Sean P Mccarthy

US Patent:

20030022279, Jan 30, 2003

Filed:

Jan 12, 2001

Appl. No.:

09/759130

Inventors:

Christopher Fraser - Lexington MA, US
Thomas Barnes - Brookline MA, US
John Sharp - Arlington MA, US
Susan Kirst - Brookline MA, US
Paul Myers - Cambridge MA, US
Kevin Leiby - Natick MA, US
Douglas Holtzman - Jamaica Plain MA, US
Sean McCarthy - San Diego CA, US
Nicholas Wrighton - Winchester MA, US
Charles MacKay - Vaucluse, AU
Andrew Goodearl - Natick MA, US

International Classification:

A01K067/00
C07H021/04
C12P021/02
C12N005/06
C07K014/435

US Classification:

435/069100, 435/320100, 435/325000, 514/044000, 530/350000, 536/023200, 800/008000

Abstract:

The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.

US Patent:

20030069196, Apr 10, 2003

Filed:

Dec 4, 2001

Appl. No.:

10/004633

Inventors:

Douglas Levinson - Sherborn MA, US
Clare Lloyd - London, GB
Sean McCarthy - San Diego CA, US

Assignee:

Millennium Pharmaceuticals, Inc.

International Classification:

A61K048/00
C07H021/04

US Classification:

514/044000, 536/023200

Abstract:

The present invention relates to methods and compositions for the treatment and diagnosis of immune disorders, especially T helper lymphocyte-related disorders, and also for the treatment of mast cell-related processes and disorders, ischemic disorders and injuries, including ischemic renal disorders and injuries. For example, genes which are differentially expressed within and among T helper (TH) cells and TH cell subpopulations, which include, but are not limited to TH0, TH1 and TH2 cell subpopulations are identified. Genes are also identified via the ability of their gene products to interact with gene products involved in the differentiation, maintenance and effector function of such TH cells and TH cell subpopulations. The genes identified can be used diagnostically or as targets for therapeutic intervention. In this regard, the present invention provides methods for the identification and therapeutic use of compounds as treatments of immune disorders, especially TH cell subpopulation-related disorders. Additionally, methods are provided for the diagnostic evaluation and prognosis of TH cell subpopulation-related disorders, for the identification of subjects exhibiting a predisposition to such conditions, for monitoring patients undergoing clinical evaluation for the treatment of such disorders, and for monitoring the efficacy of compounds used in clinical trials. Methods are also provided for the treatment of symptoms associated with mast cell-related processes or disorders and ischemic disorders and injuries using the genes, gene products and antibodies of the invention.

US Patent:

20040121396, Jun 24, 2004

Filed:

Dec 19, 2003

Appl. No.:

10/741790

Inventors:

Christopher Fraser - Lexington MA, US
Thomas Barnes - Brookline MA, US
John Sharp - Arlington MA, US
Susan Kirst - Brookline MA, US
Paul Myers - Cambridge MA, US
Kevin Leiby - Natick MA, US
Douglas Holtzman - Jamaica Plain MA, US
Sean McCarthy - San Diego CA, US
Nicholas Wrighton - Winchester MA, US
Charles MacKay - Vaucluse, AU
Andrew Goodearl - Natick MA, US

Assignee:

Millennium Pharmaceuticals, Inc.

International Classification:

C12Q001/68
A01K067/00
C07H021/04
C07K014/47

US Classification:

435/006000, 435/069100, 435/320100, 435/325000, 530/350000, 536/023200, 800/008000, 530/388100

Abstract:

The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.

US Patent:

20050119209, Jun 2, 2005

Filed:

May 3, 2004

Appl. No.:

10/838852

Inventors:

Douglas Levinson - Sherborn MA, US
Clare Lloyd - London, GB
Sean McCarthy - Boston MA, US

International Classification:

A61K048/00
C07H021/04

US Classification:

514044000, 536023200

Abstract:

The present invention relates to methods and compositions for the treatment and diagnosis of immune disorders, especially T helper lymphocyte-related disorders, and also for the treatment of mast cell-related processes and disorders, ischemic disorders and injuries, including ischemic renal disorders and injuries. For example, genes which are differentially expressed within and among T helper (TH) cells and TH cell subpopulations, which include, but are not limited to TH0, TH1 and TH2 cell subpopulations are identified. Genes are also identified via the ability of their gene products to interact with gene products involved in the differentiation, maintenance and effector function of such TH cells and TH cell subpopulations. The genes identified can be used diagnostically or as targets for therapeutic intervention. In this regard, the present invention provides methods for the identification and therapeutic use of compounds as treatments of immune disorders, especially TH cell subpopulation-related disorders. Additionally, methods are provided for the diagnostic evaluation and prognosis of TH cell subpopulation-related disorders, for the identification of subjects exhibiting a predisposition to such conditions, for monitoring patients undergoing clinical evaluation for the treatment of such disorders, and for monitoring the efficacy of compounds used in clinical trials. Methods are also provided for the treatment of symptoms associated with mast cell-related processes or disorders and ischemic disorders and injuries using the genes, gene products and antibodies of the invention.

