Sarah B West

US Patent:

6448405, Sep 10, 2002

Filed:

Oct 8, 1997

Appl. No.:

08/947428

Inventors:

Todd K. Jones - Solana Beach CA
Lin Zhi - San Diego CA
James P. Edwards - San Diego CA
Christopher M. Tegley - San Diego CA
Sarah J. West - San Diego CA

Assignee:

Ligand Pharmaceuticals Incorporated - San Diego CA

International Classification:

C07D491052

US Classification:

546 62, 549390

Abstract:

Non-steroidal compounds which are high affinity, high selectivity modulators for steroid receptors are disclosed. Also disclosed are pharmaceutical compositions incorporating such compounds, methods for employing the disclosed compounds and compositions for treating patients requiring steroid receptor agonist or antagonist therapy, intermediates useful in the preparation of the compounds and processes for the preparation of the steroid receptor modulator compounds.

US Patent:

6566372, May 20, 2003

Filed:

Aug 24, 2000

Appl. No.:

09/649466

Inventors:

Lin Zhi - San Diego CA
Christopher Tegley - San Diego CA
Barbara Pio - San Diego CA
Cornelis Arjan Van Oeveren - San Diego CA
Mehrnouch Motamedi - San Diego CA
Esther Martinborough - San Diego CA
Sarah West - San Diego CA

Assignee:

Ligand Pharmaceuticals Incorporated - San Diego CA

International Classification:

A61K 3147

US Classification:

514312, 514212, 514254, 514311, 514313, 514314, 540599, 544363, 546144, 546157, 546159, 546152, 546167, 546171, 546173, 546180, 546181

Abstract:

The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by AR and PR. More particularly, the invention relates to nonsteroidal compounds and compositions that are high affinity, high specificity agonists, partial agonists (i. e. , partial activators and/or tissue-specific activators) and antagonists for AR and PR. Also provided are methods of making such compounds and pharmaceutical compositions, as well as critical intermediates used in their synthesis.

US Patent:

6696459, Feb 24, 2004

Filed:

Oct 14, 1997

Appl. No.:

08/950032

Inventors:

Todd K. Jones - Solana Beach CA
Mark E. Goldman - San Diego CA
Charlotte L. F. Pooley - San Diego CA
David T. Winn - San Diego CA
James P. Edwards - San Diego CA
Sarah J. West - San Diego CA
Christopher M. Tegley - San Diego CA
Lin Zhi - San Diego CA
Lawrence G. Hamann - San Diego CA
Luc J. Farmer - La Jolla CA
Robert L. Davis - Santee CA

Assignee:

Ligand Pharmaceuticals Inc. - San Diego CA

International Classification:

A61K 314353

US Classification:

514285, 514291, 514242, 514243, 51425501, 514256, 514259, 514267, 514292, 514299, 514300, 514301, 514302, 514303, 514314, 514312, 514311

Abstract:

Non-steroidal compounds which are high affinity, high selectivity modulators for steroid receptors are disclosed. Also disclosed are pharmaceutical compositions incorporating such compounds, methods for employing the disclosed compounds and compositions for treating patients requiring steroid receptor agonist or antagonist therapy, intermediates useful in the preparation of the compounds and processes for the preparation of the steroid receptor modulator compounds.

US Patent:

20030130505, Jul 10, 2003

Filed:

Nov 18, 2002

Appl. No.:

10/299909

Inventors:

Lin Zhi - San Diego CA, US
Christopher Tegley - San Diego CA, US
Barbara Pio - San Diego CA, US
Mehrnouch Motamedi - San Diego CA, US
Esther Martinborough - San Diego CA, US
Sarah West - San Diego CA, US
Robert Higuchi - Solana Beach CA, US
Lawrence Hamann - Cherry Hill NJ, US
Luc Farmer - Foxborough MA, US

International Classification:

A61K031/551
A61K031/4709
A61K031/4706
A61K031/538
A61K031/366

US Classification:

540/575000, 544/284000, 546/157000, 544/105000, 549/283000, 514/312000, 514/218000, 514/230500, 514/456000

Abstract:

The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by AR and PR. More particularly, the invention relates to nonsteroidal compounds and compositions that are high affinity, high specificity agonists, partial agonists (i.e., partial activators and/or tissue-specific activators) and antagonists for AR and PR. Also provided are methods of making such compounds and pharmaceutical compositions, as well as critical intermediates used in their synthesis.

