Sean M Ford

US Patent:

8071035, Dec 6, 2011

Filed:

Apr 14, 2008

Appl. No.:

12/102822

Inventors:

Arkadij M Elizarov - Valley Village CA, US
Carroll Edward Ball - Del Mar CA, US
Jianzhong Zhang - Brea CA, US
Hartmuth C. Kolb - Playa Del Rey CA, US
R. Michael Van Dam - Glendale CA, US
Lawrence Talcott Diener - Long Beach CA, US
Sean Ford - Lake Zurich IL, US
Reza Miraghaie - Culver City CA, US

Assignee:

Siemens Medical Solutions USA, Inc. - Malvern PA

International Classification:

G21C 1/00
B01J 19/00
B01J 10/00
B01L 3/00
B01L 3/02
F16K 3/00

US Classification:

422159, 422129, 422130, 422500, 422501, 422502, 422504, 422505, 422507, 422509, 422521, 422522, 422523, 422524, 422537, 422547, 422600, 422603

Abstract:

Methods and devices for a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in a fast, efficient and compact manner are disclosed. In particular, the various embodiments of the present invention provide an automated, stand-alone, hands-free operation of the entire radiosynthesis cycle on a microfluidic device with unrestricted gas flow through the reactor, starting with target water and yielding purified PET radiotracer within a period of time shorter than conventional chemistry systems. Accordingly, one aspect of the present invention is related to a microfluidic chip for radiosynthesis of a radiolabeled compound, comprising a reaction chamber, one or more flow channels connected to the reaction chamber, one or more vents connected to said reaction chamber, and one or more integrated valves to effect flow control in and out of said reaction chamber.

US Patent:

8173073, May 8, 2012

Filed:

Oct 29, 2010

Appl. No.:

12/915149

Inventors:

Arkadij M. Elizarov - Woodland Hills CA, US
Carroll Edward Ball - Los Angeles CA, US
Jianzhong Zhang - Brea CA, US
Hartmuth C. Kolb - Playa Del Rey CA, US
R. Michael Van Dam - Los Angeles CA, US
Lawrence Diener - Long Beach CA, US
Sean Ford - Oceanside CA, US
Reza Miraghaie - Culver City CA, US

Assignee:

Siemens Medical Solutions USA, Inc. - Malvern PA

International Classification:

G21C 1/00
B01J 19/00
B01J 8/00
G01N 23/00
G01N 30/02

US Classification:

422159, 422129, 422130, 422600, 422603, 436 57, 436161

Abstract:

Methods and devices for a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in a fast, efficient and compact manner are disclosed. In particular, the various embodiments of the present invention provide an automated, stand-alone, hands-free operation of the entire radiosynthesis cycle on a microfluidic device with unrestricted gas flow through the reactor, starting with target water and yielding purified PET radiotracer within a period of time shorter than conventional chemistry systems. Accordingly, one aspect of the present invention is related to a microfluidic chip for radiosynthesis of a radiolabeled compound, comprising a reaction chamber, one or more flow channels connected to the reaction chamber, one or more vents connected to said reaction chamber, and one or more integrated valves to effect flow control in and out of said reaction chamber.