Scott Robert Gordon

US Patent:

20170319643, Nov 9, 2017

Filed:

Oct 18, 2016

Appl. No.:

15/297054

Inventors:

- Bethesda MD, US
Scott M. Gordon - Gaithersburg MD, US

Assignee:

The United States of America, as represented by the Secretary, Department of Health and Human Serv - Bethesda MD

International Classification:

A61K 38/00
A61K 38/10
A61K 38/07
A61K 38/08
A61K 38/58
A61K 38/17

Abstract:

Described herein is the design and construction of a class of lipoprotein targeting protease inhibitors. Small peptides with protease inhibitor activity are conjugated to hydrophobic, lipoprotein targeting molecules using, for instance, amine reactive chemistry. Methods of use of the resultant lipoprotein targeting protease inhibitor (antiprotease) molecules are also described. Also described is the production and use of protease inhibitor enriched HDL particles, as well as A1AT-peptide-enriched HDL particles, and their use in various therapeutic contexts.