Shannon E Dixon

US Patent:

20180068838, Mar 8, 2018

Filed:

Nov 13, 2017

Appl. No.:

15/811530

Inventors:

- San Jose CA, US
Justin BLETHROW - Oakland CA, US
Shannon Eliuk DIXON - San Jose CA, US
Tonya SECOND - Corona CA, US
Vladimir ZABROUSKOV - Belmont CA, US
Eric HEMENWAY - Milpitas CA, US

International Classification:

H01J 49/00
H01J 49/06

Abstract:

A hybrid mass spectrometer design and architecture, and methods of operating mass spectrometers are disclosed. According to one operating method, an analysis time is determined for each one of a plurality of ion species to be analyzed in an ordered sequence, and an injection time is calculated for at least some of the ion species based on an analysis time of a preceding ion species in the ordered list. The method enables more efficient utilization of analyzer time.

US Patent:

20170345632, Nov 30, 2017

Filed:

May 25, 2016

Appl. No.:

15/164113

Inventors:

- San Jose CA, US
Shannon Eliuk DIXON - San Jose CA, US
Romain M. HUGUET - San Jose CA, US

International Classification:

H01J 49/00
G01N 30/72
G01N 33/68
H01J 49/42

Abstract:

A method and corresponding apparatus are disclosed for analysis of a peptide-containing sample. The sample is prepared by adding isotopically-labeled peptides corresponding to endogenous peptides of interest, and the prepared sample is analyzed by liquid chromatography-mass spectrometry (LCMS). Detection in a high-resolution, accurate mass (HRAM) MS1 spectrum of a precursor ion matching an isotopically-labeled peptide triggers acquisition of an MS/MS spectrum (preferably acquired in an ion trap or other fast mass analyzer) to determine if a product ion is present matching a characteristic product ion (e.g., the yion) of the isotopically-labeled peptide. If the characteristic product ion is present, then a HRAM MS/MS spectrum is acquired for detection and quantitation of the corresponding endogenous peptide.

US Patent:

20160035549, Feb 4, 2016

Filed:

Mar 7, 2014

Appl. No.:

14/776910

Inventors:

- San Jose CA, US
Justin BLETHROW - Oakland CA, US
Shannon Eliuk DIXON - San Jose CA, US
Tonya SECOND - Corona CA, US
Vladimir ZABROUSKOV - Belmont CA, US
Eric HEMENWAY - Milpitas CA, US

International Classification:

H01J 49/00

Abstract:

A hybrid mass spectrometer design and architecture, and methods of operating mass spectrometers are disclosed. According to one operating method, an analysis time is determined for each one of a plurality of ion species to be analyzed in an ordered sequence, and an injection time is calculated for at least some of the ion species based on an analysis time of a preceding ion species in the ordered list. The method enables more efficient utilization of analyzer time.