Robert F. Gremel - Huntington Beach CA Sean D. Plunkett - Mission Viejo CA Henry W. Palermo - Burbank CA Gary D. Reeder - Morrison CO Peter Z. Kubisa - Littleton CO Peter J. Hier - Castle Rock CO
Assignee:
Medtronic, Inc. - Minneapolis MN
International Classification:
A61M 136
US Classification:
422 44
Abstract:
Micro-conduit with enhanced wetting characteristics for use in providing a blood heat exchanger apparatus with improved heat exchange capability. The micro-conduit comprises a plurality of elongated fibers, which may be made of a hydrophobic material such as polypropylene or polyethylene. Each fiber is open at two opposing ends, and has an inner surface between the open ends. The inner surface is coated with a wetting agent, such as phosphatidyl choline or another ampiphilic material with a hydrophilic end and a hydrophobic end. The fibers may have a shape and size that without presence of the wetting agent, would otherwise substantially impair free passage of water. The micro-conduit may be provided as a heat exchanger micro-conduit wrapping material, wherein micro-conduit fibers are attached to a thin flexible interconnect, such as woven netting, to maintain the fibers at predetermined spacings in substantially parallel alignment with each other. The wrapping material is wrapped about an elongated spindle to provide a generally cylindrical heat exchange core. Opposing first and second seals are created by applying potting compound between fibers proximate the spindle's first end and proximate the spindle's second end.
Composition Of Matter Comprising An Imprinted Matrix Exhibiting Selective Binding Interactions Through Chelated Metals
Frances H. Arnold - Pasadena CA Pradeep Dhal - Pasadena CA Deborah Shnek - Pomona CA Sean Plunkett - Pasadena CA
Assignee:
California Institute of Technology - Pasadena CA
International Classification:
A01N 102 C12Q 170 C12Q 104 C12N 500
US Classification:
435 5
Abstract:
The invention provides an imprinted matrix which exhibits selective binding interactions through metal chelates with a predetermined molecule or biological particle. Also provided is a preformed, fluid-imprinted matrix having sufficient rigidity to maintain selective binding interaction with a predetermined molecule or biological particle through interactive moieties. Methods for producing such matrices are additionally provided.