Shane C Weber

US Patent:

6677121, Jan 13, 2004

Filed:

May 15, 2001

Appl. No.:

09/855793

Inventors:

Paul M. Lizardi - Wallingford CT
Matthew E. Roth - Branford CT
Li Feng - Hamden CT
Cesar E. Guerra - Guilford CT
Shane C. Weber - Woodbridge CT
Joseph C. Kaufman - Hamden CT
Darin R. Latimer - East Haven CT

Assignee:

Agilix Corporation - New Haven CT
Yale University - New Haven CT

International Classification:

C12Q 168

US Classification:

435 6, 435 912, 536 231, 536 242, 536 243

Abstract:

Disclosed is a method for the comprehensive analysis of nucleic acid samples and a detector composition for use in the method. The method, referred to as Fixed Address Analysis of Sequence Tags (FAAST), involves generation of a set of nucleic acid fragments having a variety of sticky end sequences; indexing of the fragments into sets based on the sequence of sticky ends; associating a detector sequence with the fragments; sequence-based capture of the indexed fragments on a detector array; and detection of the fragment labels. Generation of the multiple sticky end sequences is accomplished by incubating the nucleic acid sample with one or more nucleic acid cleaving reagents. The indexed fragments are captured by hybridization and coupling, preferably by ligation, to a probe. The method allows a complex sample of nucleic acid to be quickly and easily cataloged in a reproducible and sequence-specific manner. One form of the method allows determination of associations, in a nucleic acid molecule, of different combinations of known or potential sequences.

US Patent:

6682893, Jan 27, 2004

Filed:

Aug 21, 2001

Appl. No.:

09/934420

Inventors:

Seth Taylor - Cambridge MA 02142
Kevin Croker - Cheshire CT 06410-3658
Shane Weber - Woodbridge CT 06525-1025

International Classification:

C12Q 168

US Classification:

435 6, 424488, 424486, 436501, 536 231

Abstract:

Gel pads and gel pad arrays, and methods for making and using them, are disclosed. The gel pads preferably comprise an intelligent gel.

US Patent:

20040253613, Dec 16, 2004

Filed:

Jan 27, 2004

Appl. No.:

10/765579

Inventors:

Seth Taylor - Cambridge MA, US
Kevin Croker - Cheshire CT, US
Shane Weber - Woodbridge CT, US

International Classification:

C12Q001/68
C12M001/34
B05D003/00

US Classification:

435/006000, 435/287200, 427/002110

Abstract:

Gel pads and gel pad arrays, and methods for making and using them, are disclosed. The gel pads preferably comprise an intelligent gel.

US Patent:

55807127, Dec 3, 1996

Filed:

Feb 3, 1995

Appl. No.:

8/383348

Inventors:

John E. Keevert - Rochester NY
Shane C. Weber - Woodbridge CT
Ramesh Jagannathan - Rochester NY
Gerald W. Klein - Issaquah WA

Assignee:

Eastman Kodak Company - Rochester NY

International Classification:

G03C 1015
G03C 1047
C12P 2100

US Classification:

430569

Abstract:

Certain synthetically prepared biopolymers are useful as peptizers in the preparation of photographic silver halide emulsions and elements. Such materials can be used as either nucleation or growth peptizers in place of common peptizing colloids, such as gelatins. The biopolymers can be prepared using recombinant or chemical synthetic methods and designed to have a particular affinity (either high or low) for silver ions. Thus, they can be used to control silver halide grain morphology in the emulsions.

