A restrainer system for performing awake-animal imaging on a rodent. The system comprises a front section, a first pair of adjustable side pieces for contacting with a snout of the rodent from both sides, a second pair of adjustable side pieces for contacting with a rear jaw of the rodent from both sides, a front section, first floating component for applying pressure to a nose section of the rodent during testing and a mouthpiece for holding the rodent's teeth. That front section connects to a middle section having a floor element upon which to rest a main body of the rodent and all four limbs, a pair of adjustable walls for applying pressure to the rodent's back legs, and a middle section floating component for applying pressure to the rodent's shoulder blades from above. The latter connects to a rear section having a plateau onto which to rest the rodent's tail, and a rear section floating component for securing over the rodent's tail. A method of use is also disclosed.
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