Seung Taeck Lee

US Patent:

7912573, Mar 22, 2011

Filed:

Jun 17, 2008

Appl. No.:

12/140297

Inventors:

Seung H. Lee - Bellevue WA, US
Charles Z. Loboz - Redmond WA, US
Zhongsheng Yuan - Bellevue WA, US

Assignee:

Microsoft Corporation - Redmond WA

International Classification:

G01C 17/00

US Classification:

700182, 702179, 702189, 709200, 709223, 710 36, 718103, 718104

Abstract:

Analysis may be made of the amount that a load on a machine impacts the machine's performance. Performance counters on the machine record raw statistical data, such as a given resource's current utilization. The values of these counters may be captured. A n-bin histogram may be created that shows how many of the captured performance counter values occur within various ranges, such as 0-10% utilization, 10-20%, etc. A weight may be assigned to each bin. A weighted sum of the bins may be calculated by multiplying the number of occurrences in each bin by the bin's weight, and adding the products together. The weights may be chosen to reflect the relative amounts that particular performance counter values impact the overall performance of a machine. Thus, a metric that represents performance impact may be calculated based on the weighted sum.

US Patent:

8650180, Feb 11, 2014

Filed:

Jun 20, 2011

Appl. No.:

13/164573

Inventors:

Suman K. Nath - Redmond WA, US
Seung Ho Lee - Bellevue WA, US
Slawomir Smyl - Kirkland WA, US
Charles Z. Loboz - Redmond WA, US
Oliver Andrzej Kennedy - Lausanne, CH

Assignee:

Microsoft Corporation - Redmond WA

International Classification:

G06F 7/00
G06F 17/30

US Classification:

707713, 707736, 707758, 707769, 703 22

Abstract:

The subject disclosure is directed towards using fingerprints, comprising lists of simulation results corresponding to partial (random sampled) simulation results, to determine whether a full simulation may be avoided by reusing simulation results from a previous full simulation. Before running a full simulation, a current fingerprint is obtained via a partial simulation. If a previous fingerprint matches (is identical or similar to) the current fingerprint, the associated previous results are reused. Also described is indexing fingerprint data to facilitate efficient lookup-based fingerprint matching.

US Patent:

20180280387, Oct 4, 2018

Filed:

Feb 28, 2018

Appl. No.:

15/907858

Inventors:

- Foster City CA, US
Astrid Clarke - Bainbridge Island WA, US
Kevin S. Currie - North Bend WA, US
Julie A. Di Paolo - San Francisco CA, US
Jeffrey E. Kropf - Issaquah WA, US
Seung H. Lee - Sammamish WA, US
Jennifer R. Lo - Seattle WA, US
Scott A. Mitchell - Kenmore WA, US
Aaron C. Schmitt - Hamden CT, US
Sundaramoorthi Swaminathan - Burlingame CA, US
Jin-Ming Xiong - Guilford CT, US
Jianjun Xu - Seattle WA, US
Zhongdong Zhao - Bellevue WA, US

International Classification:

A61K 31/4985
A61K 31/5377
A61K 31/519
A61K 31/475

Abstract:

The present disclosure relates to compounds that are Syk inhibitors and to their use in the treatment of various disease states, including cancer and inflammatory conditions. In particular embodiments, the structure of the compounds is given by Formula I:wherein R, R, R, and Rare as described herein. The present disclosure further provides pharmaceutical compositions that include a compound of Formula I, or pharmaceutically acceptable salts thereof, and methods of using these compounds and compositions to treat conditions mediated by Syk. In certain embodiments, also disclosed are methods for treating a cancer in a subject (e.g., a human) in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of formula I, or a pharmaceutically acceptable salt thereof, in combination with a vinca-alkaloid, or a pharmaceutically acceptable salt thereof.

US Patent:

20170035755, Feb 9, 2017

Filed:

Oct 20, 2016

Appl. No.:

15/298950

Inventors:

- Foster City CA, US
ASTRID CLARKE - Bainbridge Island WA, US
KEVIN S. CURRIE - North Bend WA, US
JULIE A. DI PAOLO - San Francisco CA, US
JEFFREY E. KROPF - Issaquah WA, US
SEUNG H. LEE - Sammamish WA, US
JENNIFER R. LO - Seattle WA, US
SCOTT A. MITCHELL - Kenmore WA, US
AARON C. SCHMITT - Hamden CT, US
SUNDARAMOORTHI SWAMINATHAN - Burlingame CA, US
JIN-MING XIONG - Guilford CT, US
JIANJUN XU - Seattle WA, US
ZHONGDONG ZHAO - Bellevue WA, US

International Classification:

A61K 31/4985
A61K 31/475
A61K 31/5377

Abstract:

The present disclosure relates to compounds that are Syk inhibitors and to their use in the treatment of various disease states, including cancer and inflammatory conditions. In particular embodiments, the structure of the compounds is given by Formula I:wherein R, R, R, and Rare as described herein. The present disclosure further provides pharmaceutical compositions that include a compound of Formula I, or pharmaceutically acceptable salts thereof, and methods of using these compounds and compositions to treat conditions mediated by Syk. In certain embodiments, also disclosed are methods for treating a cancer in a subject (e.g., a human) in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of formula I, or a pharmaceutically acceptable salt thereof, in combination with a vinca-alkaloid, or a pharmaceutically acceptable salt thereof.

US Patent:

20160368918, Dec 22, 2016

Filed:

May 9, 2016

Appl. No.:

15/150038

Inventors:

- Foster City CA, US
Jayaraman Chandrasekhar - Redmond WA, US
Kevin S. Currie - North Bend WA, US
Zhimin Du - Belmont CA, US
Julie Farand - San Mateo CA, US
Juan A. Guerrero - Concord CA, US
Ashley A. Katana - North Olmsted OH, US
Darryl Kato - San Francisco CA, US
Jeffrey Kropf - Issaquah WA, US
Scott E. Lazerwith - San Francisco CA, US
Seung H. Lee - Sammamish WA, US
Jiayao Li - Foster City CA, US
John O. Link - San Francisco CA, US
Jennifer R. Lo - Seattle WA, US
Nicholas Mai - San Jose CA, US
Scott A. Mitchell - Kenmore WA, US
Gregory Notte - San Mateo CA, US
Hyung-jung Pyun - Fremont CA, US
Michael Sangi - San Mateo CA, US
Aaron C. Schmitt - Hamden CT, US
Adam J. Schrier - Redwood City CA, US
Kirk L. Stevens - Bothell WA, US
Chandrasekar Venkataramani - Redwood City CA, US
William J. Watkins - Saratoga CA, US
Jin Ming Xiong - Guilford CT, US
Jianjun Xu - Seattle WA, US
Zheng-Yu Yang - Palo Alto CA, US
Jeff Zablocki - Los Altos CA, US
Zhongdong Zhao - Bellevue WA, US
Sheila Zipfel - San Mateo CA, US

International Classification:

C07D 471/04
C07D 403/14
C07D 401/14
C07D 519/00
C07D 487/04
C07D 498/04
C07D 413/14
C07D 405/14
C07D 417/12
C07D 417/14
C07D 403/12
C07D 491/08

Abstract:

The present disclosure relates to compounds that are Syk inhibitors and to their use in the treatment of various disease states, including cancer and inflammatory conditions. In particular embodiments, the structure of the compounds is given by Formula I:wherein X, X, X, R, R, R, R, and Y are as described herein. The present disclosure further provides pharmaceutical compositions that include a compound of Formula I, or pharmaceutically acceptable salts thereof, and methods of using these compounds and compositions to treat conditions mediated by Syk.