US Patent:

56706162, Sep 23, 1997

Filed:

Feb 3, 1995

Appl. No.:

8/383804

Inventors:

Shane Crawford Weber - Woodbridge CT
John Alan McElver - Des Moines IA

Assignee:

Eastman Kodak Company - Rochester NY

International Classification:

C07K 700
C07K 1400

US Classification:

530300

Abstract:

Synthetic biopolymers can be prepared using recombinant DNA technology or chemical synthetic methods which have properties similar to naturally occuring gelatin or collagen. These materials comprise one or more polypeptides having the peptide sequence represented by the formulae I: {�(Gly Pro Gln)(Gly Pro Glu). sub. 4 !. sub. 2 }. sub. n II: Gly Pro Glu{�(Gly Pro Gln)(Gly Pro Glu). sub. 4 !. sub. 2 }. sub. n III: Gly Pro Xaa. sub. 1 Gly Leu Xaa. sub. 2 Gly Pro Arg Gly Pro Pro Gly Ala Set Gly Ala Pro Gly Pro Glu Gly Phe Gln Gly wherein Xaa. sub. 1 and Xaa. sub. 2 are independently the amino acids identified as Met, Ile, His, Lys, Asn, Tyr or Gln, and n is 1 to 25.

US Patent:

58010459, Sep 1, 1998

Filed:

Mar 10, 1997

Appl. No.:

8/814309

Inventors:

Shane Crawford Weber - Woodbridge CT
John Alan McElver - Des Moines IA

Assignee:

Eastman Kodak Company - Rochester NY

International Classification:

C12N 111
C12N 115
C12N 121

US Classification:

4352523

Abstract:

Synthetic biopolymers can be prepared using recombinant DNA technology or chemical synthetic methods which have properties similar to naturally occuring gelatin or collagen. These materials comprises one or more polypeptides having the peptide sequence represented by the formulae: ##STR1## wherein Xaa. sub. 1 and Xaa. sub. 2 are independently the amino acids identified as Met, Ile, His, Lys, Asn, Tyr or Gln, and n is 1 to 25.

US Patent:

53858190, Jan 31, 1995

Filed:

Dec 22, 1993

Appl. No.:

8/171588

Inventors:

Wayne A. Bowman - Walworth NY
Roger A. Weiss - Webster NY
Gerald W. Klein - Issaquah NY
John E. Keevert - Rochester NY
Shane C. Weber - Rochester NY

Assignee:

Eastman Kodak Company - Rochester NY

International Classification:

G03C 1015
G03C 1005
G03C 104

US Classification:

430569

Abstract:

A process for preparing a thin tabular grain silver halide emulsion comprised of silver halide grains which have a halide content of at least 50 mole percent bromide, wherein tabular grains of less than 0. 15 micrometers in thickness and having an aspect ratio of greater than 8 account for greater than 50 percent of the total grain projected area, comprises the steps of nucleating the silver halide grains with a gelatino-peptizer or with the use of certain synthetic polymers that serve as effective nucleation peptizers and then growing the silver halide grains with the use of either a gelatino-peptizer or certain synthetic polymers that serve as effective growth peptizers.

US Patent:

62617826, Jul 17, 2001

Filed:

Apr 6, 2000

Appl. No.:

9/544713

Inventors:

Paul M. Lizardi - Wallingford CT
Matthew E. Roth - Branford CT
Li Feng - Hamden CT
Cesar E. Guerra - Guilford CT
Shane C. Weber - Woodbridge CT
Joseph C. Kaufman - Hamden CT
Darin R. Latimer - East Haven CT

Assignee:

Yale University - New Haven CT

International Classification:

C12Q 168
C07H 2104
C12P 1934

US Classification:

435 6

Abstract:

Disclosed is a method for the comprehensive analysis of nucleic acid samples and a detector composition for use in the method. The method, referred to as Fixed Address Analysis of Sequence Tags (FAAST), involves generation of a set of nucleic acid fragments having a variety of sticky end sequences; indexing of the fragments into sets based on the sequence of sticky ends; associating a detector sequence with the fragments; sequence-based capture of the indexed fragments on a detector array; and detection of the fragment labels. Generation of the multiple sticky end sequences is accomplished by incubating the nucleic acid sample with one or more nucleic acid cleaving reagents. The indexed fragments are captured by hybridization and coupling, preferably by ligation, to a probe. The method allows a complex sample of nucleic acid to be quickly and easily cataloged in a reproducible and sequence-specific manner. One form of the method allows determination of associations, in a nucleic acid molecule, of different combinations of known or potential sequences.