poxvirus.
Combination Therapy For Treating Cancer With A Poxvirus Expressing A Tumor Antigen And An Antagonist And/Or Agonist Of An Immune Checkpoint Inhibitor
The invention relates to compositions, kits, and methods for cancer therapy using recombinant poxviruses encoding a tumor-associated antigen in combination with antagonists or agonists of immune checkpoint inhibitors.
Combination Therapy For Treating Cancer With A Poxvirus Expressing A Tumor Antigen And An Antagonist Of Tim-3
- Kvistgaard, DK STEFANIE MANDL - San Francisco CA, US RYAN ROUNTREE - San Jose CA, US
Assignee:
Bavarian Nordic A/S - Kvistgaard
International Classification:
A61K 39/00 C12N 7/00 C07K 16/28 A61K 39/395
Abstract:
The invention relates to compositions, kits, and methods for cancer therapy using recombinant poxviruses encoding a tumor-associated antigen in combination with a monoclonal antibody against immune checkpoint molecule TIM-3.
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