Sean E O'Malley from Honolulu, HI, age 35

Us Patents

Structural Carotenoid Analogs For The Inhibition And Amelioration Of Disease
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US Patent:

7145025, Dec 5, 2006
Filed:

Jul 29, 2003
Appl. No.:

10/629538
Inventors:

Samuel Fournier Lockwood - Lago Vista TX, US
Sean O'Malley - Honolulu HI, US
David G. Watumull - Honolulu HI, US
Laura M. Hix - Honolulu HI, US
Henry Jackson - Honolulu HI, US
Geoff Nadolski - Kaaawa HI, US
Assignee:

Hawaii Biotech, Inc. - Aiea HI
International Classification:

A61K 31/341
US Classification:

549473
Abstract:

A method for inhibiting and/or ameliorating the occurrence of diseases associated with reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals in a subject whereby a subject is administered a carotenoid structural analog, either alone or in combination with another carotenoid analog, or co-antioxidant formulation. The analog or analog combination is administered such that the subject's risk of experiencing diseases associated with reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals may be thereby reduced. The analog or analog combination may be administered to a subject for the inhibition and/or amelioration of ischemia-reperfusion injury, liver disease, cancer, cardiac arrhythmia and/or sudden cardiac death, and/or any disease that involves production of reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals. In one embodiment, a water-soluble and/or water-dispersible astaxanthin analog is particularly effective. This invention further includes pharmaceutical compositions comprising structural carotenoid analogs either alone or in combination.

Carotenoid Ester Analogs Or Derivatives For The Inhibition And Amelioration Of Ischemic Reperfusion Injury
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US Patent:

7317008, Jan 8, 2008
Filed:

Mar 4, 2004
Appl. No.:

10/793703
Inventors:

Samuel Fournier Lockwood - Lake Linden MI, US
Sean O'Malley - Honolulu HI, US
David G. Watumull - Honolulu HI, US
Laura M. Hix - San Francisco CA, US
Henry Jackson - Honolulu HI, US
Geoff Nadolski - Kaaawa HI, US
Assignee:

Cardax Pharmaceuticals, Inc. - Aiea HI
International Classification:

A61K 31/34
A61K 31/40
A61K 31/53
US Classification:

5142322, 514266, 514423, 514473
Abstract:

A method of treating ischemic reperfusion injury in a subject. The method may include administering to the subject an effective amount of a pharmaceutically acceptable formulation. The pharmaceutically acceptable formulation may include a synthetic analog or derivative of a carotenoid. The subject may be administered a carotenoid analog or derivative, either alone or in combination with another carotenoid analog or derivative, or co-antioxidant formulation. The carotenoid analog may include a conjugated polyene with between 7 to 14 double bonds. The conjugated polyene may include a cyclic ring including at least one substituent. In some embodiments, a cyclic ring of a carotenoid analog or derivative may include at least one substituent. The substituent may be coupled to the cyclic ring with an ester functionality.

Pharmaceutical Compositions Including Carotenoid Ester Analogs Or Derivatives For The Inhibition And Amelioration Of Disease
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US Patent:

7320997, Jan 22, 2008
Filed:

Mar 4, 2004
Appl. No.:

10/793692
Inventors:

Samuel Fournier Lockwood - Lake Linden MI, US
Sean O'Malley - Honolulu HI, US
David G. Watumull - Honolulu HI, US
Laura M. Hix - San Francisco CA, US
Henry Jackson - Honolulu HI, US
Geoff Nadolski - Kaaawa HI, US
Assignee:

Cardax Pharmaceuticals, Inc. - Aiea HI
International Classification:

A61K 31/341
US Classification:

514473
Abstract:

A method for inhibiting and/or ameliorating the occurrence of diseases associated with reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals in a subject whereby a subject is administered a carotenoid analog or derivative, either alone or in combination with another carotenoid analog or derivative, or co-antioxidant formulation. The analog or derivative is administered such that the subject's risk of experiencing diseases associated with reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals may be thereby reduced. In some embodiments, the invention may include a pharmaceutical composition including a carotenoid analog or derivative. The carotenoid analog may include a conjugated polyene with between 7 to 14 double bonds. The conjugated polyene may include a cyclic ring including at least one substituent. The substituent may be coupled to the cyclic ring with an ester functionality.

