Scott F Krauser

US Patent:

20030082226, May 1, 2003

Filed:

May 6, 2002

Appl. No.:

10/138777

Inventors:

Carlos Samour - Bedford MA, US
Scott Krauser - Tyngsboro MA, US
Robert Gyurik - Exeter NH, US

International Classification:

A61K009/70

US Classification:

424/449000

Abstract:

Topical alcoholic or aqueous alcoholic gels containing ibuprofen or other NSAIDs, such as, naproxen, in substantially neutral salt form, have enhanced penetration through skin and may provide rapid pain/inflammation relief by including in the formulation 2-n-nonyl-1,3-dioxolane or other hydrocarbyl derivative of 1,3-dioxolane-or 1,3-dioxane or acetal, as skin penetration enhancing compound. The amount of propylene glycol may be varied to adjust the initial flux of the NSAID through the skin, especially for ibuprofen, naproxen, and ketorolac.

US Patent:

20050032900, Feb 10, 2005

Filed:

Oct 4, 2002

Appl. No.:

10/491493

Inventors:

Scott Krauser - Westford MA, US

International Classification:

A61K031/192
A61K009/00

US Classification:

514570000, 424400000

Abstract:

Emulsions and creams containing ibuprofen effective for topical administration of the ibuprofen are provided without the presence of conventional O/W emulsifying agent. The emulsions and creams are formed by using the ibuprofen, in the form of its salt, as the O/W emulsifying agent. A minor amount of a W/O emulsifying agent may be included in the composition. Percutaneous delivery of ibuprofen is improved by using a skin penetration enhancing compound, such as 2-n-nonyl-1,3-dioxolane or decanaldimethyl acetal, as the oily phase of the emulsion.

US Patent:

20070134308, Jun 14, 2007

Filed:

Jul 5, 2006

Appl. No.:

11/480570

Inventors:

Carlos Samour - Bedford MA, US
Scott Krauser - Tyngsboro MA, US
Robert Gyurik - Exeter NH, US

Assignee:

MacroChem Corporation - Lexington MA

International Classification:

A61K 31/192
A61F 13/02

US Classification:

424448000, 514569000

Abstract:

Topical alcoholic or aqueous alcoholic gels containing ibuprofen or other NSAIDs, such as, naproxen, in substantially neutral salt form, have enhanced penetration through skin and may provide rapid pain/inflammation relief by including in the formulation 2-n-nonyl-1,3-dioxolane or other hydrocarbyl derivative of 1,3-dioxolane or 1,3-dioxane or acetal, as skin penetration enhancing compound. The amount of propylene glycol may be varied to adjust the initial flux of the NSAID through the skin, especially for ibuprofen, naproxen, and ketorolac.

US Patent:

20070287688, Dec 13, 2007

Filed:

Jul 9, 2004

Appl. No.:

10/564199

Inventors:

Thomas Chan - Hopkinton MA, US
Scott Krauser - Lexington MA, US

International Classification:

A61K 31/05
A61K 31/19
A61K 31/195
A61K 31/20
A61K 31/4965
A61K 31/56
A61K 47/00
A61P 17/00

US Classification:

514169000, 514255050, 514558000, 514563000, 514568000, 514573000, 514731000, 514784000

Abstract:

Compounds of Formula I are useful as skin penetration enhancing agents: (I) wherein: R represents a linear, saturated or unsaturated, substituted or unsubstituted hydrocarbyl radical; and X represents a —(CO)O—, —O(CO)—, C═O, CONH, O, NHCONH, S, or S═O radical. Compositions and methods using these compounds are also described.

US Patent:

59765666, Nov 2, 1999

Filed:

Aug 29, 1997

Appl. No.:

8/921057

Inventors:

Carlos M. Samour - Bedford MA
Scott F. Krauser - Tyngsboro MA
Robert J. Gyurik - Exeter NH

Assignee:

MacroChem Corporation - Lexington MA

International Classification:

A61K 4710
A61K 4722
A61K 910

US Classification:

424449

Abstract:

Topical alcoholic or aqueous alcoholic gels containing ibuprofen or other NSAIDs, such as, naproxen, in substantially neutral salt form, have enhanced penetration through skin and may provide rapid pain/inflammation relief by including in the formulation 2-n-nonyl-1,3-dioxolane or other hydrocarbyl derivative of 1,3-dioxolane or 1,3-dioxane or acetal, as skin penetration enhancing compound. The amount of propylene glycol may be varied to adjust the initial flux of the NSAID through the skin, especially for ibuprofen, naproxen, and ketorolac.

US Patent:

58079572, Sep 15, 1998

Filed:

Dec 23, 1996

Appl. No.:

8/771990

Inventors:

Carlos M. Samour - Newport RI
Scott F. Krauser - Methuen MA

Assignee:

MacroChem Corporation - Lexington MA

International Classification:

C08G 1850

US Classification:

528 49

Abstract:

A mixture of lipophilic and amphiphilic/hydrophilic film-forming polymers of the formula (I) R--(CO). sub. m Y. sup. 1 --(CH. sub. 2 CHR. sup. 1 O). sub. n --�CONH--Z--NHCO(OCH. sub. 2 CHR. sup. 2). sub. n' --Y. sup. 2 --(CH. sub. 2 CHR. sup. 2 O). sub. n" !. sub. p --CONH--Z--NHCO--(OCH. sub. 2 CHR. sup. 1). sub. n --Y. sup. 1 (CO). sub. m R (I) where R represents (i) an alkyl, alkenyl or alkaryl group of from 1 to 30 carbon atoms or (ii) a polypropylene oxide group or polybutylene oxide group; R. sup. 1 and R. sup. 2, each, independently, represent a hydrogen atom, or a methyl or ethyl group; Z represents a divalent linking hydrocarbyl group; m is 0 or 1; when m=0, Y. sup. 1 represents O, NR. sup. 3 or N. sup. + R. sup. 3 R. sup. 4 X. sup. - and when m=1 Y. sup.

US Patent:

59689196, Oct 19, 1999

Filed:

Oct 16, 1997

Appl. No.:

8/953014

Inventors:

Carlos M. Samour - Bedford MA
Scott F. Krauser - Tyngsboro MA
Robert J. Gyurik - Exeter NH

Assignee:

MacroChem Corporation - Lexington MA

International Classification:

A61K 3156

US Classification:

514177

Abstract:

Topical alcoholic or aqueous alcoholic gels containing testosterone, progesterone, estradiol or other hormones have enhanced penetration through skin by including in the formulation 2-n-nonyl-1,3-dioxolane or other hydrocarbyl derivative of 1,3-dioxolane or 1,3-dioxane or acetal, as skin penetration enhancing compound.

US Patent:

59425458, Aug 24, 1999

Filed:

May 27, 1997

Appl. No.:

8/864130

Inventors:

Carlos M. Samour - Bedford MA
Scott F. Krauser - Tyngsboro MA
Robert J. Gyurik - Exeter NH

Assignee:

MacroChem Corporation - Lexington MA

International Classification:

A61K 31557
A61K 31495
A61K 3150
A61K 31415

US Classification:

514573

Abstract:

A composition for the topical transdermal administration to the penis is based on prostaglandin E. sub. 1. The composition is non-irritating and effective for relieving erectile impotence or other penile erectile dysfunction. A penetration enhancing effective amount of a dioxolane, dioxane, or acetal skin penetration enhancing compound in a pharmaceutically acceptable aqueous alcoholic carrier is used to facilitate the penetration of the prostaglandin E. sub. 1 active ingredient through the skin. Phentolamine or prazosin may be used in combination with prostaglandin E. sub. 1.