Santosh K Patnaik

US Patent:

20180072793, Mar 15, 2018

Filed:

Apr 11, 2016

Appl. No.:

15/564984

Inventors:

- Buffalo NY, US
Shraddha SHARMA - Williamsville NY, US
Santosh K. PATNAIK - Buffalo NY, US

International Classification:

C07K 14/775
C12Q 1/68
C07K 14/57
C12N 15/11
C12N 9/78

Abstract:

Provided are methods for identifying agents which can induce or inhibit C>U deamination in RNA driven by apolipoprotein B editing catalytic proteins. The method comprises contacting APOBEC3A or APOBEC3G with a suitable RNA substrate and determining the extent of C>U deamination under conditions which induce APOBEC driven C>U deamination.