Sandra Kt Pearce

US Patent:

20090104712, Apr 23, 2009

Filed:

Sep 11, 2008

Appl. No.:

12/209093

Inventors:

Paul F. Coleman - Antioch IL, US
Sandra K. Pearce - Evanston IL, US

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

G01N 33/566
C12N 15/11
C12N 15/00
C12N 5/06
C07K 14/00

US Classification:

436501, 536 2372, 4353201, 435325, 530350

Abstract:

This invention relates to a nucleic acid molecule encoding a middle Hepatitis B virus (HBV) surface protein, a vector comprising the nucleic acid molecule, a host cell comprising the vector, and a composition comprising the expression products of this vector, which may comprise middle HBV surface protein, or a mixture of middle HBV surface protein and small HBV surface protein. The compositions of the invention may be useful for expressing a middle HBV surface protein, or a mixture of small and middle HBV surface proteins in defined ratios, determining the binding of an antibody to a middle or small HBV surface protein, determining the quality of an anti-middle or an anti-small HBV surface protein antibody, or determining the quality of a kit containing anti-middle or anti-small HBV surface protein antibodies.