The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.
- Princeton NJ, US Carol Hui HU - New Hope PA, US Meriah Neissel Valente - Bedminster NJ, US Scott A. Shaw - Lawrence Township NJ, US Benjamin P. Vokits - New York City NY, US Oz Scott Halpern - Robbinsville NJ, US
International Classification:
C07D 471/04
Abstract:
The present invention provides compounds of Formula (I). wherein A and Z are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are myeloperoxidase (MPO) inhibitors and may be useful for the treatment and/or prophylaxis of atherosclerosis, heart failure, chronic obstructive pulmonary disease (COPD), and related diseases.
Triazolopyridine Inhibitors Of Myeloperoxidase And/Or Epx
- Princeton NJ, US Joanne M. Smalheer - Yardley PA, US Scott A. Shaw - Lawrence Township NJ, US Benjiman P. Vokits - New York City NY, US Andrew K. Dilger - Ewing NJ, US Charles G. Clark - Cherry Hill NJ, US Meriah Neissel Valente - Bedminstar NJ, US Sutjano Jusuf - Princeton NJ, US Nicholas R. Wurtz - Pennington NJ, US
International Classification:
C07D 471/04 C07D 519/00
Abstract:
The present invention provides compounds of Formula (I); wherein the substituents are each as defined in the specification, and compositions comprising any of such novel compounds. These compounds are myeloperoxidase (MPO) inhibitors and/or eosinophil peroxidase (EPX) inhibitors, and may be useful for the treatment and/or prophylaxis of atherosclerosis, heart failure, chronic obstructive pulmonary disease (COPD), and related diseases.
- Princeton NJ, US Scott A. Shaw - Lawrence Township NJ, US Oz Scott Halpern - Bordentown NJ, US Carol Hui Hu - New Hope PA, US Ellen K. Kick - Ewing NJ, US
International Classification:
C07D 471/04
Abstract:
The present invention provides compounds of Formula (I):wherein A is as defined in the specification, and compositions comprising any of such novel compounds. These compounds are myeloperoxidase (MPO) inhibitors and/or eosinophil peroxidase (EPX) inhibitors, which may be used as medicaments.
Spiroheptane Salicylamides And Related Compounds As Inhibitors Of Rock
- Princeton NJ, US Vladimir Ladziata - Ewing NJ, US Indawati De Lucca - Pennington NJ, US Donald J.P. Pinto - Churchville PA, US Michael J. Orwat - New Hope PA, US Andrew K. Dilger - Ewing NJ, US Kumar Balashanmuga Pabbisetty - Piscataway NJ, US Wu Yang - Princeton Junction NJ, US Scott A. Shaw - Lawrence Township NJ, US Peter W. Glunz - Yardley PA, US Manoranjan Panda - Bangalore, IN
International Classification:
C07D 513/04 A61P 9/10 A61P 15/10
Abstract:
The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically-acceptable salts thereof wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.
- Princeton NJ, US Nicholas Ronald Wurtz - Pennington NJ, US Scott A. Shaw - Lawrence Township NJ, US Ellen K. Kick - Ewing NJ, US Andrew K. Dilger - Ewing NJ, US Kumar Balashanmuga Pabbisetty - Piscataway NJ, US
Assignee:
Bristol-Meyers Squibb Company - Princeton NJ
International Classification:
C07D 471/04
Abstract:
The present invention provides compounds of Formula (I): wherein A, Y and Rare each as defined in the specification, and compositions comprising any of such novel compounds. These compounds are myeloperoxidase (MPO) inhibitors and/or eosinophil peroxidase (EPX) inhibitors, which may be used as medicaments.
Triazolopyridine And Triazolopyrimidine Inhibitors Of Myeloperoxidase
- Princeton NJ, US Andrew Quoc Viet - Schwenksville PA, US Scott A. Shaw - Lawrence Township NJ, US Benjamin P. Vokits - New York City NY, US Ellen K. Kick - Ewing NJ, US Meriah Neissel Valente - Bedminister NJ, US Andrew K. Dilger - Ewing NJ, US Kumar Balashanmuga Pabbisetty - Piscataway NJ, US Sutjano Jusuf - Ardmore PA, US
International Classification:
C07D 519/00 C07D 487/04 C07D 471/04
Abstract:
The present invention provides compounds of Formula (I): wherein A and Rare each as defined in the specification, and compositions comprising any of such novel compounds. These compounds are myeloperoxidase (MPO) inhibitors and/or eosinophil peroxidase (EPX) inhibitors, which may be used as medicaments.
Dr. Shaw graduated from the Wright State University Boonshoft School of Medicine in 1984. He works in Dayton, OH and specializes in Internal Medicine and Family Medicine. Dr. Shaw is affiliated with Good Samaritan Hospital, Kettering Medical Center and Miami Valley Hospital.
Isbn (Books And Publications)
Let's Elope: The Definitive Guide to Eloping, Destination Weddings, and Other Creative Wedding Options
Reno Police Department Lt. Scott Shaw asked for the public's help in finding a dark-colored Toyota Camry or Corolla that should have damage to a side window and possible damage to brake lights or taillights. It's unclear whether the shooter was also injured when he drove off, fleeing the scene.
Date: Nov 25, 2016
Category: U.S.
Source: Google
Black Friday Violence: 2 Dead Following Shootings in New Jersey, Nevada and Tennessee
Lt. Scott Shaw of the Reno Police Department toldKOLOthat shortly after 6 p.m. Thursday, two drivers got into an argument apparently over a parking spot. According to Fox 6, both parties involved in the argument were armed and a33-year-old man was shot dead at the scene.
Date: Nov 25, 2016
Category: World
Source: Google
Shopper opens fire, killing one, over parking spot
"It looks it was some sort of road rage incident, we don't have any other information that it was linked to any shopping activities or anything like that at this point," said Lt. Scott Shaw with the Reno Police Department.
Date: Nov 25, 2016
Category: U.S.
Source: Google
Reno Police investigating after deadly Walmart shooting
---------------------------------------What started as a road rage incident at the East Second Street Walmart in Reno Thanksgiving evening turned into a fatality, Reno Police Department, Lt. Scott Shaw said.
Date: Nov 25, 2016
Source: Google
Rooftop solar fees become dominant issue for Nevada energy task force
The Energy Task Force heard lengthy public comment, almost all of it devoted to the issue of rooftop solar. Scott Shaw, director of research and commercial development for Nevada-based Go Solar, criticized the commissions ruling and urged the task force to remedy it.
My prediction is that the search will turn up something interesting, even if there is not a planet there, said J. Scott Shaw, a professor emeritus of physics and astronomy at the University of Georgia.
o closely, but theres Pat Loika posting glimpses of booths on the con floor before it opens. Theres Jill Thompson preparing prints to sell. Theres Scott Shaw! getting ready for his hilarious Oddball Comics panel. And theres 10 billion awesome announcements that were already made!
Date: Jul 23, 2014
Category: Entertainment
Source: Google
Today in photo history – 1987: Baby Jessica rescued from well
As Eric and I stood on our ladders I noticed another photographer standing across from us in a cherry picker that belong to a local utility company. Eric said it was Scott Shaw, the hometown newspaper photographer who worked for the Odessa American. I knew he had a great vantage point and he was hig
I have fished from the Minnesota/Canada border to as far south as Southern Florida. Fishing small subdivision ponds to large lakes and oceans. Over the past six to seven years I have taught myself all...