Samuel S Chan

US Patent:

7540615, Jun 2, 2009

Filed:

Aug 15, 2008

Appl. No.:

12/192245

Inventors:

Michael M. Merzenich - San Francisco CA, US
Dylan Bird - San Francisco CA, US
Donald F. Brenner - San Francisco CA, US
Samuel C. Chan - Alameda CA, US
Peter B. Delahunt - San Mateo CA, US
Joseph L. Hardy - Richmond CA, US
Stephen G. Lisberger - San Francisco CA, US
Henry W. Mahncke - San Francisco CA, US

Assignee:

Posit Science Corporation - San Francisco CA

International Classification:

A61B 3/00
A61B 3/02

US Classification:

351246, 351203, 351238, 351239

Abstract:

Computer-implemented method for enhancing a participant's cognition, including, e. g. , visual memory, utilizing a computing device to present visual stimuli for training, and to record responses from the participant. Multiple graphical elements are provided for visual presentation to the participant. A temporal sequence of a plurality of the graphical elements is visually presented, including displaying each graphical element in the sequence at a respective location in a visual field for a specified duration, then ceasing to display the graphical element. The presented graphical elements include at least two matching graphical elements. The participant is required to respond to the presented sequence, including indicating locations of matching graphical elements. A determination is made as to whether the participant responded correctly, and the duration modified based on the determining. The visually presenting, requiring, determining, and modifying are repeated one or more times in an iterative manner to improve the participant's cognition.

US Patent:

20010051338, Dec 13, 2001

Filed:

Jan 31, 2001

Appl. No.:

09/774531

Inventors:

Samuel Chan - Daly City CA, US
Andrea Chow - Los Altos CA, US
Benjamin Wang - Palo Alto CA, US

International Classification:

C12Q001/68
G01N033/53
C12Q001/34

US Classification:

435/006000, 435/007100, 435/018000

Abstract:

Methods for monitoring time dependent reactions that comprise providing a flow channel, typically microscale in dimension, flowing at least two reagents into the flow channel and varying the flow rate of the mixture through the flow channel. By increasing and/or decreasing the flow rate of the reagent mixture from the point of mixing to the point of detection, one alters the amount of reaction time, allowing monitoring reaction kinetics over time.

US Patent:

20030203353, Oct 30, 2003

Filed:

May 20, 2003

Appl. No.:

10/442006

Inventors:

Samuel Chan - Daly City CA, US
Andrea Chow - Los Altos CA, US
Benjamin Wang - Cambridge MA, US

Assignee:

Caliper Technologies Corp. - Mountain View CA

International Classification:

C12Q001/00
C12Q001/68
G01N033/53

US Classification:

435/004000, 435/006000, 435/007100

Abstract:

Methods for monitoring time dependent reactions that comprise providing a flow channel, typically microscale in dimension, flowing at least two reagents into the flow channel and varying the flow rate of the mixture through the flow channel. By increasing and/or decreasing the flow rate of the reagent mixture from the point of mixing to the point of detection, one alters the amount of reaction time, allowing monitoring reaction kinetics over time.

US Patent:

20070134632, Jun 14, 2007

Filed:

Aug 17, 2006

Appl. No.:

11/465313

Inventors:

Samuel Chan - Alameda CA, US
Joseph Hardy - El Cerrito CA, US
Henry Mahncke - San Francisco CA, US

Assignee:

Posit Science Corporation - San Francisco CA

International Classification:

G09B 19/00

US Classification:

434236000

Abstract:

A computer-implemented method is described for assessing an aging adult's ability to integrate visual-spatial and auditory memory by requiring the adult to spatially match pairs of graphically presented response buttons that are associated with aurally presented stimuli which is processed by a computing device. The adult is presented with a grid of response buttons, each associated with an aural stimulus. When the adult selects a response button, its aural stimulus is presented. The adult is required to consecutively select a response button having the same aural stimulus. As the adult sequentially selects response buttons having the same aural stimuli, the button pair is removed. First assessment trials are performed for a first plurality of grids, training trials are performed for a second plurality of grids, then second assessment trials performed for the first plurality of grids. The adult's performances in the two assessments are compared to determine the adult's improvement.

