Shanker Avantika Gupta

US Patent:

6682758, Jan 27, 2004

Filed:

Jun 21, 2001

Appl. No.:

09/868858

Inventors:

S. Esmail Tabibi - Rockville MD
Emmanuel I. Ezennia - Baltimore MD
B. Rao Vishnuvajjala - Rockville MD
Shanker Gupta - Rockville MD

Assignee:

The United States of America as represented by the Department of Health and Human Services - Washington DC

International Classification:

A61K 9127

US Classification:

424450, 264 41, 264 43, 264 46

Abstract:

The present invention provides a drug delivery system comprising a water-insoluble drug, a water-miscible organic solvent for the water-insoluble drug, a surfactant, and water, as well as a process for preparing the same. This invention further provides a pharmaceutical composition comprising a pharmaceutically acceptable carrier and such a drug delivery system. In addition, the present invention provides a method of delivering a drug to a host by administering to the host the drug delivery system of the present invention.

US Patent:

6699835, Mar 2, 2004

Filed:

Jan 25, 2002

Appl. No.:

10/056563

Inventors:

Louis Plamondon - Watertown MA
Louis Grenier - Medford MA
Julian Adams - Brookline MA
Shanker Lal Gupta - Rockville MD

Assignee:

The United States of America as represented by the Department of Health and Human Services - Washington DC
Millennium Pharmaceuticals, Inc. - Cambridge MA

International Classification:

A61K 3800

US Classification:

514 2, 514 18, 514 19, 514 64, 536 171, 544229, 530322

Abstract:

The invention relates to the formulation of pharmaceutical compounds. More particularly, the invention provides stable, pharmaceutically acceptable compositions prepared from boronic acid compounds and methods for preparing the compositions. The invention also provides novel boronate ester compounds. The invention further provides boronic acid anhydride compounds useful in the methods of the invention.

US Patent:

6713446, Mar 30, 2004

Filed:

Jan 25, 2002

Appl. No.:

10/056567

Inventors:

Shanker Lal Gupta - Rockville MD

Assignee:

The United States of America as represented by the Secretary of the Department of Health and Human Services - Washington DC

International Classification:

A61K 3800

US Classification:

514 2, 514 18, 514 19, 514 64, 536 171, 562 7, 530322

Abstract:

The present invention provides stable compounds prepared from boronic acid and lyophilized compounds thereof of the formula (1): in which Z and Z are moieties derived from sugar. The invention also provides methods for preparing such compounds. Lyophilizing a mixture comprising a boronic acid compound and a moiety derived from sugar produces a stable composition that readily releases the boronic acid compound upon reconstitution in aqueous media.

US Patent:

6838090, Jan 4, 2005

Filed:

Jun 5, 2003

Appl. No.:

10/455295

Inventors:

S. Esmail Tabibi - Rockville MD, US
Emmanuel I. Ezennia - Baltimore MD, US
B. Rao Vishnuvajjala - Rockville MD, US
Shanker Gupta - Rockville MD, US

Assignee:

The United States of America as represented by the Department of Health and Human Services - Washington DC

International Classification:

A61K 9127

US Classification:

424450, 264 41, 264 43, 264 46

Abstract:

The present invention provides a drug delivery system comprising a water-insoluble drug, a water-miscible organic solvent for the water-insoluble drug, a surfactant, and water, as well as a process for preparing the same. This invention further provides a pharmaceutical composition comprising a pharmaceutically acceptable carrier and such a drug delivery system. In addition, the present invention provides a method of delivering a drug to a host by administering to the host the drug delivery system of the present invention.

