Sean Edward Mackey

US Patent:

20130102994, Apr 25, 2013

Filed:

Aug 30, 2012

Appl. No.:

13/600060

Inventors:

Martin J. Gibler - West Chester OH, US
Mark A. Bennett - Loveland OH, US
Kenneth R. Waeber - Milford OH, US
Kenneth E. Hogue - Chapel Hill NC, US
Christoph L. Gillum - Middletown OH, US
Patrick A. Harrell - Loveland OH, US
David A. Parrott - Cincinnati OH, US
Sean E. Mackey - Grayslake IL, US
Rajkumar V. Conjeevaram - Lake bluff IL, US
Thomas Rebne - Woodstock GA, US
Bradley A. Clark - High Point NC, US
Jeremy L. Hemingway - Cincinnati OH, US
Ji Zhou - Grayslake IL, US
Bryan L. Wiesner - Lake Forest IL, US

International Classification:

A61M 5/315
B65B 1/04

US Classification:

604506, 604221, 53440

Abstract:

A syringe containing a high water content product and for use in a drug infusion system is provided. The syringe includes a plunger carrying front and rear o-rings made of a diene rubber compound such as chlorobutyl rubber or bromobutyl rubber to impart very low gas permeability characteristics to the o-rings. The plunger may be molded as a single part or in two parts. If molded as one part with radially-engaging mold portions, the seal glands in the plunger may include parting lines from the mold. If molded as two parts with axially-engaging mold portions, the front seal gland may include a sealing surface and under cut that has no parting line. The o-rings may be surface treated with a lubricant to improve sealing where the molding process gives rise to parting lines in the seal glands.

US Patent:

20230106081, Apr 6, 2023

Filed:

Oct 24, 2022

Appl. No.:

17/971836

Inventors:

- North Chicago IL, US
Vincent S. Chan - Evanston IL, US
Kassibla E. Dempah - Chicago IL, US
Brian P. Enright - Gurnee IL, US
Rodger F. Henry - Wildwood IL, US
Raimundo Ho - Chicago IL, US
Ye Huang - Gurnee IL, US
Alexander D. Huters - Chicago IL, US
Russell C. Klix - Buffalo Grove IL, US
Scott W. Krabbe - Lindenhurst IL, US
Philip R. Kym - Libertyville IL, US
Yanbin Lao - Lake Bluff IL, US
Xiaochun Lou - Long Grove IL, US
Sean E. Mackey - Grayslake IL, US
Mark A. Matulenko - Libertyville IL, US
Peter T. Mayer - Libertyville IL, US
Christopher P. Miller - Lake Forest IL, US
James Stambuli - Worcester MA, US
Valentino J. Stella - Lawrence KS, US
Eric A. Voight - Pleasant Prairie WI, US
Zhi Wang - Libertyville IL, US
Geoff G. Zhang - Vernon Hills IL, US

International Classification:

C07F 9/09
A61K 31/661
C07F 9/06
C07C 281/02
C07C 309/24
C07C 47/277
A61K 31/6615
A61K 45/06

Abstract:

The present disclosure relates to (a) carbidopa prodrugs, (b) pharmaceutical combinations and compositions comprising a carbidopa prodrug and/or an L-dopa prodrug, and (c) methods of treating Parkinson's disease and associated conditions comprising administering a carbidopa prodrug and an L-dopa prodrug to a subject with Parkinson's disease.

US Patent:

20210046029, Feb 18, 2021

Filed:

Mar 18, 2020

Appl. No.:

16/822892

Inventors:

- North Chicago IL, US
Alexandru DEAC - Skokie IL, US
Ye HUANG - Gurnee IL, US
Sean E. MACKEY - Grayslake IL, US
Randy A. MENGES - Lake Villa IL, US
Jayne ZIMMERMAN - Deerfield IL, US

International Classification:

A61K 31/198
A61K 9/00
A61K 9/10
A61K 47/38
A61K 47/32
A61K 47/10
A61K 45/06

Abstract:

The present disclosure relates to (a) an improved pharmaceutical composition comprising a levodopa active agent and a carbidopa active agent (b) methods of producing the pharmaceutical composition and (c) methods of treating Parkinson's disease and associated conditions comprising administering the pharmaceutical composition to a subject with Parkinson's disease.

