Sean M Plunkett

US Patent:

20030129250, Jul 10, 2003

Filed:

Nov 20, 2002

Appl. No.:

10/300726

Inventors:

Richard Batycky - Newton MA, US
George Grandolfi - Milford OH, US
Sean Plunkett - Westborough MA, US
Michael Lipp - Framingham MA, US
James Wright - Lexington MA, US

Assignee:

Advanced Inhalation Research Inc. - Cambridge MA

International Classification:

A61K031/58
A61K009/14
A61K009/16

US Classification:

424/490000, 514/176000

Abstract:

The invention is drawn to particles for oral drug delivery produced by spray-drying a dilute solution of a poorly soluble agent. The particles comprise regions of poorly soluble agent wherein the dissolution rate enhancement is between about 2-fold and about 25-fold compared to the agent in bulk form.

US Patent:

20210244895, Aug 12, 2021

Filed:

Sep 30, 2020

Appl. No.:

17/038564

Inventors:

- Chelsea MA, US
Brian Noble - Harvard MA, US
Tim Coker - Nashua NH, US
Sean Plunkett - Westborough MA, US

International Classification:

A61M 15/00

Abstract:

A device for puncturing a capsule to release a powdered medicament therefrom includes a chamber for receiving the capsule. The capsule includes opposing domes and a cylindrical wall portion defined by a capsule wall radius r. The device further includes a mechanism for puncturing at least one hole in at least one dome. A center of each hole is located within an annular puncture region situated at no less than 0.4 r, and a total surface area of all puncture holes is between about 0.5% and about 2.2% of a total surface area of the capsule. The annular puncture region may, for example, be situated between about 0.4 r and about 0.8 r, or between about 0.4 r and about 0.6 r.

US Patent:

20180289904, Oct 11, 2018

Filed:

Nov 15, 2017

Appl. No.:

15/813870

Inventors:

- Chelsea MA, US
Brian Noble - Harvard MA, US
Tim Coker - Nashua NH, US
Sean Plunkett - Westborough MA, US

International Classification:

A61M 15/00

Abstract:

A device for puncturing a capsule to release a powdered medicament therefrom includes a chamber for receiving the capsule. The capsule includes opposing domes and a cylindrical wall portion defined by a capsule wall radius r. The device further includes a mechanism for puncturing at least one hole in at least one dome. A center of each hole is located within an annular puncture region situated at no less than 0.4r, and a total surface area of all puncture holes is between about 0.5% and about 2.2% of a total surface area of the capsule. The annular puncture region may, for example, be situated between about 0.4r and about 0.8r, or between about 0.4r and about 0.6r.

US Patent:

20140150787, Jun 5, 2014

Filed:

Dec 19, 2012

Appl. No.:

13/719598

Inventors:

- Chelsea MA, US
Brian Noble - Harvard MA, US
Tim Coker - Nashua NH, US
Sean Plunkett - Westborough MA, US

Assignee:

Civitas Therapeutics, Inc. - Chelsea MA

International Classification:

A61M 15/00

US Classification:

12820315, 30358, 30366

Abstract:

A device for puncturing a capsule to release a powdered medicament therefrom includes a chamber for receiving the capsule. The capsule includes opposing domes and a cylindrical wall portion defined by a capsule wall radius r. The device further includes a mechanism for puncturing at least one hole in at least one dome. A center of each hole is located within an annular puncture region situated at no less than 0.4 r, and a total surface area of all puncture holes is between about 0.5% and about 2.2% of a total surface area of the capsule. The annular puncture region may, for example, be situated between about 0.4 r and about 0.8 r, or between about 0.4 r and about 0.6 r.