Scott H Norton

US Patent:

6603537, Aug 5, 2003

Filed:

Aug 20, 1999

Appl. No.:

09/378259

Inventors:

Louis J. Dietz - Mountain View CA
Ian Walton - Redwood City CA
Scott Norton - Sunnyvale CA

Assignee:

SurroMed, Inc. - Mountain View CA

International Classification:

G01J 330

US Classification:

356 39, 356317, 356417, 2504581

Abstract:

Methods and instrumentation for performing charge coupled device (CCD)-based confocal spectroscopy with a laser spot array are provided. The methods and instruments of the invention are useful in any spectroscopic application, including, but not limited to, microscopy and microvolume laser scanning cytometry (MLSC).

US Patent:

6687395, Feb 3, 2004

Filed:

Apr 26, 2000

Appl. No.:

09/558094

Inventors:

Louis J. Dietz - Mountain View CA
Ian Walton - Redwood City CA
Chih-Hua Chung - Fremont CA
Scott Norton - Sunnyvale CA
James L. Winkler - Sunnyvale CA
Aaron B. Kantor - Newark CA
Byron Lee - San Jose CA
Shalom Tsur - Mountain View CA

Assignee:

SurroMed, Inc. - Mountain View CA

International Classification:

G06K 900

US Classification:

382133, 359201

Abstract:

The present invention provides an improved integrated system for biological marker identification. The system uses Microvolume Laser Scanning Microscopy (MLSC) in order to measure patterns of expression of biological markers in biological fluids. The system includes improved instrumentation for performing MLSC, and also includes improved particle detection and analysis methods. The system further comprises an informatics architecture for the analysis of data obtained from the MLSC in tandem with other medical information.

US Patent:

6800860, Oct 5, 2004

Filed:

Aug 5, 2003

Appl. No.:

10/635917

Inventors:

Louis J. Dietz - Mountain View CA
Ian Walton - Mountain View CA
Scott Norton - Sunnyvale CA

Assignee:

SurroMed, Inc. - Menlo Park CA

International Classification:

G01N 2164

US Classification:

2504581, 2504591, 356317, 356318

Abstract:

Methods and instrumentation for performing charge coupled device (CCD)-based confocal spectroscopy with a laser spot array are provided. The methods and instruments of the invention are useful in any spectroscopic application, including, but not limited to, microscopy and microvolume laser scanning cytometry (MLSC).

US Patent:

6835927, Dec 28, 2004

Filed:

Oct 15, 2002

Appl. No.:

10/272425

Inventors:

Christopher H. Becker - Palo Alto CA
Curtis A. Hastings - Arlington VA
Scott M. Norton - Sunnyvale CA

Assignee:

Surromed, Inc. - Menlo Park CA

International Classification:

B01D 5944

US Classification:

250282, 250281, 250288

Abstract:

Relative quantitative information about components of chemical or biological samples can be obtained from mass spectra by normalizing the spectra to yield peak intensity values that accurately reflect concentrations of the responsible species. A normalization factor is computed from peak intensities of those inherent components whose concentration remains constant across a series of samples. Relative concentrations of a component occurring in different samples can be estimated from the normalized peak intensities. Unlike conventional methods, internal standards or additional reagents are not required. The methods are particularly useful for differential phenotyping in proteomics and metabolomics research, in which molecules varying in concentration across samples are identified. These identified species may serve as biological markers for disease or response to therapy.

US Patent:

6979830, Dec 27, 2005

Filed:

Oct 5, 2004

Appl. No.:

10/959293

Inventors:

Louis J. Dietz - Mountain View CA, US
Ian Walton - Redwood City CA, US
Scott Norton - Sunnyvale CA, US

Assignee:

PPD Biomarker Discovery Sciences, LLC - Wilmington NC

International Classification:

G01N021/64
G01J003/30

US Classification:

2504851, 2504591, 356 39, 356317, 356318, 356417

Abstract:

Methods and instrumentation for performing charge coupled device (CCD)-based confocal spectroscopy with a laser spot array are provided. The methods and instruments of the invention are useful in any spectroscopic application, including, but not limited to, microscopy and microvolume laser scanning cytometry (MLSC).

US Patent:

7087896, Aug 8, 2006

Filed:

Dec 27, 2004

Appl. No.:

11/023234

Inventors:

Christopher H. Becker - Palo Alto CA, US
Curtis A. Hastings - Bethesda MD, US
Scott M. Norton - Durham NC, US
Sushmita Mimi Roy - Santa Clara CA, US
Weixun Wang - Mountain View CA, US
Haihong Zhou - Mountain View CA, US
Thomas Andrew Shaler - Fremont CA, US
Praveen Kumar - Santa Clara CA, US
Markus Anderle - Campbell CA, US
Hua Lin - Sunnyvale CA, US

Assignee:

PPD Biomarker Discovery Sciences, LLC - Wilmington NC

International Classification:

B01D 59/44
H01J 49/00

US Classification:

250282, 250281

Abstract:

Relative quantitative information about components of chemical or biological samples can be obtained from mass spectra by normalizing the spectra to yield peak intensity values that accurately reflect concentrations of the responsible species. A normalization factor is computed from peak intensities of those inherent components whose concentration remains constant across a series of samples. Relative concentrations of a component occurring in different samples can be estimated from the normalized peak intensities. Unlike conventional methods, internal standards or additional reagents are not required. The methods are particularly useful for differential phenotyping in proteomics and metabolomics research, in which molecules varying in concentration across samples are identified. These identified species may serve as biological markers for disease or response to therapy.

US Patent:

7336812, Feb 26, 2008

Filed:

Feb 3, 2004

Appl. No.:

10/771585

Inventors:

Louis J Dietz - Mountain View CA, US
Ian Walton - Redwood City CA, US
Chih-Hua Chung - Fremont CA, US
Scott Norton - Sunnyvale CA, US
James L Winkler - San Diego CA, US
Aaron B Kantor - San Carlos CA, US
Byron Lee - San Jose CA, US
Shalom Tsur - Mountain View CA, US

Assignee:

PPD Biomarker Discovery Sciences, LLC - Wilmington NC

International Classification:

G06K 9/00
G06K 9/46
G06K 99/66
G06K 9/38

US Classification:

382134, 382165, 382191, 382192, 382270

Abstract:

The present invention provides an improved integrated system for biological marker identification. The system uses Microvolume Laser Scanning Microscopy (MLSC) in order to measure patterns of expression of biological markers in biological fluids. The system includes improved instrumentation for performing MLSC, and also includes improved particle detection and analysis methods. The system further comprises an informatics architecture for the analysis of data obtained from the MLSC in tandem with other medical information.

US Patent:

7516151, Apr 7, 2009

Filed:

Nov 1, 2004

Appl. No.:

10/979413

Inventors:

Scott J. Norton - San Jose CA, US
Hyun J. Kim - Sunnyvale CA, US

Assignee:

Hewlett-Packard Development Company, L.P. - Houston TX

International Classification:

G06F 17/00

US Classification:

707102, 707101, 707202

Abstract:

A computer-implemented method for traversing a first set of objects in a first dynamic list in a computer system. The method includes partitioning copies of the first set of objects into a plurality of second dynamic lists, each of the plurality of second dynamic lists being configured to contain a subset of the copies of the first set of objects, copies of the first set of objects being disposed in the plurality of second dynamic lists. The method also includes traversing the plurality of second dynamic lists using a plurality of traversal threads, thereby causing at least some of the copies of the first set of objects to be traversed in parallel.