Crye Leike Commercial
Realtor
Upper Manhattan Mental Health Center Aug 1989 - Jul 2001
Accontant and Grant Manager
Global Realty & Associates Aug 1989 - Jul 2001
Real Estate Agent
Education:
Kerala University 1975 - 1978
Bachelor of Commerce, Bachelors, Accounting
Skills:
Real Estate Foreclosures Sellers Investment Properties Short Sales Selling Commercial Real Estate Residential Homes First Time Home Buyers Mortgage Lending Reo Single Family Homes Real Estate Transactions
2001 to 2000 Exercise (A.C.E.) Personal TrainerAmerican Council on Exercise
2001 to 2000 Senior Balance and Coordination CoreAmerican Council on Exercise Dobbs Ferry, NY Oct 2009 to May 2010 Fitness TrainerAmerican Council on Exercise Yonkers, NY Oct 2002 to Dec 2003 Fitness TrainerAmerican Council on Exercise White Plains, NY Feb 2003 to Nov 2003 Master Trainer
Education:
Lehman College 2002 to 2000 BA in Business Management
Name / Title
Company / Classification
Phones & Addresses
Shaji George Mortgage Broker
Global Brokers Loan Brokers
4250 River Green Pkwy, Duluth, GA 30096
Shaji T. George President
Biopharm Laboratories Inc Mfg Biological Products
719 Carmans Rd, Bar Harbor, NY 11762
Shaji George Principal
Xtreme Indian Entertainment Entertainer/Entertainment Group
16 Hughes Ter, Yonkers, NY 10701
Shaji George Pastor
Emmanuel Church of South India C S I Congregation of Atlanta Religious Organization
2170 Pinehurst Rd, Lithonia, GA 30078
Shaji George Mortgage Broker
Global Brokers
4250 Riv Grn Pkwy, Duluth, GA 30096 7704474471, 7704474471
Us Patents
Phenotypic Conversion Of Cells Mediated By External Guide Sequences
Disclosed are a method and compositions for delivering nucleic acids to bacterial cells. The method does not require manipulation of the bacteria and is therefore particularly suited to delivery of nucleic acids to bacteria in natural environments, including inside animals bodies. The method generally involves conjugating the nucleic acid to be delivered with a cationic porphyrin and bringing the conjugate and the target bacterial cells into contact. Both the porphyrin and conjugated nucleic acid are taken up by the bacterial cells and the nucleic acid can then have a biological effect on the cells. Specifically disclosed is a method for converting drug-resistant bacterial cells to drug-sensitive cells by delivery of external guide sequences to the cells which then promote cleavage of RNA molecules involved in conferring the drug-resistant phenotype on the cells. The drug-resistant phenotype of the cells is thus converted to a drug-sensitive phenotype. The drug-sensitive cells are then susceptible to drug therapy.
Phenotypic Conversion Of Cells Mediated By External Guide Sequences
Garry B. Takle - New York NY Allan R. Goldberg - New York NY Shaji T. George - New York NY
Assignee:
Yale University - New Haven CT
International Classification:
C12Q 168
US Classification:
435 6, 435 691, 435471, 540145
Abstract:
Disclosed are a method and compositions for delivering nucleic acids to bacterial cells. The method does not require manipulation of the bacteria and is therefore particularly suited to delivery of nucleic acids to bacteria in natural environments, including inside animals bodies. The method generally involves conjugating the nucleic acid to be delivered with a cationic porphyrin and bringing the conjugate and the target bacterial cells into contact. Both the porphyrin and conjugated nucleic acid are taken up by the bacterial cells and the nucleic acid can then have a biological effect on the cells. Specifically disclosed is a method for converting drug-resistant bacterial cells to drug-sensitive cells by delivery of external guide sequences to the cells which then promote cleavage of RNA molecules involved in conferring the drug-resistant phenotype on the cells. The drug-resistant phenotype of the cells is thus converted to a drug-sensitive phenotype. The drug-sensitive cells are then susceptible to drug therapy.
