Sean P Mccarthy

US Patent:

20030022279, Jan 30, 2003

Filed:

Jan 12, 2001

Appl. No.:

09/759130

Inventors:

Christopher Fraser - Lexington MA, US
Thomas Barnes - Brookline MA, US
John Sharp - Arlington MA, US
Susan Kirst - Brookline MA, US
Paul Myers - Cambridge MA, US
Kevin Leiby - Natick MA, US
Douglas Holtzman - Jamaica Plain MA, US
Sean McCarthy - San Diego CA, US
Nicholas Wrighton - Winchester MA, US
Charles MacKay - Vaucluse, AU
Andrew Goodearl - Natick MA, US

International Classification:

A01K067/00
C07H021/04
C12P021/02
C12N005/06
C07K014/435

US Classification:

435/069100, 435/320100, 435/325000, 514/044000, 530/350000, 536/023200, 800/008000

Abstract:

The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.

US Patent:

20040121396, Jun 24, 2004

Filed:

Dec 19, 2003

Appl. No.:

10/741790

Inventors:

Christopher Fraser - Lexington MA, US
Thomas Barnes - Brookline MA, US
John Sharp - Arlington MA, US
Susan Kirst - Brookline MA, US
Paul Myers - Cambridge MA, US
Kevin Leiby - Natick MA, US
Douglas Holtzman - Jamaica Plain MA, US
Sean McCarthy - San Diego CA, US
Nicholas Wrighton - Winchester MA, US
Charles MacKay - Vaucluse, AU
Andrew Goodearl - Natick MA, US

Assignee:

Millennium Pharmaceuticals, Inc.

International Classification:

C12Q001/68
A01K067/00
C07H021/04
C07K014/47

US Classification:

435/006000, 435/069100, 435/320100, 435/325000, 530/350000, 536/023200, 800/008000, 530/388100

Abstract:

The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.

US Patent:

20060205034, Sep 14, 2006

Filed:

Nov 2, 2005

Appl. No.:

11/265762

Inventors:

Christopher Fraser - Lexington MA, US
Sean McCarthy - San Diego CA, US
John Sharp - Arlington MA, US
Thomas Barnes - Brookline MA, US
Nicholas Wrighton - Winchester MA, US
Charles Mackay - Vaucluse, AU
Kevin Leiby - San Francisco CA, US
Douglas Holtzman - Seattle WA, US

International Classification:

C07K 14/715
C07H 21/04
C12P 21/06
C07K 16/28

US Classification:

435069100, 435320100, 435325000, 530350000, 530388220, 536023500

Abstract:

The invention provides isolated nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

US Patent:

20090220977, Sep 3, 2009

Filed:

Jan 9, 2009

Appl. No.:

12/319689

Inventors:

Christopher C. Fraser - Lexington MA, US
Sean Anthony McCarthy - San Diego CA, US
John D. Sharp - Arlington MA, US
Thomas M. Barnes - Brookline MA, US
Nicholas C. Wrighton - Winchester MA, US
Charles R. Mackay - Vaucluse, AU
Kevin R. Leiby - San Francisco CA, US
Douglas A. Holtzman - Seattle WA, US

International Classification:

C12Q 1/68
G01N 33/53
C12N 5/10
C12N 15/63
C07K 14/435
C07K 16/00
C07H 21/04

US Classification:

435 6, 435 71, 435325, 4353201, 530350, 5303879, 536 235

Abstract:

The invention provides isolated nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

US Patent:

20100062487, Mar 11, 2010

Filed:

May 8, 2009

Appl. No.:

12/387959

Inventors:

Christopher C. Fraser - Lexington MA, US
Thomas M. Barnes - Brookline MA, US
John D. Sharp - Arlington MA, US
Susan J. Kirst - Brookline MA, US
Paul S. Myers - Cambridge MA, US
Kevin R. Leiby - Natick MA, US
Douglas A. Holtzman - Jamaica Plain MA, US
Sean A. McCarthy - San Diego CA, US
Nicholas Wrighton - Winchester MA, US
Charles R. Mackay - Vaucluse, AU
Andrew D.J. Goodearl - Natick MA, US

International Classification:

C12P 21/02
C07H 21/04
C12N 5/00
C12N 1/00
C07K 14/00
C07K 16/00
G01N 33/53

US Classification:

435 691, 536 231, 435325, 435243, 530350, 5303871, 436 86, 436 94, 536 243

Abstract:

The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.

US Patent:

20100291579, Nov 18, 2010

Filed:

Jul 1, 2010

Appl. No.:

12/803671

Inventors:

Christopher C. Fraser - Lexington MA, US
Sean Anthony McCarthy - San Diego CA, US
John D. Sharp - Arlington MA, US
Thomas M. Barnes - Brookline MA, US
Nicholas C. Wrighton - Winchester MA, US
Charles R. Mackay - Vaucluse, AU
Kevin R. Leiby - San Francisco CA, US
Douglas A. Holtzman - Seattle WA, US

International Classification:

C12Q 1/68
G01N 33/53
C12P 21/06
C12N 5/10
C12N 5/02
C12N 15/63
C07K 14/435
C07K 16/18
C07K 1/00
C07H 21/04

US Classification:

435 6, 435 71, 435 691, 435325, 435375, 4353201, 530350, 5303879, 530402, 536 235

Abstract:

The invention provides isolated nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

US Patent:

20120045777, Feb 23, 2012

Filed:

Jun 27, 2011

Appl. No.:

13/169686

Inventors:

Christopher C. Fraser - Lexington MA, US
Thomas M. Barnes - Brookline MA, US
John D. Sharp - Arlington MA, US
Susan J. Kirst - Brookline MA, US
Paul S. Myers - Cambridge MA, US
Kevin R. Leiby - Natick MA, US
Douglas A. Holtzman - Jamaica Plain MA, US
Sean A. McCarthy - San Diego CA, US
Nicholas Wrighton - Winchester MA, US
Charles R. Mackay - Vaucluse, AU
Andrew D.J. Goodearl - Natick MA, US

Assignee:

Millennium Pharmaceuticals, Inc. - Cambridge MA

International Classification:

G01N 33/53
C12Q 1/37
C12P 21/02
C12N 9/99
C12N 9/64
C12N 15/57
C12N 5/00
C12N 15/63
G01N 33/50
C07K 14/00
C07K 16/18
C07H 21/04
G01N 33/573
C12N 5/10

US Classification:

435 721, 435 74, 435 792, 435 23, 435 691, 435184, 435226, 435325, 435375, 4353201, 436501, 436 94, 530350, 5303879, 536 231, 536 232

Abstract:

The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.