Sameer Tyagi from Cary, NC, age 55

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Author
Sameer Tyagi

ISBN #
0131407317

Aryl And Heteroaryl Compounds, Compositions, And Methods Of Use
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US Patent:

7208601, Apr 24, 2007
Filed:

Mar 1, 2005
Appl. No.:

11/069521
Inventors:

Adnan M. M. Mjalli - Jamestown NC, US
Sameer Tyagi - High Point NC, US
International Classification:

C07D 217/00
US Classification:

546146
Abstract:

This invention provides aryl and heteroaryl compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of the invention may be useful as antagonists, or partial antagonist of factor IX and/or factor XI and thus, may be used to inhibit the intrinsic pathway of blood coagulation. The compounds may be useful in a variety of applications including the management, treatment and/or control of diseases caused in part by the intrinsic clotting pathway utilizing factor IX and/or XI.

Aryl And Heteroaryl Compounds, Compositions, And Methods Of Use
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US Patent:

7544699, Jun 9, 2009
Filed:

Aug 6, 2004
Appl. No.:

10/913168
Inventors:

Adnan M. M. Mjalli - Jamestown NC, US
Robert C. Andrews - Jamestown NC, US
Xiao-Chuan Guo - High Point NC, US
Daniel Peter Christen - Jamestown NC, US
Guoxiang Huang - Greensboro NC, US
Robert Rothlein - Summerfield NC, US
Sameer Tyagi - High Point NC, US
Tripura Yaramasu - Greensboro NC, US
Christopher Behme - Jamestown NC, US
Assignee:

Transtech Pharma, Inc. - High Point NC
International Classification:

C07D 217/00
A61K 31/47
US Classification:

514309, 546146
Abstract:

This invention provides aryl and heteroaryl compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of the invention may be antagonists, or partial antagonist of factor IX and/or factor XI and thus, may be useful for inhibiting the intrinsic pathway of blood coagulation. The compounds may be useful in a variety of applications including the management, treatment and/or control of diseases caused in part by the intrinsic clotting pathway.

Aryl And Heteroaryl Compounds And Methods To Modulate Coagulation
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US Patent:

20040110832, Jun 10, 2004
Filed:

Aug 8, 2003
Appl. No.:

10/637900
Inventors:

Adnan Mjalli - Jamestown NC, US
Robert Andrews - Jamestown NC, US
Xiao-Chuan Guo - High Point NC, US
Daniel Christen - High Point NC, US
Guoxiang Huang - Greensboro NC, US
Robert Rothlein - Summerfield NC, US
Sameer Tyagi - High Point NC, US
Tripura Yaramasu - Greensboro NC, US
Christopher Behme - Jamestown NC, US
International Classification:

A61K031/325
A61K031/18
A61K031/17
A61K031/165
US Classification:

514/485000, 514/597000, 514/603000, 514/607000, 514/626000, 560/024000, 564/050000, 564/079000, 564/089000
Abstract:

This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of the invention are useful as antagonists, or more preferably, partial antagonist of factor IX and thus, may be used to inhibit the intrinsic pathway of blood coagulation. The compounds are useful in a variety of applications including the management, treatment and/or control of diseases caused in part by the intrinsic clotting pathway utilizing factor IX. Such diseases or disease states include stroke, myocardial infarction, aneurysm surgery, and deep vein thrombosis associated with surgical procedures, long periods of confinement, and acquired or inherited pro-coagulant states.

Aryl And Heteroaryl Compounds And Methods To Modulate Coagulation
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US Patent:

20060276518, Dec 7, 2006
Filed:

Aug 7, 2006
Appl. No.:

11/500225
Inventors:

Adnan Mjalli - Jamestown NC, US
Robert Andrews - Jamestown NC, US
Xiao-Chuan Guo - High Point NC, US
Daniel Christen - High Point NC, US
Guoxiang Huang - Greensboro NC, US
Robert Rothlein - Summerfield NC, US
Sameer Tyagi - High Point NC, US
Tripura Yaramasu - Greensboro NC, US
Christopher Behme - Jamestown NC, US
International Classification:

A61K 31/44
A61K 31/40
A61K 31/18
A61K 31/16
A61K 31/175
US Classification:

514357000, 514408000, 514602000, 514592000, 514616000
Abstract:

This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of the invention are useful as antagonists, or more preferably, partial antagonist of factor IX and thus, may be used to inhibit the intrinsic pathway of blood coagulation. The compounds are useful in a variety of applications including the management, treatment and/or control of diseases caused in part by the intrinsic clotting pathway utilizing factor IX. Such diseases or disease states include stroke, myocardial infarction, aneurysm surgery, and deep vein thrombosis associated with surgical procedures, long periods of confinement, and acquired or inherited pro-coagulant states.

Aryl And Heteroaryl Compounds, Compositions, And Methods Of Use
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US Patent:

20070254916, Nov 1, 2007
Filed:

Mar 5, 2007
Appl. No.:

11/714031
Inventors:

Adnan Mjalli - Oak Ridge NC, US
Sameer Tyagi - High Point NC, US
International Classification:

A61K 31/47
A61P 9/00
US Classification:

514311000, 514314000
Abstract:

This invention provides aryl and heteroaryl compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of the invention may be useful as antagonists, or partial antagonist of factor IX and/or factor XI and thus, may be used to inhibit the intrinsic pathway of blood coagulation. The compounds may be useful in a variety of applications including the management, treatment and/or control of diseases caused in part by the intrinsic clotting pathway utilizing factor IX and/or XI.

Aryl And Heteroaryl Compounds, Compositions, Methods Of Use
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US Patent:

20090124654, May 14, 2009
Filed:

Feb 23, 2006
Appl. No.:

11/884595
Inventors:

Adnan M.M. Mjalli - Oak Ridge NC, US
Sameer Tyagi - High Point NC, US
International Classification:

A61K 31/4725
C07D 409/12
A61P 9/10
US Classification:

514307, 546147
Abstract:

This invention provides aryl and heteroaryl compounds of formula (X). The compounds of the invention may be useful as antagonists, or partial antagonist of factor IX and/or factor XI and thus, may be used to inhibit the intrinsic pathway of blood coagulation. Formula (X) wherein Ris selected from the group consisting of —C(O)OH, —C(O)OCH, —C(O)O-t-butyl, —C(O)NH—OCH-phenyl, C(O)NHOH, and —C(O)NHSOCH; and wherein R, R, Rand Y are as defined herein.