US Patent:

20040186132, Sep 23, 2004

Filed:

Dec 17, 2003

Appl. No.:

10/739933

Inventors:

Todd Jones - Solana Beach CA, US
Mark Goldman - San Diego CA, US
Charlotte Pooley - San Diego CA, US
David Winn - San Diego CA, US
James Edwards - San Diego CA, US
Sarah West - San Diego CA, US
Christopher Tegley - San Diego CA, US
Lin Zhi - San Diego CA, US
Lawrence Hamann - San Diego CA, US
Luc Farmer - La Jolla CA, US
Robert Davis - Santee CA, US

International Classification:

A61K031/47

US Classification:

514/312000, 514/314000

Abstract:

Non-steroidal compounds which are high affinity, high selectivity modulators for steroid receptors are disclosed. Also disclosed are pharmaceutical compositions incorporating such compounds, methods for employing the disclosed compounds and compositions for treating patients requiring steroid receptor agonist or antagonist therapy, intermediates useful in the preparation of the compounds and processes for the preparation of the steroid receptor modulator compounds.

US Patent:

56936478, Dec 2, 1997

Filed:

Jun 5, 1995

Appl. No.:

8/464546

Inventors:

Todd K. Jones - Solana Beach CA
Lin Zhi - San Diego CA
Christopher M. Tegley - San Diego CA
David T. Winn - San Diego CA
Lawrence G. Hamann - San Diego CA
James P. Edwards - San Diego CA
Sarah J. West - San Diego CA

Assignee:

Ligand Pharmaceuticals Incorporated - San Diego CA

International Classification:

A61K 3147
C07D47104
C07D22116
C07D49148
C07D49152

US Classification:

514285

Abstract:

Non-steroidal compounds which are high affinity, high selectivity modulators for steroid receptors are disclosed. Also disclosed are pharmaceutical compositions incorporating such compounds, methods for employing the disclosed compounds and compositions for treating patients requiring steroid receptor agonist or antagonist therapy, intermediates useful in the preparation of the compounds and processes for the preparation of the steroid receptor modulator compounds.

US Patent:

56936460, Dec 2, 1997

Filed:

Jun 5, 1995

Appl. No.:

8/464360

Inventors:

Todd K. Jones - Solana Beach CA
Christopher M. Tegley - San Diego CA
Lin Zhi - San Diego CA
James P. Edwards - San Diego CA
Sarah J. West - San Diego CA

Assignee:

Ligand Pharmaceuticals Incorporated - San Diego CA

International Classification:

A61K 3144
C07D49152

US Classification:

514285

Abstract:

Non-steroidal compounds which are high affinity, high selectivity modulators for steroid receptors are disclosed. Also disclosed are pharmaceutical compositions incorporating such compounds, methods for employing the disclosed compounds and compositions for treating patients requiring steroid receptor agonist or antagonist therapy, intermediates useful in the preparation of the compounds and processes for the preparation of the steroid receptor modulator compounds.

US Patent:

56961278, Dec 9, 1997

Filed:

Jun 5, 1995

Appl. No.:

8/465429

Inventors:

Todd K. Jones - Solana Beach CA
Lin Zhi - San Diego CA
James P. Edwards - San Diego CA
Christopher M. Tegley - San Diego CA
Sarah J. West - San Diego CA

Assignee:

Ligand Pharmaceuticals Incorporated - San Diego CA

International Classification:

A61K 3144
A61K 3147
C07D47152

US Classification:

514285

Abstract:

Non-steroidal compounds which are high affinity, high selectivity modulators for steroid receptors are disclosed. Also disclosed are pharmaceutical compositions incorporating such compounds, methods for employing the disclosed compounds and compositions for treating patients requiring steroid receptor agonist or antagonist therapy, intermediates useful in the preparation of the compounds and processes for the preparation of the steroid receptor modulator compounds.