US Patent:

20200276385, Sep 3, 2020

Filed:

Mar 12, 2020

Appl. No.:

16/816458

Inventors:

- North Chicago IL, US
Wayne Klinger - Lindenhurst IL, US
Thomas Paul Grazier - Spring Grove IL, US
Gurjinder Dhami - Neenah WI, US
Scott Smieja - Oshkosh WI, US
Jeff Schacherl - Neenah WI, US
Sean Mackey - Grayslake IL, US
Megan Feilen - Franklin WI, US
Ji Zhou - Lake Villa IL, US
Rajkumar Conjeevaram - Lake Bluff IL, US
Martin Gibler - West Chester OH, US

Assignee:

ABBVIE INC. - North Chicago IL

International Classification:

A61M 5/168
A61M 5/162
A61M 5/142

Abstract:

Drug delivery reservoir for delivery of a beneficial agent to a user includes a drug delivery reservoir housing having a fluid reservoir defined therein. The drug delivery reservoir housing has a drug delivery reservoir base region. The drug delivery reservoir includes a dip tube extending inside the fluid reservoir. The dip tube includes a tubular wall defining a flow lumen. The tubular wall has at least one aperture defined therein and spaced proximally from a distal end of the tubular wall in fluid communication with the fluid reservoir. The drug delivery reservoir includes an adaptor disposed external to the drug delivery reservoir housing and coupled to a proximal end of the dip tube.

US Patent:

20200262852, Aug 20, 2020

Filed:

May 4, 2020

Appl. No.:

16/866400

Inventors:

- North Chicago IL, US
Vincent S. Chan - Evanston IL, US
Kassibla E. Dempah - Chicago IL, US
Brian P. Enright - Gumee IL, US
Rodger F. Henry - Wildwood IL, US
Raimundo Ho - Chicago IL, US
Ye Huang - Gumee IL, US
Alexander D. Huters - Chicago IL, US
Russell C. Klix - Buffalo Grove IL, US
Scott W. Krabbe - Lindenhurst IL, US
Philip R. Kym - Libertyville IL, US
Yanbin Lao - Lake Bluff IL, US
Xiaochun Lou - Long Grove IL, US
Sean E. Mackey - Grayslake IL, US
Mark A. Matulenko - Libertyville IL, US
Peter T. Mayer - Libertyville IL, US
Christopher P. Miller - Lake Forest IL, US
James Stambuli - Buffalo Grove IL, US
Valentino J. Stella - Lawrence KS, US
Eric A. Voight - Pleasant Prairie WI, US
Zhi Wang - Libertyville IL, US
Geoff Zhang - Vernon Hills IL, US

International Classification:

C07F 9/09
A61K 45/06
A61K 31/6615
C07C 47/277
C07C 309/24
C07C 281/02
C07F 9/06
A61K 31/661

Abstract:

The present disclosure relates to (a) carbidopa prodrugs, (b) pharmaceutical combinations and compositions comprising a carbidopa prodrug and/or an L-dopa prodrug, and (c) methods of treating Parkinson's disease and associated conditions comprising administering a carbidopa prodrug and an L-dopa prodrug to a subject with Parkinson's disease.