US Patent:

20060205034, Sep 14, 2006

Filed:

Nov 2, 2005

Appl. No.:

11/265762

Inventors:

Christopher Fraser - Lexington MA, US
Sean McCarthy - San Diego CA, US
John Sharp - Arlington MA, US
Thomas Barnes - Brookline MA, US
Nicholas Wrighton - Winchester MA, US
Charles Mackay - Vaucluse, AU
Kevin Leiby - San Francisco CA, US
Douglas Holtzman - Seattle WA, US

International Classification:

C07K 14/715
C07H 21/04
C12P 21/06
C07K 16/28

US Classification:

435069100, 435320100, 435325000, 530350000, 530388220, 536023500

Abstract:

The invention provides isolated nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

US Patent:

20090041752, Feb 12, 2009

Filed:

Jul 31, 2007

Appl. No.:

11/888354

Inventors:

Douglas Adam Levinson - Sherborn MA, US
Clare M. Lloyd - London, GB
Sean A. McCarthy - San Diego CA, US

International Classification:

A61K 39/395
A61K 38/00
A61P 9/00

US Classification:

4241301, 514 2, 514 12

Abstract:

The present invention relates to methods and compositions for the treatment and diagnosis of immune disorders, especially T helper lymphocyte-related disorders, and also for the treatment of mast cell-related processes and disorders, ischemic disorders and injuries, including ischemic renal disorders and injuries. For example, genes which are differentially expressed within and among T helper (TH) cells and TH cell subpopulations, which include, but are not limited to TH0, TH1 and TH2 cell subpopulations are identified. Genes are also identified via the ability of their gene products to interact with gene products involved in the differentiation, maintenance and effector function of such TH cells and TH cell subpopulations. The genes identified can be used diagnostically or as targets for therapeutic intervention. In this regard, the present invention provides methods for the identification and therapeutic use of compounds as treatments of immune disorders, especially TH cell subpopulation-related disorders. Additionally, methods are provided for the diagnostic evaluation and prognosis of TH cell subpopulation-related disorders, for the identification of subjects exhibiting a predisposition to such conditions, for monitoring patients undergoing clinical evaluation for the treatment of such disorders, and for monitoring the efficacy of compounds used in clinical trials. Methods are also provided for the treatment of symptoms associated with mast cell-related processes or disorders and ischemic disorders and injuries using the genes, gene products and antibodies of the invention.

US Patent:

20090220977, Sep 3, 2009

Filed:

Jan 9, 2009

Appl. No.:

12/319689

Inventors:

Christopher C. Fraser - Lexington MA, US
Sean Anthony McCarthy - San Diego CA, US
John D. Sharp - Arlington MA, US
Thomas M. Barnes - Brookline MA, US
Nicholas C. Wrighton - Winchester MA, US
Charles R. Mackay - Vaucluse, AU
Kevin R. Leiby - San Francisco CA, US
Douglas A. Holtzman - Seattle WA, US

International Classification:

C12Q 1/68
G01N 33/53
C12N 5/10
C12N 15/63
C07K 14/435
C07K 16/00
C07H 21/04

US Classification:

435 6, 435 71, 435325, 4353201, 530350, 5303879, 536 235

Abstract:

The invention provides isolated nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

US Patent:

20100062487, Mar 11, 2010

Filed:

May 8, 2009

Appl. No.:

12/387959

Inventors:

Christopher C. Fraser - Lexington MA, US
Thomas M. Barnes - Brookline MA, US
John D. Sharp - Arlington MA, US
Susan J. Kirst - Brookline MA, US
Paul S. Myers - Cambridge MA, US
Kevin R. Leiby - Natick MA, US
Douglas A. Holtzman - Jamaica Plain MA, US
Sean A. McCarthy - San Diego CA, US
Nicholas Wrighton - Winchester MA, US
Charles R. Mackay - Vaucluse, AU
Andrew D.J. Goodearl - Natick MA, US

International Classification:

C12P 21/02
C07H 21/04
C12N 5/00
C12N 1/00
C07K 14/00
C07K 16/00
G01N 33/53

US Classification:

435 691, 536 231, 435325, 435243, 530350, 5303871, 436 86, 436 94, 536 243

Abstract:

The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.