Scott E Rogers

US Patent:

57314101, Mar 24, 1998

Filed:

Nov 28, 1994

Appl. No.:

8/345527

Inventors:

Scott W. Rogers - Salt Lake City UT
Lorise C. Gahring - Salt Lake City UT
Roy E. Twyman - Sandy UT

Assignee:

University of Utah Research Foundation - Salt Lake City UT

International Classification:

C07L 14435
A61K 3816

US Classification:

530325

Abstract:

A peptide containing 24 amino acid residues that binds to anti-neuronal-glutamate-receptor autoantibodies associated with Rasmussen's encephalitis and that blocks activation of the GluR3 subunit is described. Methods of making the peptide and treating Rasmussen's encephalitis are also disclosed. Autoantibodies to other glutamate receptor subunits are associated with paraneoplastic neurodegenerative disease, amyotrophic lateral sclerosis, and neurodegenerative disease of unknown diagnosis. Methods of screening patients and of monitoring patients being treated for these disorders and syndromes are further described.

US Patent:

55298982, Jun 25, 1996

Filed:

Aug 19, 1993

Appl. No.:

8/109234

Inventors:

Scott W. Rogers - Salt Lake City UT
James O. McNamara - Chapel Hill NC
Stephen F. Heinemann - La Jolla CA

Assignee:

Duke University - Durham NC
The Salk Institute for Biological Studies - La Jolla CA

International Classification:

G01N 3353
G01N 33564

US Classification:

435 71

Abstract:

A method of screening a subject for a central nervous system disorder caused by autoimmune disease (e. g. , an inflammatory seizure disorder) comprises a sample from the subject and then detecting the presence or absence of anti-glutamate receptor autoantibodies (e. g. , anti-GluR3 glutamate receptor autoantibodies) in the biological sample. The presence of such autoantibodies indicates the subject is afflicted with a central nervous system disorder caused by autoimmune disease. Methods of treating such disease by reducing the number of autoantibodies available to bind to glutamate receptors in the subject are also disclosed.

US Patent:

60108541, Jan 4, 2000

Filed:

Jul 3, 1997

Appl. No.:

8/887769

Inventors:

Scott W. Rogers - Salt Lake City UT
Lorise C. Gahring - Salt Lake City UT
Roy E. Twyman - Doylestown PA

Assignee:

University of Utah Research Foundation - Salt Lake City UT

International Classification:

G01N 3353

US Classification:

435 6

Abstract:

A peptide containing 24 amino acid residues that binds to anti-neuronal-glutamate-receptor autoantibodies associated with Rasmussen's encephalitis and that blocks activation of the GluR3 subunit is described. Methods of making the peptide and treating Rasmussen's encephalitis are also disclosed. Autoantibodies to other glutamate receptor subunits are associated with paraneoplastic neurodegenerative disease, amyotrophic lateral sclerosis, and neurodegenerative disease of unknown diagnosis. Methods of screening patients and of monitoring patients being treated for these disorders and syndromes are further described.