Carotenoid Ether Analogs Or Derivatives For The Inhibition And Amelioration Of Disease
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US Patent:

7345091, Mar 18, 2008
Filed:

Mar 4, 2004
Appl. No.:

10/793671
Inventors:

Samuel Fournier Lockwood - Lake Linden MI, US
Sean O'Malley - Honolulu HI, US
David G. Watumull - Honolulu HI, US
Laura M. Hix - San Francisco CA, US
Henry Jackson - Honolulu HI, US
Geoff Nadolski - Kaaawa HI, US
Assignee:

Cardax Pharmaceuticals, Inc. - Aiea HI
International Classification:

A61K 31/341
A61K 31/351
US Classification:

514460, 514473
Abstract:

A method for inhibiting and/or ameliorating the occurrence of diseases associated with reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals in a subject whereby a subject is administered a carotenoid analog or derivative, either alone or in combination with another carotenoid analog or derivative, or co-antioxidant formulation. The analog or derivative is administered such that the subject's risk of experiencing diseases associated with reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals may be thereby reduced. In some embodiments, the invention may include a chemical compound including an at least partially water soluble carotenoid analog or derivative. The carotenoid analog may include a conjugated polyene with between 7 to 14 double bonds. The conjugated polyene may include a cyclic ring including at least one substituent.

Pharmaceutical Compositions Including Carotenoid Ether Analogs Or Derivatives For The Inhibition And Amelioration Of Disease
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US Patent:

7375133, May 20, 2008
Filed:

Mar 4, 2004
Appl. No.:

10/793680
Inventors:

Samuel Fournier Lockwood - Lake Linden MI, US
Sean O'Malley - Honolulu HI, US
David G. Watumull - Honolulu HI, US
Laura M. Hix - San Francisco CA, US
Henry Jackson - Honolulu HI, US
Geoff Nadolski - Kaaawa HI, US
Assignee:

Cardax Pharmaceuticals, Inc. - Aiea HI
International Classification:

A61K 31/341
A61K 31/351
US Classification:

514460, 514473
Abstract:

A method for inhibiting and/or ameliorating the occurrence of diseases associated with reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals in a subject whereby a subject is administered a carotenoid analog or derivative, either alone or in combination with another carotenoid analog or derivative, or co-antioxidant formulation. The analog or derivative is administered such that the subject's risk of experiencing diseases associated with reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals may be thereby reduced. The analog or analog combination may be administered to a subject for the inhibition and/or amelioration of any disease that involves production of reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals. In some embodiments, the invention may include a pharmaceutical composition including a carotenoid analog or derivative. The carotenoid analog may include a conjugated polyene with between 7 to 14 double bonds.

Carotenoid Analogs Or Derivatives For The Inhibition And Amelioration Of Disease
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US Patent:

7521584, Apr 21, 2009
Filed:

Mar 4, 2004
Appl. No.:

10/793670
Inventors:

Samuel Fournier Lockwood - Lake Linden MI, US
Sean O'Malley - Honolulu HI, US
David G. Watumull - Honolulu HI, US
Laura M. Hix - San Francisco CA, US
Henry Jackson - Honolulu HI, US
Geoff Nadolski - Kaaawa HI, US
Assignee:

Cardax Pharmaceuticals, Inc. - Aiea HI
International Classification:

C07C 403/24
US Classification:

585351
Abstract:

A method for inhibiting and/or ameliorating the occurrence of diseases associated with reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals in a subject whereby a subject is administered a carotenoid analog or derivative, either alone or in combination with another carotenoid analog or derivative, or co-antioxidant formulation. The analog or derivative is administered such that the subject's risk of experiencing diseases associated with reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals may be thereby reduced. The analog or analog combination may be administered to a subject for the inhibition and/or amelioration of any disease that involves production of reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals. In some embodiments, the invention may include a chemical compound including an analog or derivative of a carotenoid. The carotenoid analog or derivative may be synthetic.

