Samson C Chan

US Patent:

20070110751, May 17, 2007

Filed:

Oct 25, 2006

Appl. No.:

11/586326

Inventors:

Robb MacLellan - Sherman Oaks CA, US
Peipei Ping - Marina del Rey CA, US
David Liem - Los Angeles CA, US
Samson Chan - Alhambra CA, US

International Classification:

A61K 39/395
A61K 31/55
A61K 31/522
A61K 31/353
A61K 31/513

US Classification:

424146100, 424718000, 514044000, 514211090, 514215000, 514263320, 514269000, 514456000

Abstract:

Disclosed are compositions and methods for Disclosed are methods related to the use of Cdk2 inhibitors to reducing myocardial ischemic/reperfusion injury including but not limited to reduced infarct size. It is also disclosed that the same methods are equally appropriate for use in reducing injury following stroke including but not limited to (ischemic strokes (including strokes resulting from cerebral thrombosis, cerebral embolism, and atrial fibrillation), hemorrhagic strokes (including strokes resulting from aneurysm and arteriovenous malformation), and transient ischemic attack), reducing infarct size following pulmonary infarction, reducing renal ischemia injury, reducing ischemic/reperfusion injury occurring during cardiac surgery where a heart lung machine is used such as Coronary artery bypassing, and reducing ischemic/reperfusion injury occurring during the preservation of organs for transplant.