Sean C Morrison

US Patent:

7850961, Dec 14, 2010

Filed:

Sep 29, 2006

Appl. No.:

11/529869

Inventors:

Michael F. Clarke - Palo Alto CA, US
Sean J. Morrison - Ann Arbor MI, US
Max S. Wicha - Ann Arbor MI, US
Muhammad Al-Hajj - La Jolla CA, US

Assignee:

The Regents of The University of Michigan - Ann Arbor MI

International Classification:

A61K 39/395
C07K 16/28
C07K 16/30

US Classification:

4241301, 4241431, 4241781, 5303871, 53038822, 5303888, 5303897

Abstract:

A small percentage of cells within an established solid tumor have the properties of stem cells. These solid tumor stem cells give rise both to more tumor stem cells and to the majority of cells in the tumor that have lost the capacity for extensive proliferation and the ability to give rise to new tumors. Thus, solid tumor heterogeneity reflects the presence of tumor cell progeny arising from a solid tumor stem cell. We have developed a xenograft model in which we have been able to establish tumors from primary tumors via injection of tumors in the mammary gland of severely immunodeficient mice. These xenograft assay have allowed us to do biological and molecular assays to characterize clonogenic solid tumor stem cells. We have also developed evidence that strongly implicates the Notch pathway, especially Notch 4, as playing a central pathway in carcinogenesis.

US Patent:

8357491, Jan 22, 2013

Filed:

Dec 28, 2010

Appl. No.:

12/979991

Inventors:

Michael F. Clarke - Palo Alto CA, US
Sean J. Morrison - Ann Arbor MI, US
Max S. Wicha - Ann Arbor MI, US
Muhammad Al-Hajj - Eagleville PA, US

Assignee:

The Regents of the University of Michigan - Ann Arbor MI

International Classification:

C12Q 1/68
C12P 19/34

US Classification:

435 612, 435 912

Abstract:

A small percentage of cells within an established solid tumor have the properties of stem cells. These solid tumor stem cells give rise to both more tumor stem cells and to the majority of cells in the tumor that have lost the capacity for extensive proliferation and the ability to give rise to new tumors. Thus, solid tumor heterogeneity reflects the presence of tumor cell progeny arising from a solid tumor stem cell. We have developed a xenograft model in which we have been able to establish tumors from primary tumors via injection of tumors in the mammary gland of severely immunodeficient mice. These xenograft assay have allowed us to do biological and molecular assays to characterize clonogenic solid tumor stem cells. We have also developed evidence that strongly implicates the Notch pathway, especially Notch 4, as playing a central pathway in carcinogenesis.

US Patent:

20080194022, Aug 14, 2008

Filed:

Apr 20, 2007

Appl. No.:

11/788489

Inventors:

Michael F. Clarke - Palo Alto CA, US
Sean J. Morrison - Ann Arbor MI, US
Max S. Wicha - Ann Arbor MI, US
Muhammad Al-Hajj - La Jolla CA, US

International Classification:

C12N 5/06

US Classification:

435377, 435375

Abstract:

A small percentage of cells within an established solid tumor have the properties of stem cells. These solid tumor stem cells give rise both to more tumor stem cells and to the majority of cells in the tumor that have lost the capacity for extensive proliferation and the ability to give rise to new tumors. Thus, solid tumor heterogeneity reflects the presence of tumor cell progeny arising from a solid tumor stem cell.We have developed a xenograft model in which we have been able to establish tumors from primary tumors via injection of tumors in the mammary gland of severely immunodeficient mice. These xenograft assay have allowed us to do biological and molecular assays to characterize clonogenic solid tumor stem cells.We have also developed evidence that strongly implicates the Notch pathway, especially Notch 4, as playing a central pathway in carcinogenesis.

US Patent:

20140011274, Jan 9, 2014

Filed:

Dec 14, 2012

Appl. No.:

13/714921

Inventors:

Michael F. Clarke - Palo Alto CA, US
Sean J. Morrison - Ann Arbor MI, US
Max S. Wicha - Ann Arbor MI, US
Muhammad Al-Hajj - Eagleville MI, US

Assignee:

The Regents of the University of Michigan - Ann Arbor MI

International Classification:

C12N 5/09

US Classification:

435366

Abstract:

A small percentage of cells within an established solid tumor have the properties of stem cells. These solid tumor stem cells give rise to both more tumor stem cells and to the majority of cells in the tumor that have lost the capacity for extensive proliferation and the ability to give rise to new tumors. Thus, solid tumor heterogeneity reflects the presence of tumor cell progeny arising from a solid tumor stem cell.We have developed a xenograft model in which we have been able to establish tumors from primary tumors via injection of tumors in the mammary gland of severely immunodeficient mice. These xenograft assay have allowed us to do biological and molecular assays to characterize clonogenic solid tumor stem cells.We have also developed evidence that strongly implicates the Notch pathway, especially Notch 4, as playing a central pathway in carcinogenesis.