Seetharamaiyer Padmanabhan

US Patent:

7041702, May 9, 2006

Filed:

Oct 20, 1998

Appl. No.:

09/176067

Inventors:

Graham J. Durant - Plymouth, GB
Seetharamaiyer Padmanabhan - Malden MA, US

Assignee:

Scion Pharmaceuticals, Inc. - Medford MA

International Classification:

A61K 31/47
A61K 31/41
A61K 31/40
A61K 31/38
A61K 31/34

US Classification:

514617, 514618, 514622, 514623, 514311, 514314, 514355, 514414, 514415, 514448, 514471, 564161, 564162, 564170, 564174, 564176, 564177, 564179, 564182, 564183, 564184, 564185, 546165, 5462774, 5462804, 5462834, 546332, 548454, 548455, 548465, 548491, 549 72, 549487

Abstract:

The present invention relates to pharmaceutically acceptable compounds, including acylguanidine compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are particularly useful for the treatment or prophylaxis of neurological injury and neurodegenerative disorders.

US Patent:

8076303, Dec 13, 2011

Filed:

Dec 12, 2006

Appl. No.:

11/637520

Inventors:

Radhakrishnan P. Iyer - Shrewsbury MA, US
Seetharamaiyer Padmanabhan - Lexington MA, US

Assignee:

Spring Bank Pharmaceuticals, Inc. - Milford MA

International Classification:

A01N 43/04
A61K 48/00
A61K 31/70
C07H 19/00
C07H 19/04

US Classification:

514 43, 514 44 R, 514 48, 514 52, 536 221, 536 261

Abstract:

The present invention discloses compounds of formula (I):.

US Patent:

8287700, Oct 16, 2012

Filed:

Dec 17, 2009

Appl. No.:

12/641002

Inventors:

Seetharamaiyer Padmanabhan - Lexington MA, US
Radhakrishnan P. Iyer - Shrewsbury MA, US

Assignee:

Spring Bank - Milford MA

International Classification:

C07D 213/61
C07H 21/04

US Classification:

20415771, 20415764, 20415763, 2041576, 20415787

Abstract:

The present invention describes extremely rapid and efficient methods for the attachment of chemical moieties to matrices by the use of microwave technology. The methods of the invention can be applied in a variety of ways for the preparation of different types of matrices for a variety of applications including but not limited to the functionalization of various solid supports, and matrices in the form of powder, beads, sheets, and other suitable surfaces for use in applications including but not limited to oligonucleotide synthesis, peptide synthesis, environmental clean up (removal of toxic materials), immunoassays, affinity chromatography, combinatorial chemistry, microarrays, proteomics and medical diagnostics.

US Patent:

8404651, Mar 26, 2013

Filed:

Oct 4, 2010

Appl. No.:

12/897389

Inventors:

Radhakrishnan P. Iyer - Shrewsbury MA, US
Seetharamaiyer Padmanabhan - Lexington MA, US

Assignee:

Spring Bank Pharmaceuticals, Inc. - Milford MA

International Classification:

A01N 43/04
A61K 31/70

US Classification:

514 43, 514 45, 514 46, 514 47, 514 48, 514 49, 514 50, 514 51

Abstract:

The present invention provides compositions methods for treating susceptible viral infections, especially hepatitis C viral (HCV) infections as well as co infections of HCV with other viruses such as HBV and/or HIV. In one embodiment, the present invention provides compositions having the formula (I) and their use in treating viral infections:.

US Patent:

20050239112, Oct 27, 2005

Filed:

Mar 31, 2005

Appl. No.:

11/095077

Inventors:

Seetharamaiyer Padmanabhan - Lexington MA, US
Radhakrishnan Iyer - Shrewsbury MA, US

Assignee:

Migenix, Inc. - Vancouver

International Classification:

C12Q001/68
C12M001/34
B05D003/00

US Classification:

435006000, 435287200, 427002110

Abstract:

The present invention describes extremely rapid and efficient methods for the attachment of chemical moieties to matrices by the use of microwave technology. The methods of the invention can be applied in a variety of ways for the preparation of different types of matrices for a variety of applications including but not limited to the functionalization of various solid supports, and matrices in the form of powder, beads, sheets, and other suitable surfaces for use in applications including but not limited to oligonucleotide synthesis, peptide synthesis, environmental clean up (removal of toxic materials), immunoassays, affinity chromatography, combinatorial chemistry, microarrays, proteomics and medical diagnostics.

US Patent:

20060014176, Jan 19, 2006

Filed:

May 25, 2005

Appl. No.:

11/137677

Inventors:

Radhakrishnan Iyer - Shrewsbury MA, US
Seetharamaiyer Padmanabhan - Lexington MA, US
John Coughlin - Auburn MA, US

International Classification:

C12Q 1/68
G01N 33/53
C12M 1/34
C07K 1/02
C07H 21/04

US Classification:

435006000, 435007100, 530333000, 536025300, 435287200

Abstract:

The present invention relates to the design and use of a multipurpose reactor that may be adapted to accommodate a wide variety of solid phase and liquid phase reaction chemistries.

US Patent:

20060270741, Nov 30, 2006

Filed:

Mar 17, 2006

Appl. No.:

11/384006

Inventors:

Graham Durant - Plymouth, GB
Seetharamaiyer Padmanabhan - Lexington MA, US

Assignee:

Scion Pharmaceuticals, Inc. - Medford MA

International Classification:

A61K 31/16
C07C 249/02

US Classification:

514614000, 564147000

Abstract:

The present invention relates to pharmaceutically acceptable compounds, including acylguanidine compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are particularly useful for the treatment or prophylaxis of neurological injury and neurodegenerative disorders.

US Patent:

20120264709, Oct 18, 2012

Filed:

Nov 14, 2011

Appl. No.:

13/296221

Inventors:

Radhakrishnan P. Iyer - Shrewsbury MA, US
Seetharamaiyer Padmanabhan - Lexington MA, US

Assignee:

Spring Bank Pharmaceuticals, Inc. - Milford MA

International Classification:

C07H 19/207
A61P 31/14
A61K 31/7076

US Classification:

514 48, 536 265

Abstract:

The present invention discloses compounds of formula (I):which exhibit antiviral properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of anti-HBV treatment. The invention also relates to methods of treating a HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.