US Patent:

20070134633, Jun 14, 2007

Filed:

Aug 17, 2006

Appl. No.:

11/465322

Inventors:

Samuel Chan - Alameda CA, US
Joseph Hardy - El Cerrito CA, US
Henry Mahncke - San Francisco CA, US

Assignee:

Posit Science Corporation - San Francisco CA

International Classification:

G09B 19/00

US Classification:

434236000

Abstract:

A method on a computing device for determining a psychophysical threshold regarding an aging adult's ability to temporarily store and retrieve an order of the syllables by requiring the adult to listen to two or more aurally processed syllables, presented serially, view the syllables graphically, and designate the order in which the syllables were presented. Two tracks are initialized to respective stage values, each corresponding to attributes of the presented syllables. A number of trials are performed according to each of the two tracks. As the adult attempts to determine the syllable order in trials, correct/incorrect selection of an order causes the stage value of a track to be adaptively reduced/increased, using a maximum likelihood procedure, e.g., ZEST, where the two tracks are adjusted until their values substantially converge, or a specified number of trials is performed. The final stage values of the tracks are averaged to determine the threshold.

US Patent:

20070134634, Jun 14, 2007

Filed:

Aug 17, 2006

Appl. No.:

11/465333

Inventors:

Samuel Chan - Alameda CA, US
Joseph Hardy - El Cerrito CA, US
Henry Mahncke - San Francisco CA, US

Assignee:

Posit Science Corporation - San Francisco CA

International Classification:

G09B 19/00

US Classification:

434236000

Abstract:

Computer-implemented method for determining a threshold regarding an aging adult's ability to remember and perform sequences of auditory instructions. A stage specifies a set of stimulus attributes. First and second tracks are respectively initialized to stage values below and above an initial anticipated threshold specifying an initial estimate of stimulus attributes corresponding to a specified performance level of the adult. A sequence of auditory instructions is presented indicating respective manipulations of graphical objects in accordance with the stage value of a specified one of either the first or second track. Input manipulating the graphical objects is received from the adult, and the stage value of the track modified in response. This is performed with respect to each of a plurality of sequences to determine final stage values for the tracks, and a threshold comprising the stage value associated with the specified performance level determined based on the final stage values.

US Patent:

20070141541, Jun 21, 2007

Filed:

Aug 17, 2006

Appl. No.:

11/465290

Inventors:

Samuel Chan - Alameda CA, US
Joseph Hardy - El Cerrito CA, US
Henry Mahncke - San Francisco CA, US

Assignee:

Posit Science Corporation - San Francisco CA

International Classification:

G09B 19/00

US Classification:

434236000

Abstract:

A method on a computing device is provided for assessing a stimulus threshold of an older adult by requiring the adult to differentiate between rapidly presented stimuli. The method trains the time order judgment of the adult by presenting upward and downward frequency sweeps, in random order, separated by an inter-stimulus interval (ISI). Icons associated with the upward and downward frequency sweeps allow the adult to indicate an order in which the frequency sweeps are presented (i.e., UP-UP, UP-DOWN, DOWN-UP, and DOWN-DOWN). Correct/incorrect selection of an order causes the inter-stimulus interval and/or the duration of the frequency sweeps to be adaptively reduced/increased, using a maximum likelihood procedure, such as ZEST or QUEST, where two tracks, each with a respective duration and ISI, are adjusted until their values substantially converge, or a specified number of trials is performed. The threshold is determined by averaging the final values of the two tracks.

US Patent:

20070166675, Jul 19, 2007

Filed:

Dec 15, 2006

Appl. No.:

11/611291

Inventors:

Sharona Atkins - Oakland CA, US
Dylan Bird - San Francisco CA, US
Samuel Chan - Alameda CA, US
Peter Delahunt - San Mateo CA, US
Shruti Gangadhar - San Francisco CA, US
Joseph Hardy - Richmond CA, US
Stephen Lisberger - San Francisco CA, US
Henry Mahncke - San Francisco CA, US
Michael Merzenich - San Francisco CA, US
Donald Richards - Lagunitas CA, US

Assignee:

POSIT SCIENCE CORPORATION - San Francisco CA

International Classification:

G09B 19/00

US Classification:

434236000

Abstract:

A computer-implemented method for enhancing cognition, e.g., for improving cognitive ability of a participant using visual stimuli. A set (or sets) of visual stimuli is provided for visual presentation to the participant. A visual stimulus from the set is visually presented to the participant. The participant is required to respond to the visual stimulus. A determination is made regarding whether the participant responded correctly. The stimulus intensity of the visual stimuli presented may be adjusted based on the correctness/incorrectness of the participant's response according to a single-stair maximum likelihood (e.g., ZEST) or N-up/M-down procedure. The visually presenting, requiring, and determining are repeated one or more times in an iterative manner to improve the participant's cognition, e.g., ability to process visual information, memory, etc. Assessments may be performed during the repeating according to a dual-stair maximum likelihood (e.g., ZEST) or N-up/M-down procedure. The repeating may include performing multiple exercises using visual stimuli.