Scott Richard Throner

US Patent:

7781434, Aug 24, 2010

Filed:

Oct 8, 2009

Appl. No.:

12/575891

Inventors:

Joseph Cacciola - Wilmington DE, US
James Empfield - Wilmington DE, US
James Folmer - Wilmington DE, US
Angela M Hunter - Wilmington DE, US
Scott Throner - Wilmington DE, US

Assignee:

AstraZeneca AB - Sodertalje

International Classification:

A61K 31/5377
C07D 413/14

US Classification:

5142352, 544140

Abstract:

Compounds in accord with Formula I:.

US Patent:

7790760, Sep 7, 2010

Filed:

Jun 3, 2009

Appl. No.:

12/477347

Inventors:

Joseph Cacciola - Wilmington DE, US
James Empfield - Wilmington DE, US
James Folmer - Wilmington DE, US
Angela M. Hunter - Wilmington DE, US
Scott Throner - Wilmington DE, US

Assignee:

AstraZeneca AB - Sodertalje

International Classification:

A61K 31/422
C07D 261/18

US Classification:

514378, 548248

Abstract:

Compounds in accord with Formula I:.

US Patent:

7888353, Feb 15, 2011

Filed:

Aug 26, 2010

Appl. No.:

12/869263

Inventors:

Joseph Cacciola - Wilmington DE, US
James Empfield - Wilmington DE, US
James Folmer - Wilmington DE, US
Angela M Hunter - Wilmington DE, US
Scott Throner - Wilmington DE, US

Assignee:

AstraZeneca AB - Sodertalje

International Classification:

A61K 31/5377
C07D 413/14

US Classification:

5142352, 544137

Abstract:

Compounds in accord with Formula I:.

US Patent:

8063215, Nov 22, 2011

Filed:

Aug 21, 2008

Appl. No.:

12/195454

Inventors:

James Arnold - San Francisco CA, US
Todd Andrew Brugel - Wilmington DE, US
Scott Throner - Wilmington DE, US
Steven Wesolowski - Wilmington DE, US
Phil Edwards - Kennett Square PA, US
Andrew Griffin - Québec, CA
Thierry Groblewski - Québec, CA
Denis Labrecque - Québec, CA

Assignee:

AstraZeneca AB - Sodertalje

International Classification:

C07D 241/04
C07D 295/00

US Classification:

544391

Abstract:

Disclosed herein is at least one cyclopropyl amide derivative, at least one pharmaceutical composition comprising at least one cyclopropyl amide derivative disclosed herein, and at least one method of using at least one cyclopropyl amide derivative disclosed herein for treating at least one histamine H3 receptor associated condition therewith.

US Patent:

8148372, Apr 3, 2012

Filed:

Aug 20, 2010

Appl. No.:

12/860330

Inventors:

Joseph Cacciola - Wilmington DE, US
James Empfield - Wilmington DE, US
James Folmer - Wilmington DE, US
Angela M Hunter - Wilmington DE, US
Scott Throner - Wilmington DE, US

Assignee:

AstraZeneca AB - Sodertalje

International Classification:

A61K 31/5377
C07D 413/14
A61K 31/422
C07D 261/18

US Classification:

5142352, 514378, 544137, 544140, 548248

Abstract:

Compounds in accord with Formula I:.

US Patent:

20070105896, May 10, 2007

Filed:

Nov 15, 2004

Appl. No.:

10/579609

Inventors:

James Empfield - Wilmington DE, US
Eifion Phillips - Bothwyn PA, US
Scott Throner - Wilmington DE, US

Assignee:

AstraZeneca AB - Sodertalje

International Classification:

A61K 31/4745
A61K 31/46
A61K 31/4178
C07D 453/02

US Classification:

514304000, 514305000, 514397000, 546125000, 546133000, 548311100

Abstract:

Compounds of formula I: wherein A and Rare as defined in the specification, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, especially in the treatment or prophylaxis of psychotic and intellectual impairment disorders.

US Patent:

20080188518, Aug 7, 2008

Filed:

Nov 15, 2004

Appl. No.:

10/579608

Inventors:

James Empfield - Wilmington DE, US
Eifion Phillips - Bothwyn PA, US
Scott Throner - Wilmington DE, US

Assignee:

ASTRA ZENECA AB - Sodertaije Sweden

International Classification:

A61K 31/439
C07D 453/02
A61P 25/34
A61P 25/16
A61P 25/18
A61P 25/00
A61P 25/28

US Classification:

514305, 546133

Abstract:

Compounds of formula I:wherein A and Rare as defined in the specification, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, especially in the treatment or prophylaxis of psychotic and intellectual impairment disorders.

US Patent:

20090062282, Mar 5, 2009

Filed:

Oct 14, 2005

Appl. No.:

11/577154

Inventors:

Jeffrey Scott Albert - Wilmington DE, US
Don Andisik - Wilmington DE, US
James Arnold - Wilmington DE, US
Dean Brown - Wilmington DE, US
Owen Callaghan - Den Bosch, NL
James Campbell - Wilmington DE, US
Robin Arthur Ellis Carr - Bassingbourn, GB
Gianni Chessari - Cambridge, GB
Miles Stuart Congreve - Cambridge, GB
Phil Edwards - Wilmington DE, US
James R. Empfield - Wilmington DE, US
Martyn Frederickson - Cambridge, GB
Gerard M. Koether - Wilmington DE, US
Jennifer Krumrine - Wilmington DE, US
Russ Mauger - Wilmington DE, US
Christopher William Murray - Cambridge, GB
Sahil Patel - Cambridge, GB
Mark Sylvester - Wilmington DE, US
Scott Throner - Wilmington DE, US

Assignee:

AstraZeneca AB - Sodertalje

International Classification:

A61K 31/5377
C07D 239/22
A61K 31/513
C12N 9/99
A61P 25/28
C07D 413/10

US Classification:

5142358, 544321, 514272, 544123, 435184

Abstract:

This invention relates to novel compounds having the structural formula Ia or formula Ib below: (Ia, Ib), and their pharmaceutically acceptable salts, tautomers or in vivo hydrolysable precursors, compositions and methods of use thereof. These novel compounds provide a treatment or prophylaxis of Aβ related pathologies such as cognitive impairment, Alzheimer Disease, neurodegeneration and dementia.