Sean W O'Malley

US Patent:

7130873, Oct 31, 2006

Filed:

Jun 2, 2003

Appl. No.:

10/452795

Inventors:

Steven R. Kleiman - Los Altos CA, US
David Hitz - Los Altos CA, US
Norman Hutchinson - Richmond, CA
Sean O'Malley - Tucson AZ, US

Assignee:

Network Appliance Inc. - Sunnyvale CA

International Classification:

G06F 12/00
G06F 17/30

US Classification:

707203, 707204

Abstract:

The invention provides techniques for duplicating all or part of a file system while maintaining consistent copies of the file system. A preferred embodiment reads data from the source file system (mapped according to a first storage block arrangement) creates an image stream and writes this data onto the destination file system (in accordance with a second storage block arrangement). Thus, the invention allows an image transfer between file systems that have dissimilar characteristics. An intermediate storage medium can be used to store or transmit the data read from the source file system before writing the data to the destination file system. (For example, the intermediate storage medium can include a magnetic tape or other archival device, or a network. ) Another aspect of the invention writes the data to the intermediate storage medium using a normalized or implied block list. The information is read from the intermediate storage medium using normalized or implied block list and written to the destination file system according to the second storage block arrangement.

US Patent:

7145025, Dec 5, 2006

Filed:

Jul 29, 2003

Appl. No.:

10/629538

Inventors:

Samuel Fournier Lockwood - Lago Vista TX, US
Sean O'Malley - Honolulu HI, US
David G. Watumull - Honolulu HI, US
Laura M. Hix - Honolulu HI, US
Henry Jackson - Honolulu HI, US
Geoff Nadolski - Kaaawa HI, US

Assignee:

Hawaii Biotech, Inc. - Aiea HI

International Classification:

A61K 31/341

US Classification:

549473

Abstract:

A method for inhibiting and/or ameliorating the occurrence of diseases associated with reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals in a subject whereby a subject is administered a carotenoid structural analog, either alone or in combination with another carotenoid analog, or co-antioxidant formulation. The analog or analog combination is administered such that the subject's risk of experiencing diseases associated with reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals may be thereby reduced. The analog or analog combination may be administered to a subject for the inhibition and/or amelioration of ischemia-reperfusion injury, liver disease, cancer, cardiac arrhythmia and/or sudden cardiac death, and/or any disease that involves production of reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals. In one embodiment, a water-soluble and/or water-dispersible astaxanthin analog is particularly effective. This invention further includes pharmaceutical compositions comprising structural carotenoid analogs either alone or in combination.

US Patent:

7174352, Feb 6, 2007

Filed:

May 10, 2001

Appl. No.:

09/854187

Inventors:

Steven R. Kleiman - Los Altos CA, US
David Hitz - Los Altos CA, US
Guy Harris - Mountain View CA, US
Sean W. O'Malley - Tucson AZ, US
Michael Malcolm - Los Altos CA, US
James Lau - Los Altos Hills CA, US
Byron Rakitzis - Burlingame CA, US

Assignee:

Network Appliance, Inc. - Sunnyvale CA

International Classification:

G06F 17/00

US Classification:

707203, 707204

Abstract:

The invention provides a method and system for duplicating all or part of a file system while maintaining consistent copies of the file system. The file server maintains a set of snapshots, each indicating a set of storage blocks making up a consistent copy of the file system as it was at a known time. Each snapshot can be used for a purpose other than maintaining the coherency of the file system, such as duplicating or transferring a backup copy of the file system to a destination storage medium. In a preferred embodiment, the snapshots can be manipulated to identify sets of storage blocks in the file system for incremental backup or copying, or to provide a file system backup that is both complete and relatively inexpensive. Also in a preferred embodiment, shadow snapshots can be maintained, with a shadow snapshot including a set of member storage blocks that formed a consistent file system other than an active file system, with a set of selected member storage blocks removed from the consistent file system.

US Patent:

7592449, Sep 22, 2009

Filed:

Feb 17, 2006

Appl. No.:

11/357897

Inventors:

Samuel Fournier Lockwood - Lago Vista TX, US
Sean O'Malley - Honolulu HI, US
David G. Watumull - Honolulu HI, US
Laura M. Hix - Honolulu HI, US
Henry Jackson - Honolulu HI, US
Geoff Nadolski - Kaaawa HI, US

Assignee:

Cardax Pharmaceuticals, Inc. - Aiea HI

International Classification:

C07D 233/12
C07D 265/30
C07D 473/00

US Classification:

544106, 544264, 5483511, 549315, 549415

Abstract:

A method for inhibiting and/or ameliorating the occurrence of diseases associated with reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals in a subject whereby a subject is administered a carotenoid structural analog, either alone or in combination with another carotenoid analog, or co-antioxidant formulation. The analog or analog combination is administered such that the subject's risk of experiencing diseases associated with reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals may be thereby reduced. The analog or analog combination may be administered to a subject for the inhibition and/or amelioration of ischemia-reperfusion injury. The analog or analog combination may be administered to a subject for the inhibition and/or amelioration of liver disease. The analog or analog combination may be administered to a subject for the inhibition and/or amelioration of cancer.

