Sean T Mccarthy

US Patent:

7057017, Jun 6, 2006

Filed:

Oct 4, 2001

Appl. No.:

09/972473

Inventors:

Sean A. McCarthy - San Diego CA, US

Assignee:

Millennium Pharmaceuticals, Inc. - Cambridge MA

International Classification:

C07K 14/47
C07K 14/475
C07K 19/00

US Classification:

530350, 530300, 530324, 530866

Abstract:

Novel Dkk and Dkk-related polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length Dkk and Dkk-related proteins, the invention further provides isolated fusion proteins, antigenic peptides and antibodies. The invention also provides Dkk and Dkk-related nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a Dkk and Dkk-related gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

US Patent:

7446181, Nov 4, 2008

Filed:

Apr 6, 2004

Appl. No.:

10/819054

Inventors:

Sean A. McCarthy - San Diego CA, US

Assignee:

Millennium Pharmaceuticals, Inc. - Cambridge MA

International Classification:

C07K 16/24

US Classification:

53038823, 5303873, 5303881, 53038815, 5303891, 5303892, 5303913, 530866

Abstract:

The invention relates to antibodies and immunologically active portions thereof that selectively bind a human Dickkopf-1 (Dkk-1) or Dkk-1-related polypeptide, and to compositions that contain such antibodies and/or immunologically active portions.

US Patent:

7579168, Aug 25, 2009

Filed:

Oct 21, 2005

Appl. No.:

11/255790

Inventors:

Sean A McCarthy - San Diego CA, US

Assignee:

Millennium Pharmaceuticals, Inc. - Cambridge MA

International Classification:

C12P 21/02
C12N 15/63
C12N 15/74
C12N 15/79
C12N 15/81
C12N 15/86
C12N 1/21
C12N 1/19
C12N 5/10
C12N 15/12
C12N 15/62
C07H 21/04
C07K 14/47
C07K 19/00

US Classification:

435 691, 4352523, 4352542, 4353201, 435325, 435348, 530350, 536 234, 536 235, 536 241

Abstract:

Novel Dkk and Dkk-related polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length Dkk and Dkk-related proteins, the invention further provides isolated fusion proteins, antigenic peptides and antibodies. The invention also provides Dkk and Dkk-related nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a Dkk and Dkk-related gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

US Patent:

7645451, Jan 12, 2010

Filed:

Feb 28, 2005

Appl. No.:

11/069137

Inventors:

Sean A. McCarthy - San Diego CA, US

Assignee:

Millennium Pharmaceuticals, Inc. - Cambridge MA

International Classification:

A61K 39/395
C07K 16/18
C07K 16/46

US Classification:

4241421, 424 149, 4241331, 4241781, 5303873, 53038815, 530866, 530867

Abstract:

Novel Dkk and Dkk-related polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length Dkk and Dkk-related proteins, the invention further provides isolated fusion proteins, antigenic peptides and antibodies. The invention also provides Dkk and Dkk-related nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and n which a Dkk and Dkk-related gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

US Patent:

7897725, Mar 1, 2011

Filed:

Oct 12, 2007

Appl. No.:

11/974478

Inventors:

Sean A. McCarthy - San Diego CA, US
David P. Gearing - Camberwell, AU

International Classification:

C07K 1/00
C07H 21/04
C12N 15/85
C12N 15/63

US Classification:

530350, 435326, 4353201, 4352523, 43525411, 536 235

Abstract:

The invention provides novel Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 polypeptides, proteins, and nucleic acid molecules. In addition to isolated, full-length Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 proteins, the invention further provides isolated Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 fusion proteins, antigenic peptides and anti-Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 antibodies. The invention also provides Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 or A259 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

US Patent:

8202966, Jun 19, 2012

Filed:

Nov 12, 2009

Appl. No.:

12/616901

Inventors:

Sean A. McCarthy - San Diego CA, US

Assignee:

Millennium Pharmaceuticals, Inc. - Cambridge MA

International Classification:

C07K 14/475
C07K 19/00
G01N 33/53

US Classification:

530300, 530350, 435 72

Abstract:

Novel Dkk and Dkk-related polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length Dkk and Dkk-related proteins, the invention further provides isolated fusion proteins, antigenic peptides and antibodies. The invention also provides Dkk and Dkk-related nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a Dkk and Dkk-related gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

US Patent:

8571899, Oct 29, 2013

Filed:

Jul 20, 2012

Appl. No.:

13/554935

Inventors:

Robert Phillips Cochran - New York NY, US
Sean Wallace McCarthy - New York NY, US

Assignee:

HG Global Ltd. - Hamilton HM

International Classification:

G06Q 30/00

US Classification:

705 4

Abstract:

A computer includes a processor and a memory storing data and executable instructions to operate a municipal financial guaranty mutual insurance company. The processor processes the data and executable instructions to track insurance premiums paid by members of the municipal financial guaranty mutual insurance company, monitor private investment capital into a holding firm, follow the investment of a first subset of the private investment capital of the holding firm into the municipal financial guaranty mutual insurance company in exchange for first promissory notes, track a second subset of the private investment capital of the holding firm into a reinsurance firm, follow the investment of a segment of the second subset of the private investment capital of the reinsurance firm into the municipal financial guaranty mutual insurance company in exchange for second promissory notes, and manage reinsurance firm first loss claims from the municipal financial guaranty mutual insurance company.

US Patent:

20020028508, Mar 7, 2002

Filed:

Feb 21, 2001

Appl. No.:

09/790264

Inventors:

Douglas Holtzman - Jamaica Plain MA, US
Andrew Goodearl - Natick MA, US
Sean McCarthy - San Diego CA, US

International Classification:

G01N033/53
C07H021/02
C07H021/04
C12P021/06
C12N001/20
C12N005/00
C12N005/02
C07K001/00
C07K014/00
C07K017/00
C07K016/00

US Classification:

435/325000, 536/023100, 435/252300, 530/350000, 530/387100, 435/007100, 435/068100

Abstract:

The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.