US Patent:

20190375770, Dec 12, 2019

Filed:

Dec 5, 2018

Appl. No.:

16/210996

Inventors:

- North Chicago IL, US
Vincent S. Chan - Evanston IL, US
Kassibla E. Dempah - Chicago IL, US
Brian P. Enright - Gurnee IL, US
Rodger F. Henry - Wildwood IL, US
Raimundo Ho - Chicago IL, US
Ye Huang - Gurnee IL, US
Alexander D. Huters - Chicago IL, US
Russell C. Klix - Buffalo Grove IL, US
Scott W. Krabbe - Lindenhurst IL, US
Philip R. Kym - Libertyville IL, US
Yanbin Lao - Lake Bluff IL, US
Xiaochun Lou - Long Grove IL, US
Sean E. Mackey - Grayslake IL, US
Mark A. Matulenko - Libertyville IL, US
Peter T. Mayer - Libertyville IL, US
Christiopher P. Miller - Lake Forest IL, US
James Stambuli - Buffalo Grove IL, US
Valentino J. Stella - Lawrence KS, US
Eric A. Voight - Pleasant Prairie WI, US
Zhi Wang - Libertyville IL, US
Geoff G. Zhang - Vernon Hills IL, US

Assignee:

AbbVie Inc. - North Chicago IL

International Classification:

C07F 9/09
A61K 31/661
C07F 9/06
C07C 281/02
C07C 309/24
C07C 47/277
A61K 31/6615
A61K 45/06

Abstract:

The present disclosure relates to (a) carbidopa prodrugs, (b) pharmaceutical combinations and compositions comprising a carbidopa prodrug and/or an L-dopa prodrug, and (c) methods of treating Parkinson's disease and associated conditions comprising administering a carbidopa prodrug and an L-dopa prodrug to a subject with Parkinson's disease.

US Patent:

20190240416, Aug 8, 2019

Filed:

Feb 4, 2019

Appl. No.:

16/267318

Inventors:

- North Chicago IL, US
MARK A. BENNETT - LOVELAND OH, US
KENNETH R. WAEBER - MILFORD OH, US
KENNETH E. HOGUE - CHAPEL HILL NC, US
CHRISTOPH L. GILLUM - MIDDLETOWN OH, US
PATRICK A. HARRELL - LOVELAND OH, US
DAVID A. PARROTT - CINCINNATI OH, US
SEAN E. MACKEY - GRAYSLAKE IL, US
RAJKUMAR V. CONJEEVARAM - LAKE BLUFF IL, US
THOMAS REBNE - WOODSTOCK GA, US
BRADLEY A. CLARK - HIGH POINT NC, US
JEREMY L. HEMINGWAY - CINCINNATI OH, US
JI ZHOU - GRAYSLAKE IL, US

International Classification:

A61M 5/315
A61M 5/145
B65B 1/04

Abstract:

A syringe containing a high water content product and for use in a drug infusion system is provided. The syringe includes a plunger carrying front and rear o-rings made of a diene rubber compound such as chlorobutyl rubber or bromobutyl rubber to impart very low gas permeability characteristics to the o-rings. The plunger may be molded as a single part or in two parts. If molded as one part with radially-engaging mold portions, the seal glands in the plunger may include parting lines from the mold. If molded as two parts with axially-engaging mold portions, the front seal gland may include a sealing surface and under cut that has no parting line. The orings may be surface treated with a lubricant to improve sealing where the molding process gives rise to parting lines in the seal glands.

US Patent:

20190142777, May 16, 2019

Filed:

Oct 16, 2018

Appl. No.:

16/161940

Inventors:

- North Chicago IL, US
Alexandru DEAC - Skokie IL, US
Ye HUANG - Gurnee IL, US
Sean E. MACKEY - Grayslake IL, US
Randy A. MENGES - Lake Villa IL, US
Jayne Zimmerman - Deerfield IL, US

International Classification:

A61K 31/198
A61K 45/06
A61K 9/00
A61K 47/10
A61K 9/10
A61K 47/38
A61K 47/32

Abstract:

The present disclosure relates to (a) an improved pharmaceutical composition comprising a levodopa active agent and a carbidopa active agent (b) methods of producing the pharmaceutical composition and (c) methods of treating Parkinson's disease and associated conditions comprising administering the pharmaceutical composition to a subject with Parkinson's disease.