Sarah Blaser Murray

US Patent:

20110294833, Dec 1, 2011

Filed:

May 27, 2010

Appl. No.:

12/789021

Inventors:

Eric Topol - La Jolla CA, US
Sarah Murray - Encinitas CA, US
Bradley Patay - San Diego CA, US

Assignee:

SCRIPPS HEALTH - La Jolla CA

International Classification:

A61K 31/519
A61P 25/28
A61P 9/00
A61P 19/10
A61P 27/00
A61P 3/10
A61P 3/04

US Classification:

5142621

Abstract:

Genome-wide association studies have been used to elucidate genes and/or pathways related to diseases; however, this methodology has yet to be used to understand the phenotype of healthy aging and/or healthspan in humans.

US Patent:

20130096142, Apr 18, 2013

Filed:

Dec 5, 2012

Appl. No.:

13/706314

Inventors:

SCRIPPS HEALTH - San Diego CA, US
Sarah Murray - Encinitas CA, US
Bradley Patay - San Diego CA, US

Assignee:

SCRIPPS HEALTH - San Diego CA

International Classification:

A61K 31/519
A61K 45/06
C12Q 1/68

US Classification:

5142621, 435 611, 506 9

Abstract:

Genome-wide association studies have been used to elucidate genes and/or pathways related to diseases; however, this methodology has yet to be used to understand the phenotype of healthy aging and/or healthspan in humans.

US Patent:

20050266432, Dec 1, 2005

Filed:

Feb 28, 2005

Appl. No.:

11/069908

Inventors:

Arnold Oliphant - Poway CA, US
Sarah Murray - Carlsbad CA, US

International Classification:

C12Q001/68

US Classification:

435006000

Abstract:

The invention provides a method of identifying a SNP haplotype that correlates with an HLA type, MHC allele or susceptibility to a particular disease or condition including the steps of (a) providing the identity of the nucleotide for each of a set of single nucleotide polymorphism (SNPs) in the major histocompatability complex (MHC) region in a population of individuals; (b) providing the HLA type, MHC allele, or susceptibility to the particular disease or condition for the individuals; and (c) identifying a SNP haplotype in the population that correlates with the HLA type, MHC allele or susceptibility to the particular disease or condition, wherein the SNP haplotype includes the SNPs in the MHC region. The invention further provides a method for predicting an HLA type, MHC allele or susceptibility to a particular disease or condition of an individual including the steps of (a) providing the identity of a plurality of SNPs in one or more nucleic acids from the individual that correlate with an HLA type, MHC allele or susceptibility to a particular disease or condition; and (b) predicting the HLA type, MHC genotype or susceptibility to a particular disease or condition for the individual based on a SNP haplotype comprising the plurality of SNPs. The invention also provides SNPs and oligonucleotide probes that are useful for identifying haplotypes associated with a particular disease or condition or with the presence of particular protein variants involved in immunological recognition. The SNPs and probes are also useful for predicting HLA-type, HLA genotype or susceptibility to a particular disease or condition.