Scott A Clark

US Patent:

20090068255, Mar 12, 2009

Filed:

Apr 30, 2008

Appl. No.:

12/112374

Inventors:

Betty Yu - Cambridge MA, US
Amir Nashat - Newton MA, US
Daniel Griffith Anderson - Sudbury MA, US
David Thomas Puerta - Melrose MA, US
Benjamin Adams - Cambridge MA, US
Scott Clark - Pittsfield MA, US
Yushan Kim - Cambridge MA, US
Eric George Spengler - Ridgefield CT, US
Ronald P. McLaughlin - Reading MA, US
Susan Eilidh Bedford - Carlisle MA, US
Zhi Li - San Diego CA, US

International Classification:

A61K 8/14
A61K 8/49
A61K 31/351
A61Q 19/08
A61Q 17/04
A61P 17/02
A61P 35/00
A61P 17/00
A61Q 19/00
A61K 31/4412
A61K 9/127

US Classification:

424450, 514459, 514350, 424 59

Abstract:

The application of matrix metalloproteinase (MMP) inhibitors to the skin inhibits the degradation of proteins found in the skin including collagen, elastin, and other basement membrane and extracellular matrix protein. MMP inhibitors may be used in both cosmetic compositions and pharmaceutical compositions for application to skin. MMP inhibitors are formulated with a cosmetically suitable vehicle or pharmaceutically acceptable excipient for application to the skin as creams, lotions, ointments, solutions, face masks, etc. As cosmetics, the inventive MMP inhibitor compositions are applied to the skin to prevent or reduce the appearance of wrinkles, pigmentation changes, loss of elasticity, or other effects associated with aging or sun damage. As pharmaceuticals, the inventive MMP inhibitor compositions may also be applied to the skin to treat or prevent a skin disease (e.g., proliferative disease, inflammatory disease).