Garry B. Takle - New York NY Shaji T. George - New York NY
Assignee:
Yale University - New Haven CT Sirna Therapeutics, Inc. - Boulder CO
International Classification:
A01N 5502
US Classification:
514185, 514410, 514 44, 536 2372
Abstract:
Efficient methods and compositions are provided for the targeted delivery of effective concentrations of compounds, including nucleic acid molecules and oligonucleotides such as EGSs, ribozymes and antisense, proteins, peptides, carbohydrate, and synthetic organic and inorganic molecules, or combinations thereof, to cells, especially hepatocytes. In the preferred embodiment, the compound is an negatively charged oligonucleotide which binds in a stoichiometric ratio to a water soluble, positively charged macrocycle such as a porphyrin, which targets and protects the oligonucleotide. The porphyrin protects the compound to be delivered and delivers the compound preferentially to certain cells and tissue types. In another embodiment, the porphyrin has anti-human hepatitis virus activity, when administered alone, which is significantly enhanced when in combination with an antiviral compound, especially an oligonucleotide.
Therapeutic Ribozyme Compositions And Expression Vectors
Allan R. Goldberg - New York NY Shaji T. George - New York NY Hugh D. Robertson - New York NY
Assignee:
Innovir Laboratories, Inc. - New York NY
International Classification:
C12N 1500 C12Q 168 C07H 1512 C12P 1934
US Classification:
4353201
Abstract:
Hepatitis delta is used as a vector for inhibition of viral infection and to express proteins in vivo in a cell-specific manner. The scope of delta's use as a vector is broadened in the present invention in several important ways. For example, a delta RNA genome capable of self-replication is enlarged to carry additional information, either coding for messenger RNA for a protein, or for a targeted ribozyme, which can be delivered to liver cells using delta's normally infectious properties, or to other cell types using chimeric delta viral agents carrying altered surface proteins. In another embodiment, the delta vector is made self-limiting, so that its role in delivering targeted information is separated from its viral property of unlimited infectious replication. Targeting is achieved through the use of sequences flanking the delta sequences that have affinity for sites on RNA to be cleaved.
Hepatitis Delta Virus Compositions And Expression Vectors
Allan R. Goldberg - New York NY Shaji T. George - New York NY Hugh D. Robertson - New York NY
Assignee:
Innovir Laboratories, Inc. - New York NY
International Classification:
C12N 1585 C12N 1586 C12N 1563 C12N 701
US Classification:
4353201
Abstract:
Hepatitis delta is used as a vector for inhibition of viral infection and to express proteins in vivo in a cell-specific manner. The scope of delta's use as a vector is broadened in the present invention in several important ways. For example, a delta RNA genome capable of self-replication is enlarged to carry additional information, either coding for messenger RNA for a protein, or for a targeted ribozyme, which can be delivered to liver cells using delta's normally infectious properties, or to other cell types using chimeric delta viral agents carrying altered surface proteins. In another embodiment, the delta vector is made self-limiting, so that its role in delivering targeted information is separated from its viral property of unlimited infectious replication. Targeting is achieved through the use of sequences flanking the delta sequences that have affinity for sites on RNA to be cleaved.
Regulatable Nucleic Acid Therapeutic And Methods Of Use Thereof
Shaji T. George - New York NY Andy Shih - New York NY Jeffrey Michael Bockman - New York NY
Assignee:
Innovir Laboratories, Inc. - New York NY
International Classification:
C12P 1934 C07H 2104
US Classification:
435 9131
Abstract:
Regulatable RNA molecules such as regulatable ribozymes, nucleic acids encoding such regulatable ribozymes, and methods of making and using such regulatable ribozymes are disclosed. Regulatable ribozymes comprise a ligand-binding RNA sequence and a ribozyme sequence capable of cleaving a separate targeted RNA sequence, wherein upon binding of the ligand to the ligand-binding RNA sequence, the activity of the ribozyme sequence against the targeted RNA sequence is altered. The ligand may be either an inorganic or an organic molecule and may be a co-drug which can be administered to specifically regulate the ribozyme activity. Regulatable RNA molecules other than ribozymes are also disclosed, such as regulatable mRNA molecules which comprise a ligand-binding RNA sequence separate from the coding sequence, wherein upon binding of a ligand to the ligand-binding RNA sequence, translation of the regulatable mRNA is altered.