US Patent:

7691901, Apr 6, 2010

Filed:

Apr 14, 2005

Appl. No.:

11/106378

Inventors:

Samuel Fournier Lockwood - Lago Vista TX, US
Sean O'Malley - Honolulu HI, US
Henry Jackson - Honolulu HI, US
Geoff Nadolski - Kaneohe HI, US

Assignee:

Cardax Pharmaceuticals Inc. - Aiea HI

International Classification:

A61K 31/341
A61K 31/351

US Classification:

514460, 514473

Abstract:

A method for inhibiting and/or ameliorating the occurrence of diseases in a human subject whereby a subject is administered a carotenoid analog or derivative, either alone or in combination with another carotenoid analog or derivative. In some embodiments, the administration of analogs or derivatives of carotenoids may inhibit and/or ameliorate the occurrence of diseases in subjects. In some embodiments, analogs or derivatives of carotenoids may be water-soluble and/or water dispersible. Maladies that may be treated with analogs or derivatives of carotenoids embodied herein may include diseases that provoke or trigger an inflammatory response. In an embodiment, asthma may be treated with analogs or derivatives of carotenoids embodied herein. In an embodiment, administering analogs or derivatives of carotenoids embodied herein to a subject may control or affect the bioavailability of eicosanoids. In an embodiment, atherosclerosis may be treated with analogs or derivatives of carotenoids embodied herein.

US Patent:

20010044807, Nov 22, 2001

Filed:

Jul 31, 1998

Appl. No.:

09/127497

Inventors:

STEVEN KLEIMAN - LOS ALTOS CA, US
DAVID HITZ - PORTOLA VALLEY CA, US
GUY HARRIS - MOUNTAIN VIEW CA, US
SEAN O'MALLEY - SANTA CLARA CA, US

International Classification:

G06F017/30

US Classification:

707/203000, 707/100000, 707/204000

Abstract:

The invention provides a method and system for duplicating all or part of a file system while maintaining consistent copies of the file system. The file server maintains a set of snapshots, each indicating a set of storage blocks making up a consistent copy of the file system as it was at a known time. Each snapshot can be used for a purpose other than maintaining the coherency of the file system, such as duplicating or transferring a backup copy of the file system to a destination storage medium. In a preferred embodiment, the snapshots can be manipulated to identify sets of storage blocks in the file system for incremental backup or copying, or to provide a file system backup that is both complete and relatively inexpensive.

US Patent:

20050216384, Sep 29, 2005

Filed:

Dec 15, 2003

Appl. No.:

10/736058

Inventors:

Daniel Partlow - Westport CT, US
Kam Haq - New York NY, US
Maria Mejevitch - Westport CT, US
Sean O'Malley - New York NY, US

International Classification:

G06F017/60

US Classification:

705035000

Abstract:

A system, method and computer program for creating and valuing financial instruments (including but not limited to futures, forwards, call options, put options, swaps, “swaptions”, and “op-swaps”) linked to published real estate indices. The present invention will be referred to in this application as a real estate index linked financial instrument, and is defined as a financial instrument whose value changes based on movements in underlying indices based on real estate prices. These indices are published by sovereign governments, government-chartered agencies and departments (such as Fannie Mae, Freddie Mac, Office of Management and Budget, and the Treasury Department in the U.S.), non-governmental organizations, commercial banks, investment banks, realty agencies and many other organizations. The instruments can be written, with a published index number from any real estate index or indices as the initial value upon which the financial instrument's terms are based. The predicted future value of the real estate index or indices will change in response to market buy/sell demand based on investor expectations of the predicted future value of the real estate index or indices related to one or more real estate index linked financial instrument(s). Thus, the predicted future value of the index or indices will change in response to the market demand as investors offer to buy and/or sell real estate index linked financial instruments which will be listed on securities exchanges and electronic commerce networks (ECNs) as well as over the counter (OTC) and in private transactions. Each predicted future index value will change based on the investor expectation of how strong demand will be for the underlying real estate market upon which each index or indices are based. Thus, the present invention gives investors a means of taking or adjusting positions upon price movements in local, city, regional, state, national, or multinational/international real estate markets. It is important to note that real estate index linked financial instruments can be created either in standardized contract sizes that can be traded on futures, options or other securities exchanges, ECNs and/or OTC, or can be customized to meet the specifications of a transactional counterparty which wishes to speculate on movements in local, city, regional, state, national, or multinational/international real estate prices. Such instruments may also be created from a plurality of indices, thus allowing an investor to package movements from several different real estate indices into a single financial instrument. Such instruments may also involve a combination of real estate index linked financial instruments, either with each other or with other financial instruments in a combination containing at least one real estate index linked financial instrument.

US Patent:

20060058269, Mar 16, 2006

Filed:

Aug 29, 2005

Appl. No.:

11/214478

Inventors:

Samuel Lockwood - Lago Vista TX, US
Sean O'Malley - Honolulu HI, US
Henry Jackson - Honolulu HI, US
Geoff Nadolski - Kaneohe HI, US

International Classification:

A61K 31/66
A61K 31/015

US Classification:

514124000, 514763000

Abstract:

A method for inhibiting and/or ameliorating the occurrence of diseases in a human subject whereby a subject is administered a carotenoid analog or derivative, either alone or in combination with another carotenoid analog or derivative. In some embodiments, the administration of analogs or derivatives of carotenoids may inhibit and/or ameliorate the occurrence of diseases in subjects. In some embodiments, analogs or derivatives of carotenoids may be water-soluble and/or water dispersible. Maladies that may be treated with analogs or derivatives of carotenoids embodied herein may include diseases that provoke or trigger an inflammatory response. In an embodiment, asthma may be treated with analogs or derivatives of carotenoids embodied herein. In an embodiment, administering analogs or derivatives of carotenoids embodied herein to a subject may control or affect the bioavailability of eicosanoids. In an embodiment, atherosclerosis may be treated with analogs or derivatives of carotenoids embodied herein. In an embodiment, administering the analogs or derivatives of carotenoids embodied herein to a subject may control or affect the bioavailability of 5-LO-catalyzed eicosanoid metabolites. In an embodiment, 5-LO-catalyzed eicosanoid metabolites that may be controlled or affected by administering analogs or derivatives of carotenoids to a subject may include proinflammatory effector molecules (e.g., leukotrienes).