Shannon M Johnson

US Patent:

20230054841, Feb 23, 2023

Filed:

Jul 21, 2022

Appl. No.:

17/870807

Inventors:

- Cambridge MA, US
Shannon Leigh Johnson - Cambridge MA, US

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

C12N 15/01
C12Q 1/10
C12N 1/20
A61K 35/74

Abstract:

A method for directed exaptation includes dividing an original microorganism monoculture into subcultures that are subjected to different exaptation agents to obtain diversified substrains. At least one of the exaptation agents is selected to favor survival of sub strains exhibiting desired traits. The steps of dividing and subjecting may be iterated using at least some of the diversified substrains. Performance of diversified substrains is assessed and those that meet performance criteria for at least one desired trait are selected. Exaptation agents may include mutagenesis agents, training, horizontal gene transfer opportunities, and stressors. Substrains may be co-incubated with other living or dead microorganisms known to be preferentially adapted to have the desired trait. Diversified substrains may be combined into a multiculture microorganism population, to which microorganisms from the original monoculture may be added. The method may be used to create a treatment for a Multiple-Antibiotic Resistant Infection, preferably including a kill switch.

US Patent:

20210361863, Nov 25, 2021

Filed:

May 13, 2021

Appl. No.:

17/320057

Inventors:

- San Diego CA, US
Edward Stephen FERNER - Escondido CA, US
Beth A. SCHNEIDER - San Diego CA, US
Shannon John JOHNSON - Doral FL, US
Daniel M. ABAL - San Diego CA, US

International Classification:

A61M 5/172

Abstract:

A system and method for operating an analgesia administration system is disclosed. A control device is associated with a drug delivery device and configured to receive a first user input including at least a portion of a fingerprint of a patient, together with a second user input corresponding to a request to administer medication. The portion of the fingerprint is compared with previously-stored fingerprints to determine an identity of the patient and, in response to receiving the second user input and determining that the patient is an authorized user, one or more sensors are used to obtain one or more signals indicative of a state of the patient. If the state of the patient satisfies a set of medication delivery criteria, the drug delivery device is caused to administer a predefined amount of medication to the patient.

US Patent:

20210080472, Mar 18, 2021

Filed:

Sep 14, 2020

Appl. No.:

17/020803

Inventors:

- Cambridge MA, US
Shannon L. Johnson - Cambridge MA, US
Edward Stuart Boyden - Chestnut Hill MA, US

International Classification:

G01N 33/68
C07K 14/705
C12N 15/62

Abstract:

The invention, in some aspects, relates to the preparation and use of signaling reporter islands (SiRIs) in single cells. Compositions of the invention that produce SiRIs can be delivered to a cell resulting in the presence of one or more SiRIs in the cell. