Sara D Clarke

US Patent:

52664996, Nov 30, 1993

Filed:

Feb 25, 1992

Appl. No.:

7/856105

Inventors:

Charles W. Barrick - Golden CO
Sara M. Clarke - Larkspur CO
Carl W. Nordin - Golden CO

Assignee:

The United States of America as represented by the United States
Department of Energy - Washington DC

International Classification:

G01N 33553

US Classification:

436525

Abstract:

An apparatus and method for detecting antibodies specific to non-protein antigens. The apparatus is an immunological plate containing a plurality of plastic projections coated with a non-protein material. Assays utilizing the plate are capable of stabilizing the non-protein antigens with detection levels for antibodies specific to the antigens on a nanogram level. A screening assay with the apparatus allows for early detection of exposure to non-protein materials. Specifically metallic elements are detected.