Scott Bradley Gustafson

US Patent:

20080139524, Jun 12, 2008

Filed:

Jul 2, 2007

Appl. No.:

11/825146

Inventors:

George S. Bailey - Corvallis OR, US
Carole Jubert - Corvallis OR, US
John E. Mata - Corvallis OR, US
Scott Gustafson - Corvallis OR, US
J. S. Dunfield - Corvallis OR, US

International Classification:

A61K 31/555
C07D 487/22
A61P 43/00

US Classification:

514185, 540145

Abstract:

Pharmaceutical formulation for the prophylaxis, pretreatment and treatment of a poisoning caused by exposure to (either singly or as a mixture of agents) organophosphorus cholinesterase inhibitors, vesicating agents, polycyclic aromatic hydrocarbons, and aflatoxin B1. This invention is characterized by active substance comprised of a metaloporphyrin molecule with an associated metal moiety (Cu, Mg) of suitable purity and chemical composition to provide a bioavailable oral dosage form to attain predictable concentrations in target tissues and bodily fluids (plasma, bronchial secretions, etc.) sufficient to counteract the effects of toxic substances through chemical complexation or catalysis of toxin degradation. Although these metaloporphyrins are semisynthetic products of chlorophyll, the preferred starting material is chlorophyll a (Chla) extracted and purified from or other sources. A specific method is invented to achieve a critical combination of purity and yield beyond those currently available.

US Patent:

20090137526, May 28, 2009

Filed:

Nov 25, 2007

Appl. No.:

11/944626

Inventors:

Carole Jubert - Corvallis OR, US
John Enrique Mata - Corvallis OR, US
Scott Bradley Gustafson - Albany OR, US
John Stephen Dunfield - Corvallis OR, US

International Classification:

A61K 31/722
C08B 37/08
A61P 1/00

US Classification:

514 55, 536 20

Abstract:

The present disclosure relates to methods for purifying chitin or chitosan, particularly for obtaining medical grade materials suitable for use in biocompatible devices,formulations, or other materials. Chitosan separation and purification methods are taught for obtaining high purity and fractionated bio-compatible medical grade materials. Chemistries and solvent systems are taught for the use in counter current chromatography, liquid/liquid or other microfluidic separation systems.