US Patent:

6958319, Oct 25, 2005

Filed:

Sep 18, 2003

Appl. No.:

10/664732

Inventors:

Shanker Lal Gupta - Rockville MD, US

Assignee:

The United States of America as represented by the Department of Health and Human Services - Washington DC

International Classification:

A61K038/00
A61K033/22
C07K009/00
C07F005/02

US Classification:

514 2, 514 18, 514 19, 514 64, 536 171, 544229, 530322

Abstract:

The present invention provides stable compounds prepared from boronic acid and lyophilized compounds thereof of the formula (1): in which Zand Zare moieties derived from sugar. The invention also provides methods for preparing such compounds. Lyophilizing a mixture comprising a boronic acid compound and a moiety derived from sugar produces a stable composition that readily releases the boronic acid compound upon reconstitution in aqueous media.

US Patent:

7109323, Sep 19, 2006

Filed:

Dec 23, 2003

Appl. No.:

10/744843

Inventors:

Louis Plamondon - Watertown MA, US
Louis Grenier - Cambridge MA, US
Julian Adams - Brookline MA, US
Shanker Lal Gupta - Rockville MD, US

Assignee:

The United States of America as represented by the Department of Health and Human Services - Washington DC
Millennium Pharmaceutical, Inc. - Cambridge MA

International Classification:

C07H 3/00
A61K 38/00
A61K 33/22
C07K 9/00
C07F 5/02

US Classification:

536 53, 536 171, 514 2, 514 18, 514 19, 514 64, 544229, 530320

Abstract:

The invention relates to the formulation of pharmaceutical compounds. More particularly, the invention provides stable, pharmaceutically acceptable compositions prepared from boronic acid compounds and methods for preparing the compositions. The invention also provides novel boronate ester compounds. The invention further provides boronic acid anhydride compounds useful in the methods of the invention.

US Patent:

7169819, Jan 30, 2007

Filed:

Dec 5, 2001

Appl. No.:

10/010914

Inventors:

Shanker Gupta - Rockville MD, US
Barry J. Maurer - Sylmar CA, US
C. Patrick Reynolds - Sherman Oaks CA, US
B. Rao Vishnuvajjala - Rockville MD, US

Assignee:

Childrens Hospital Los Angeles - Los Angeles CA

International Classification:

A61K 31/07
A61K 47/00
A61P 35/00

US Classification:

514725, 514728, 514729, 514731, 514739, 514772, 514783, 514937, 514938, 514975

Abstract:

A pharmaceutical composition for parenteral delivery, comprising a retinide such as fenretinide in combination with a solvent capable of dispersing or solubilizing the retinide. The solvent comprises an alcohol, such as ethanol, in combination with an alkoxylated castor oil, such as CREMOPHOR EL, or comprising a retinide, such as fenretinide, in an emulsion composed of a lipoid dispersed in an aqueous phase, a stabilizing amount of a non-ionic surfactant, optionally a solvent, and optionally an isotonic agent. In addition, a method of use in the treatment of hyperproliferative disorders, such as cancers is described.

US Patent:

7476692, Jan 13, 2009

Filed:

Feb 19, 2004

Appl. No.:

10/782459

Inventors:

Shanker Gupta - Rockville MD, US
C. Patrick Reynolds - Sherman Oaks CA, US
Barry J. Maurer - Sylmar CA, US
B. Rao Vishnuvajjala - Rockville MD, US

Assignee:

Childrens Hospital Los Angeles - Los Angeles CA

International Classification:

A61K 31/19
A61K 31/13

US Classification:

514557, 514667

Abstract:

The present invention provides stable aqueous solutions consisting essentially of: (a) a sphingolipid; (b) lactic acid; and (c) optionally a stabilizing agent; wherein the solution has a molar ratio of lactic acid to sphingolipid of 1:1 to 10:1. The present invention further provides an emulsion formulation consisting essentially of: (a) lactic acid; (b) a sphingolipid, wherein the sphingolipid is present in an amount of about 0. 1 to about 30 mg/ml of emulsion; (b) optionally an isotonic agent; and (c) a phospholipid present in an amount of about 0. 2 to about 200 mg/ml of emulsion. Methods of making and using the compositions are also provided.