Sandra M O'Connor

US Patent:

20120270772, Oct 25, 2012

Filed:

Nov 23, 2010

Appl. No.:

13/511246

Inventors:

Sandra O'Connor - Hudson NH, US
Sophie Sun - Lexington MA, US
Gaauri Naik - Cambridge MA, US

Assignee:

CUBIST PHARMACEUTICALS, INC. - Lexington MA

International Classification:

A61K 38/12
A61P 31/00

US Classification:

514 23

Abstract:

The present disclosure provides novel powder daptomycin formulations which have improved chemical stability and faster reconstitution times when in the solid state. Some examples of the compositions comprise daptomycin and sucrose.

US Patent:

20130109633, May 2, 2013

Filed:

May 25, 2012

Appl. No.:

13/481009

Inventors:

Sandra O'Connor - Hudson NH, US
Sophie Sun - Lexington MA, US
Gaauri Naik - Cambridge MA, US

Assignee:

Cubist Pharmaceuticals, Inc. - Lexington MA

International Classification:

A61K 38/12

US Classification:

514 211

Abstract:

The present disclosure provides novel solid CB-183,315 formulations which have improved chemical stability. The chemical stability of the solid CB-183,315 is dependent on the process by which the composition is made. Solid preparations of CB-183,315 can be prepared by the following method: (a) forming an aqueous solution of CB-183,315 and at least one sugar that (e.g., sucrose, trehalose or dextran) at a pH of 2-7, preferably pH 6 and (b) converting the aqueous solution to the solid preparation of CB-183,315 (e.g., via lyophilization or spray drying).

US Patent:

20140135273, May 15, 2014

Filed:

Oct 7, 2013

Appl. No.:

14/047701

Inventors:

Sandra O'CONNOR - Hudson NH, US
Sophie Sun - Lexington MA, US
Gaauri Naik - Cambridge MA, US

Assignee:

Cubist Pharmaceuticals, Inc. - Lexington MA

International Classification:

A61K 38/12

US Classification:

514 211

Abstract:

The present disclosure provides novel solid CB-183,315 formulations which have improved chemical stability. The chemical stability of the solid CB-183,315 is dependent on the process by which the composition is made. Solid preparations of CB-183,315 can be prepared by the following method: (a) forming an aqueous solution of CB-183,315 and at least one sugar that (e.g., sucrose, trehalose or dextran) at a pH of 2-7, preferably pH 6 and (b) converting the aqueous solution to the solid preparation of CB-183,315 (e.g., via lyophilization or spray drying).