The present disclosure provides compositions, methods, and systems related to genome editing technology. In particular, the present disclosure provides a novel CRISPR-based genome editing technology that involves the generation of abasic sites to facilitate genetic recombination, without the need for breaks in the DNA. The compositions, methods, and systems described herein address many of the drawbacks of currently available approaches, including off-target effects and cellular toxicity.
Hierarchical Configuration Of Networked Communication Devices
- Liberty Lake WA, US Scott Michael Collins - Apex NC, US
International Classification:
H04L 12/24 H04L 29/08
Abstract:
A device and method for receiving a configuration setting update at a networked endpoint device. The method comprises: receiving a data packet from a head-end device, including one or more parameter updates including: a parameter identification, a designated parameter value for a parameter identified by the parameter identification, and a predetermined level assignment for the designated parameter value. The method further includes updating a record of two or more records of each parameter with its designated parameter value, the two or more records associated with differentiating level assignments defining a prioritized hierarchy of parameter values for the parameter at the endpoint device, where the updated record is associated with the predetermined level assignment. The method further includes running an application using a selected parameter value recorded at a highest priority level assignment of the differentiating level assignments for which parameter values are presently recorded at the endpoint device.
Hierarchical Configuration Of Networked Communication Devices
- Liberty Lake WA, US Scott M. Collins - Wake Forest NC, US
Assignee:
Itron, Inc. - Liberty Lake WA
International Classification:
H04L 12/24 H04L 29/08
Abstract:
A device and method for receiving a configuration setting update at a networked endpoint device. The method comprises: receiving a data packet from a head-end device, including one or more parameter updates including: a parameter identification, a designated parameter value for a parameter identified by the parameter identification, and a predetermined level assignment for the designated parameter value. The method further includes updating a record of two or more records of each parameter with its designated parameter value, the two or more records associated with differentiating level assignments defining a prioritized hierarchy of parameter values for the parameter at the endpoint device, where the updated record is associated with the predetermined level assignment. The method further includes running an application using a selected parameter value recorded at a highest priority level assignment of the differentiating level assignments for which parameter values are presently recorded at the endpoint device.
Utilizing A Multi-System Set Configuration To Update A Utility Node System Set
- Liberty Lake WA, US Samuel Lee Whitfield - Wake Forest NC, US Gregory Shane Barrett - Hayesville NC, US Kevin David Guthrie - Seneca SC, US Scott Michael Collins - Apex NC, US
International Classification:
G06F 9/445
US Classification:
717170, 717172
Abstract:
A system set of a utility node device, such as a kernel and/or root file system, may be updated by utilizing a multi-system set configuration. For example, the multi-system set configuration may include a first system set that is generally configured to act as an “active” set, a second system set (e.g., “idle” set) that is configured to operate when the first system set is non-operational or in an “idle” state, and a third system set that is configured to operate when the first and second system sets are non-operational. During an update of a system set, an update package may be applied to the second “idle” system set, while the first “active” system set remains operational. The utility node device may comprise a smart utility meter, sensor, control device, transformer, switch, relay, or the like.
Utility Node Software/Firmware Update Through A Multi-Type Package
- Liberty Lake WA, US Samuel Lee Whitfield - Wake Forest NC, US Gregory Shane Barrett - Hayesville NC, US Kevin David Guthrie - Seneca SC, US Scott Collins - Seneca SC, US
Assignee:
ITRON, INC. - Liberty Lake WA
International Classification:
G06F 9/445
US Classification:
717170, 717172, 717173
Abstract:
Software and/or firmware of a utility node device may be updated by utilizing an update package that includes multiple update items related to different types of the software and/or firmware. The utility node device may selectively install one or more of the multiple update items based on a type of the software and/or firmware that is currently installed on the device. The different types of software and/or firmware may relate to different versions of the software and/or firmware and/or different types of hardware. In some instances, an update item of the update package comprises a delta file that contains differences between different versions of the software and/or firmware. The utility node device may comprise a smart utility meter, sensor, control device, transformer, switch, relay, or the like.
Utilizing A Multi-System Set Configuration To Update A Utility Node System Set
- Liberty Lake WA, US Samuel Lee Whitfield - Wake Forest NC, US Gregory Shane Barrett - Hayesville NC, US Kevin David Guthrie - Seneca SC, US Scott Collins - Seneca SC, US
Assignee:
ITRON, INC. - Liberty Lake WA
International Classification:
G06F 9/445
US Classification:
717170, 717172
Abstract:
A system set of a utility node device, such as a kernel and/or root file system, may be updated by utilizing a multi-system set configuration. For example, the multi-system set configuration may include a first system set that is generally configured to act as an “active” set, a second system set (e.g., “idle” set) that is configured to operate when the first system set is non-operational or in an “idle” state, and a third system set that is configured to operate when the first and second system sets are non-operational. During an update of a system set, an update package may be applied to the second “idle” system set, while the first “active” system set remains operational. The utility node device may comprise a smart utility meter, sensor, control device, transformer, switch, relay, or the like.
United Parcel Service Charlotte, NC Aug 1996 to Jan 2014 On-Site Operations ManagerUnited Parcel Service Wilkesboro, NC Apr 2011 to Aug 2012 On-Site Operations ManagerUnited Parcel Service Lenoir, NC Dec 2006 to Apr 2011 On-Site Operations ManagerUnited Parcel Service Hickory, NC Oct 2004 to Dec 2006 Pre-Load and On-Road SupervisorUnited Parcel Service Wilkesboro, NC Jan 2003 to Oct 2004 On-Road SupervisorUnited Parcel Service Statesville, NC Aug 2000 to Jan 2003 Reload and On-Road SupervisorUnited Parcel Service Winston-Salem, NC Jul 1997 to Aug 2000 Part-Time SupervisorUnited Parcel Service Winston-Salem, NC Aug 1996 to Jul 1997 Package Handler
Education:
Embry Riddle Aeronautical University Daytona Beach, FL Jun 1996 Bachelor of Science in Aeronautical ScienceLenoir County Community College Kinston, NC May 1994 Associate
Skills:
Operational Strategy Process and Procedure Development Warehousing and Transportation Scheduling and Inventory Management Safety and Methods Facilitation Internal and External Customer Service
Scott Collins's official profile including the latest music, albums, songs, music videos and more updates.
