Sarah M Stanley

US Patent:

20180353605, Dec 13, 2018

Filed:

Jul 30, 2018

Appl. No.:

16/049102

Inventors:

- New York NY, US
Sarah Stanley - New York NY, US

International Classification:

A61K 41/00
A61K 9/16
C07K 14/47
C07K 14/705
B82Y 5/00
A61K 38/17
A61K 47/69
A61N 1/40
C07K 16/18
A61K 33/26

Abstract:

The present invention provides methods and compositions for the remote control of cell function based on the use of radiofrequency waves to excite nanoparticles targeted to specific cell types. The nanoparticles may be applied to the target cell extracellularly and/or expressed intracellularly. The cell type of interest expresses a temperature sensitive channel wherein excitation of the nanoparticles results in a localized temperature increase that is transduced into a cellular response. Such cellular responses may include, for example, increases in gene expression resulting in production of one or more physiologically active proteins. The expression of such proteins can be used to treat a variety of different inherited or acquired diseases or disorders in a subject. Accordingly, the invention provides a generic approach for treatment of any disease associated with a protein deficiency.

US Patent:

20160346391, Dec 1, 2016

Filed:

May 31, 2016

Appl. No.:

15/168950

Inventors:

- New York NY, US
Sarah Stanley - New York NY, US

International Classification:

A61K 41/00
A61N 1/40
A61K 47/48
C07K 16/18
A61K 9/16
A61K 38/17

Abstract:

The present invention provides methods and compositions for the remote control of cell function based on the use of radiofrequency waves to excite nanoparticles targeted to specific cell types. The nanoparticles may be applied to the target cell extracellularly and/or expressed intracellularly. The cell type of interest expresses a temperature sensitive channel wherein excitation of the nanoparticles results in a localized temperature increase that is transduced into a cellular response. Such cellular responses may include, for example, increases in gene expression resulting in production of one or more physiologically active proteins. The expression of such proteins can be used to treat a variety of different inherited or acquired diseases or disorders in a subject. Accordingly, the invention provides a generic approach for treatment of any disease associated with a protein deficiency.

US Patent:

20140348825, Nov 27, 2014

Filed:

Aug 24, 2012

Appl. No.:

14/239427

Inventors:

Jeffrey Friedman - New York NY, US
Sarah Stanley - New York NY, US

Assignee:

THE ROCKEFELLER UNIVERSITY - New York NY

International Classification:

A61K 41/00
A61K 33/26

US Classification:

4241341, 424647, 424 937, 435375, 435325

Abstract:

The present invention provides methods and compositions for the remote control of cell function based on the use of radiofrequency waves to excite nanoparticles targeted to specific cell types. The nanoparticles may be applied to the target cell extracellularly and/or expressed intracellularly. The cell type of interest expresses a temperature sensitive channel wherein excitation of the nanoparticles results in a localized temperature increase that is transduced into a cellular response. Such cellular responses may include, for example, increases in gene expression resulting in production of one or more physiologically active proteins. The expression of such proteins can be used to treat a variety of different inherited or acquired diseases or disorders in a subject. Accordingly, the invention provides a generic approach for treatment of any disease associated with a protein deficiency.