Satoshi Kashiwagi

US Patent:

20130195926, Aug 1, 2013

Filed:

Dec 4, 2012

Appl. No.:

13/693692

Inventors:

The General Hospital Corporation - Boston MA, US
Dai Fukumura - Newton MA, US
Satoshi Kashiwagi - Boston MA, US

Assignee:

The General Hospital Corporation - Boston MA

International Classification:

A61K 31/15
A61K 38/44
A61K 31/713

US Classification:

424400, 514 192, 514 44 A, 514611, 514 81, 514 89, 514 82, 514 76, 514178, 514249, 424718, 514423, 514277, 514419, 514460, 514510, 514275, 424 944, 514 44 R, 600 1

Abstract:

The instant invention provides methods for treating a solid tumor in a subject comprising modulating nitric oxide production in the tumor to normalize tumor vasculature and administering an anti-tumor therapy to the subject. The invention further provides methods of treating a solid tumor in a subject comprising selectively increasing cyclic guanosine monophosphate (cGMP) or cGMP dependent protein kinase G production in the tumor vasculature to an amount effective to normalize tumor vasculature and administering an anti-tumor therapy to the subject.

US Patent:

20100087370, Apr 8, 2010

Filed:

Feb 14, 2008

Appl. No.:

12/525186

Inventors:

Rakesh K. Jain - Wellesley MA, US
Dai Fukumura - Newton MA, US
Satoshi Kashiwagi - Boston MA, US

Assignee:

THE GENERAL HOSPITAL CORPORATION - Boston MA

International Classification:

A61K 38/18
A61K 31/7088
A61P 35/00

US Classification:

514 12, 514 44 R

Abstract:

The instant invention provides methods for treating a solid tumor in a subject comprising modulating nitric oxide production in the tumor to normalize tumor vasculature and administering an anti-tumor therapy to the subject. The invention further provides methods of treating a solid tumor in a subject comprising selectively increasing cyclic guanosine monophosphate (cGMP) or cGMP dependent protein kinase G production in the tumor vasculature to an amount effective to normalize tumor vasculature and administering an anti-tumor therapy to the subject.

US Patent:

20140276358, Sep 18, 2014

Filed:

Aug 31, 2012

Appl. No.:

14/241907

Inventors:

Satoshi Kashiwagi - Boston MA, US
Mark C. Poznansky - Charlestown MA, US

Assignee:

THE GENERAL HOSPITAL CORPORATION - Boston MA

International Classification:

A61N 5/06

US Classification:

604 20

Abstract:

Methods for enhancing an immune response to a vaccine using co-administration of radiation.