Sang Mun Lim

US Patent:

8140269, Mar 20, 2012

Filed:

Mar 12, 2008

Appl. No.:

12/046988

Inventors:

Bhubaneswar Mishra - Great Neck NY, US
Thomas Anantharaman - DeForest WI, US
Sang Lim - Tarrytown NY, US

Assignee:

New York University - New York NY

International Classification:

G01N 33/48
C12Q 1/68
G06G 7/58

US Classification:

702 19, 435 6, 702 20, 703 11

Abstract:

Methods, computer-accessible medium, and systems for generating a genome wide probe map and/or a genome wide haplotype sequence are provided. In particular, a genome wide probe map can be generated by obtaining a plurality of detectable oligonucleotide probes hybridized to at least one double stranded nucleic acid molecule cleaved with at least one restriction enzyme, and detecting the location of the detectable oligonucleotide probes. For example, genome wide haplotype sequence can be generated by analyzing at least one genome wide restriction map in conjunction with at least one genome wide probe map to determine distances between restriction sites of the at least one genome wide restriction map and locations of detectable oligonucleotide probes of the at least one genome wide probe map and defining a consensus map indicating restriction sites based on each of the at least one genome wide restriction map and locations of detectable oligonucleotide probes based on each of the at least one genome wide probe map.