Andy Shih - New York NY Jeffrey M. Bockman - New York NY Shaji T. George - New York NY
Assignee:
Innovir Laboratories, Inc. - New York NY
International Classification:
C12Q 168 C07H 2102 C07H 2104
US Classification:
435 6
Abstract:
A system is described for the use of a ribozyme as a diagnostic tool for detecting the presence of a nucleic acid, protein, or other molecule, in which the formation of an active ribozyme and cleavage of an assayable marker is dependent on the presence or absence of the specific target molecule. The essential component is a ribozyme specifically but reversibly binding a selected target in combination with a labelled co-target, preferably immobilized on a support structure. When both the target and co-target are bound, the ribozyme cleaves the label from the co-target, which is then quantifiable. Since the ribozyme is reversibly bound by target and co-target, it can reassociate with additional co-target, cleaving more label, thereby amplifying the reaction signal. In one embodiment, the target is a nucleic acid hybridizing to complementary sequences that form part of the ribozyme; in a second embodiment, the target is a protein or other macromolecule which is bound by interactions with a portion of the ribozyme molecule in another embodiment, a thermostable ribozyme is used, so that improperly bound ribozyme is destabilized and inactive at elevated temperatures. A method for isolating regularable ribozymes is also disclosed.
Shaji T. George - New York NY Michael Ma - New York NY Martina Werner - New York NY Umberto Pace - Riverdale NY Allan R. Goldberg - New York NY
Assignee:
Yale University - New Haven CT
International Classification:
C12N 1563 C12N 1585 C07H 2104
US Classification:
4353201
Abstract:
Modified external guide sequence (EGS) molecules that mediate cleavage of specific target RNAs have been constructed. The modified molecules are external guide sequence molecules for RNAse P which are designed to specifically bind to and promote RNAse P-mediated cleavage of target RNA molecules and to have enhanced nuclease resistance. Specific regions are modified to achieve enhanced stability while maintaining RNAse P activity. Modified external guide sequence molecules suitable for use in the treatment of hepatitis B viral infections have been constructed.
REO / Bank Owned Short sales Residential sales Luxury homes First time home buyers Distressed properties Relocation
Work:
Global Brokers Realty LLC Lawrenceville, GA 6789055682 (Phone) License #266490
Certifications:
ABR SFR e-PRO BPOR
Client type:
Home Buyers Home Sellers
Property type:
Single Family Home Condo/Townhome Multi-family
Languages:
English
Skills:
Negotiating short sale and get pre approved. Multiple offer scenarios for Bank owned properties.
About:
I love helping people obtain their goals in real estate. Being a full time Realtor since 2001 and keeping up with the changing real estate market, experience in the foreclosure market, I can help my clients get what they are paying for and more! With a professional yet friendly approach, I help clients feel comfortable about what can be a stressful decision. Â With my experience specifically in Real Estate Sales and Negotiation, I have honed my knowledge and skill of the industry for your benefit. Trust is hard to come by in today's fiercely competitive real estate market. I am here to provide you with the professionalism and integrity needed to ensure that you feel secure in what can be one of the biggest decisions of your life. If you would like to buy your dream home give me a call 678 471 8275 and you will be fully satisfied. However, when it comes to getting your home SOLD I am the best choice. My marketing skills mainly Technology and Internet oriented along with the vast knowledge of buyers' mentalities will warrantee that I WILL GET YOUR HOME SOLD. Who will be better than someone who understands the Buyer's mindset to give you Selling Tips and Advice. All my listings are advertised in the leading sites such as TRULIA, ZILLOW, Realtor.com, Market Leader, Fmls and Gamls among others. Selling is a challenge I take on a daily basis in any Real Estate Market Conditions.
Googleplus
Shaji George
Lived:
Yonkers, NY
Work:
S.H.A.J.I. is THE ANSWER - Life and Fitness Coach (1997)
Education:
American Heart Association - Adult CPR, American Council on Exercise - Personal Trainer, Lehman College - Business Management, Westchester Community College - Business Administration
Relationship:
Married
About:
My name is Shaji George. I am 39 years old and lived in Yonkers, NY all my life. I am Life Coach and ACE Personal Trainer. I am married and have a 3 year old baby girl.Â
Bragging Rights:
I have been extra on NBC's "Saturday Night Live" several times.
My name is Shaji George and I was born on June 6, 1973 in Yonkers,NY.  I graduated from Lehman College in 1997 with a Bachelor's Degree in Business Management. In addition, I am a certified ACE Pe...