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Scott Collins
Work:
Linkage - President/CEO (2004) Linkage - Dir. Member Services (2002-2004) GE Capital - VP & SR. Acct. Executive (1999-2002) GE Capital Modular Space - VP Operations (1997-1999) Bob Collins & Sons, Inc. - VP Operations (1992-1996) SPEK Properties - Property Manager (1988-1992)
Education:
Wheaton College - Social Science
Scott Collins
Work:
Nationwide Mutual Insurance Company - IT Specialist, Application Developer (2006) Lucent Technologies - Member of Technical Staff (1984-2006)
Education:
Purdue University - MSCS, Purdue University - BSCS, Indiana University-Purdue University Indianapolis - BSEE, University of Akron - BSEE
Tagline:
Do not think more highly of yourself than you ought, but have sober judgement.
Scott Collins
Work:
Dicks Sporting Goods - Golf Sales Associate
Education:
Purdue University - Computer Informations, Ivy Tech Community College - Sociology
About:
Hey ya'll, the name's Scott. Currently residing in Lafayette, Indiana at the 823 of Pheasant Run. You'll find me either rocking the battlefields of Call of Duty and Halo, or searching the ...
Tagline:
The Pokemon Master
Bragging Rights:
Team Captain for Delphi Varsity Golf Team for 3 Years, Pokemon Master, CoD Pro.
Scott Collins
Work:
Mr. Nass Carriage - Turn Left
Education:
Madison - Studied real good
Relationship:
Single
About:
Madison education!! Turn left
Tagline:
Go hard or go home.. Home is where the heart is..A heart beats 9 million times per life..Live life to the fullest..A half-full cup is also half empty..It's harder to change the world for better than for worse. So, go hard, or go home.
cluding hypertension, abnormal cholesterol, smoking and tobacco use, excessive alcohol use, poor diet, obesity, diabetes and physical activity is paramount to prevent issues for men in this age group, says Dr. C. Scott Collins, director, Mayo Clinic General Internal Medicine Mens Health Clinic.
This allows us to come to the marketplace with completely uninterrupted Walking Dead universe content from post-Super Bowl Sunday to Thanksgiving, says Scott Collins, president of ad sales for AMC Networks, in an interview.
Date: Apr 08, 2019
Category: Entertainment
Source: Google
Stranded Humpback Whale Euthanized, Residents Say Help Came Too Late
"This thing was just done so poorly," said Scott Collins of Remsenburg, who was at the scene Tuesday and said birds were pecking at the whale. "If this were to happen in California it would been saved an hour after it was beached."
Date: Nov 23, 2016
Source: Google
Ailes' departure poses unexpected challenges for Fox
Id be surprised if we saw a dramatic change in what theyre doing, says Scott Collins, TV editor at media news site The Wrap and author of Crazy Like a Fox: The Inside Story of How Fox News Beat CNN. Even if (Fox broadcaster) Bill OReilly walked out, the impulse will be reshuffle to patch holes
Date: Jul 21, 2016
Category: Business
Source: Google
The birthplace of North American surfing ranked dirtiest beach, again
"This community prides itself on environmental consciousness. This is one of our iconic beaches and it's an embarrassment to be on this list," assistant to the city manager Scott Collins about the beach celebrated as the birthplace of North American surfing.
Date: May 27, 2016
Category: U.S.
Source: Google
'Fuller House' renewed for season 2 – how the renewal and cancellation process is changing
Los Angeles Times writer Scott Collins pointed to one reason when discussing this past fall season. Thanks to digital recording and streaming, millions of viewers no longer watch shows when they are first telecast making network executives reluctant to kill a program that may be quietly building
Date: Mar 03, 2016
Category: Entertainment
Source: Google
Interstate 94 reopened after wreckage cleared from pile-up
"His truck hit a semi and was then struck by at least three other vehicles, he said. "We had to climb out the back of our windows and the sunroof," he said.Scott Collins, 17, of Chesterton, Ind., told reporters he was riding in a car with three other teens and saw the crash happen just behind them.
Date: Jan 24, 2014
Category: U.S.
Source: Google
Ecosystems dependent on snow and ice 'most threatened'
Scott Collins, Chair of the LTER Executive Board, observes that each additional year of LTER data helps us to better understand how ecosystems respond to environmental change. Such understanding provides valuable information for federal agencies, land managers, and legislators who want to dev
Date: Apr 07, 2012
Category: Sci/Tech
Source: Google
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Sam Harris stars as Perry Pearl in The Class ...
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15 Oct, 2007
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YOU INSPIRE US - Erpenbach to the People #8
This is Senator Jon Erpenbach's tribute to the working families of Wis...
Category:
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Uploaded:
04 Mar, 2011
Duration:
1m 27s
The Collector (31st July 2009) - Official Tra...
THE COLLECTOR 31st Jul 2009 Official Trailer in HD Genre:Horror, Thril...
Category:
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Uploaded:
21 Jul, 2009
Duration:
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Great Wall of Basketball (Beat Cornell)
"Great Wall of Basketball" - "Beat Cornell" version - Available for pu...