Structural Carotenoid Analogs For The Inhibition And Amelioration Of Disease
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US Patent:

7592449, Sep 22, 2009
Filed:

Feb 17, 2006
Appl. No.:

11/357897
Inventors:

Samuel Fournier Lockwood - Lago Vista TX, US
Sean O'Malley - Honolulu HI, US
David G. Watumull - Honolulu HI, US
Laura M. Hix - Honolulu HI, US
Henry Jackson - Honolulu HI, US
Geoff Nadolski - Kaaawa HI, US
Assignee:

Cardax Pharmaceuticals, Inc. - Aiea HI
International Classification:

C07D 233/12
C07D 265/30
C07D 473/00
US Classification:

544106, 544264, 5483511, 549315, 549415
Abstract:

A method for inhibiting and/or ameliorating the occurrence of diseases associated with reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals in a subject whereby a subject is administered a carotenoid structural analog, either alone or in combination with another carotenoid analog, or co-antioxidant formulation. The analog or analog combination is administered such that the subject's risk of experiencing diseases associated with reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals may be thereby reduced. The analog or analog combination may be administered to a subject for the inhibition and/or amelioration of ischemia-reperfusion injury. The analog or analog combination may be administered to a subject for the inhibition and/or amelioration of liver disease. The analog or analog combination may be administered to a subject for the inhibition and/or amelioration of cancer.

Carotenoid Analogs Or Derivatives For The Inhibition And Amelioration Of Inflammation
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US Patent:

7691901, Apr 6, 2010
Filed:

Apr 14, 2005
Appl. No.:

11/106378
Inventors:

Samuel Fournier Lockwood - Lago Vista TX, US
Sean O'Malley - Honolulu HI, US
Henry Jackson - Honolulu HI, US
Geoff Nadolski - Kaneohe HI, US
Assignee:

Cardax Pharmaceuticals Inc. - Aiea HI
International Classification:

A61K 31/341
A61K 31/351
US Classification:

514460, 514473
Abstract:

A method for inhibiting and/or ameliorating the occurrence of diseases in a human subject whereby a subject is administered a carotenoid analog or derivative, either alone or in combination with another carotenoid analog or derivative. In some embodiments, the administration of analogs or derivatives of carotenoids may inhibit and/or ameliorate the occurrence of diseases in subjects. In some embodiments, analogs or derivatives of carotenoids may be water-soluble and/or water dispersible. Maladies that may be treated with analogs or derivatives of carotenoids embodied herein may include diseases that provoke or trigger an inflammatory response. In an embodiment, asthma may be treated with analogs or derivatives of carotenoids embodied herein. In an embodiment, administering analogs or derivatives of carotenoids embodied herein to a subject may control or affect the bioavailability of eicosanoids. In an embodiment, atherosclerosis may be treated with analogs or derivatives of carotenoids embodied herein.

Sean O'malley

About:

Born:

04 June 1992

Work:

Business category:

Musicians

Position:

Musician

Education:

Specialty:

Singer

Skills & Activities:

Activity:

Irish male singer

Sean O'malley

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Specialties:

Surgery , Neurological

Work:

Brain & Spine Center PC
1004 1 St N STE 150, Alabaster, AL 35007
2056210122 (phone), 2056210145 (fax)

Education:

Medical School
Univ Coll of Dublin, Nat'l Univ of Ireland, Fac of Med, Dublin, Ireland
Graduated: 1987

Procedures:

Carpal Tunnel Decompression
Craniotomy
Lumbar Puncture
Spinal Cord Surgery
Spinal Fusion
Spinal Surgery

Conditions:

Intervertebral Disc Degeneration
Intracranial Injury

Languages:

English

Description:

Dr. O'Malley graduated from the Univ Coll of Dublin, Nat'l Univ of Ireland, Fac of Med, Dublin, Ireland in 1987. He works in Alabaster, AL and specializes in Surgery , Neurological. Dr. O'Malley is affiliated with Princeton Baptist Medical Center and Shelby Baptist Medical Center.

Sean P. O'malley

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Specialties:

Pediatrics, Adolescent Medicine

Work:

Child Health Care Associates
8138 Oswego Rd, Liverpool, NY 13090
3156528800 (phone), 3156528808 (fax)

Child Health Care Associates
6700 Kirkville Rd STE 1A, East Syracuse, NY 13057
3154632013 (phone), 3154632019 (fax)

Education:

Medical School
SUNY Upstate Medical University
Graduated: 2003

Conditions:

Acute Bronchitis
Acute Conjunctivitis
Acute Pharyngitis
Acute Sinusitis
Acute Upper Respiratory Tract Infections

Languages:

English

Description:

Dr. O'Malley graduated from the SUNY Upstate Medical University in 2003. He works in Liverpool, NY and 1 other location and specializes in Pediatrics and Adolescent Medicine. Dr. O'Malley is affiliated with Crouse Hospital, St Josephs Hospital Health Center and Upstate University Hospital.