Sandra A Gonzalez

US Patent:

20070213553, Sep 13, 2007

Filed:

Mar 10, 2006

Appl. No.:

11/372959

Inventors:

Hongbo Liu - Hillsborough NJ, US
Sandra Gonzalez - Hillsborough NJ, US

International Classification:

C07C 253/30

US Classification:

558441000

Abstract:

A method for producing a cyanoacrylate monomer, comprising the steps of (a) reacting cyanoacetate and formaldehyde or paraformaldehyde in the presence of a base or amine base catalyst to form an α-cyanoacrylate prepolymer or oligomer mixture; (b) subjecting the α-cyanoacrylate prepolymer or oligomer mixture to a substrate having free acid, acid derivative, or free aldehyde or ketone groups to remove the catalyst and to obtain a purified α-cyanoacrylate prepolymer or oligomer; and (c) subjecting the purified α-cyanoacrylate prepolymer or oligomer to depolymerization to obtain an α-cyanoacrylate monomer.

US Patent:

20110230561, Sep 22, 2011

Filed:

Nov 17, 2009

Appl. No.:

13/130591

Inventors:

Hongbo Liu - Hillsborough NJ, US
Sandra Gonzalez - Bedminster NJ, US
Breda Mary Cullen - North Yorkshire, GB
Derek Walter Silcock - North Yorkshire, GB

International Classification:

A61K 47/16
A61K 31/192
A61K 31/16
C08F 120/44
A61P 29/00

US Classification:

514570, 514785, 514630, 526328

Abstract:

A medical adhesive composition comprising, based upon the total weight of the composition, from about 50 wt. % to about 99.9 wt. % of one or more α-cyanoacrylate monomers and from about 0.1 wt. % to about 5 wt. % of one or more non-steroidal anti-inflammatory drugs (NSAIDs). Suitable NSAIDs include ibuprofen and acetaminophen. The resulting compositions provide enhances fibroblast proliferation and reduced cytotoxicity compared to compositions that do not contain NSAID.