Samuel W Inman

US Patent:

8318479, Nov 27, 2012

Filed:

May 19, 2005

Appl. No.:

11/133092

Inventors:

Karel Domansky - Cambridge MA, US
Linda G. Griffith - Cambridge MA, US
Steven R. Tannenbaum - Framingham MA, US
Alan Wells - Pittsburgh PA, US
Samuel Walker Inman - Boston MA, US

Assignee:

Massachusetts Institute of Technology - Cambridge MA
Univeristy of Pittsburgh—Of the Commonwealth System of Higher Education - Pittsburgh PA

International Classification:

C12M 1/22
C12M 3/00
C12M 1/34

US Classification:

4353052, 4353841, 4352873, 4352882, 4352883, 4352885, 4352931, 4353051, 4352991, 4353071

Abstract:

A system has been constructed that recapitulate the features of a capillary bed through normal human tissue. The system facilitates perfusion of three-dimensional (3D) cell monocultures and heterotypic cell co-cultures at the length scale of the capillary bed. A major feature is that the system can be utilized within a “multiwell plate” format amenable to high-throughput assays compatible with the type of robotics commonly used in pharmaceutical development. The system provides a means to conduct assays for toxicology and metabolism and as a model for human diseases such as hepatic diseases, including hepatitis, exposure-related pathologies, and cancer. Cancer applications include primary liver cancer as well as metastases. The system can also be used as a means of testing gene therapy approaches for treating disease and inborn genetic defects.

US Patent:

20140030752, Jan 30, 2014

Filed:

Jul 25, 2013

Appl. No.:

13/951067

Inventors:

Anilkumar Harapanahalli Achyuta - Tampa FL, US
Mark J. Mescher - West Newton MA, US
Linda Griffith - Cambridge MA, US
Samuel Walker Inman - Boston MA, US

International Classification:

C12M 3/00
G01N 33/50

US Classification:

435 29, 4352891, 4352885, 435325, 435375

Abstract:

The systems and methods disclosed herein are generally related to a cell culture system. More particularly, the systems and methods enable the culturing and interconnecting of a plurality of tissue types in a biomimetic environment. By culturing organ specific tissue types within a biomimetic environment and interconnecting each of the organ systems in a physiologically meaningful way, experiments can be conducted on in vitro cells that substantially mimic the responses of in vivo cell populations. In some implementations, the system is used to monitor how organ systems respond to agents such as toxins or medications. The system enables the precise and controlled delivery of these agents, which, in some implementations, enables the biomimetic dosing of drugs in humans to be mimicked.

US Patent:

20170137768, May 18, 2017

Filed:

Nov 23, 2016

Appl. No.:

15/360457

Inventors:

- Cambridge MA, US
Anilkumar Harapanahalli Achyuta - Tampa FL, US
Mark J. Mescher - West Newton MA, US
Linda Griffith - Cambridge MA, US
Samuel Walker Inman - Boston MA, US

International Classification:

C12M 3/00
C12M 1/34
C12M 1/00

Abstract:

The systems and methods disclosed herein are generally related to a cell culture system. More particularly, the systems and methods enable the culturing and interconnecting of a plurality of tissue types in a biomimetic environment. By culturing organ specific tissue types within a biomimetic environment and interconnecting each of the organ systems in a physiologically meaningful way, experiments can be conducted on in vitro cells that substantially mimic the responses of in vivo cell populations. In some implementations, the system is used to monitor how organ systems respond to agents such as toxins or medications. The system enables the precise and controlled delivery of these agents, which, in some implementations, enables the biomimetic dosing of drugs in humans to be mimicked.

US Patent:

20160145553, May 26, 2016

Filed:

Feb 1, 2016

Appl. No.:

15/012577

Inventors:

- Cambridge MA, US
Jonathan Robert Coppeta - Windham NH, US
Samuel Walker Inman - Boston MA, US
Abigail June Spencer - Boston MA, US
Transon Van Nguyen - San Diego CA, US
Jeffrey T. Borenstein - Newton MA, US

International Classification:

C12M 3/00
C12M 1/34
C12M 1/00
C12N 5/071
C12N 5/00

Abstract:

The systems and methods disclosed herein are generally related to a cell culture system. More particularly, the systems and methods enable the culturing and interconnecting of a plurality of tissue types in a biomimetic environment. By culturing organ specific tissue types within a biomimetic environment and interconnecting each of the organ systems in a physiologically meaningful way, experiments can be conducted on in vitro cells that substantially mimic the responses of in vivo cell populations. In some implementations, the organ systems are fluidically connected with a constant-volume pump.

US Patent:

20140212964, Jul 31, 2014

Filed:

Jan 29, 2014

Appl. No.:

14/167590

Inventors:

- Cambridge MA, US
Jonathan Robert Coppeta - Windham NH, US
Samuel Walker Inman - Boston MA, US
Abigail June Spencer - Boston MA, US
Transon Van Nguyen - San Diego CA, US
Jeffrey T. Borenstein - Newton MA, US

Assignee:

The Massachusetts Institute of Technology - Cambridge MA
The Charles Stark Draper Laboratory, Inc. - Cambridge MA

International Classification:

C12N 5/071

US Classification:

435325, 4353051

Abstract:

The systems and methods disclosed herein are generally related to a cell culture system. More particularly, the systems and methods enable the culturing and interconnecting of a plurality of tissue types in a biomimetic environment. By culturing organ specific tissue types within a biomimetic environment and interconnecting each of the organ systems in a physiologically meaningful way, experiments can be conducted on in vitro cells that substantially mimic the responses of in vivo cell populations. In some implementations, the organ systems are fluidically connected with a constant-volume pump.

US Patent:

20140084181, Mar 27, 2014

Filed:

May 18, 2012

Appl. No.:

14/118303

Inventors:

Samuel Walker Inman - Boston MA, US
Ian W. Hunter - Lincoln MA, US

International Classification:

G01N 21/64

US Classification:

2504591, 2504581, 250216

Abstract:

A material is excited with light whose intensity is modulated according to a modulation signal. The modulation signal includes multiple transitions between at least two intensity levels, with times of at least a first contiguous sequence of the transitions being selected according to an irregular pattern. A response of the material to the excitation is detected.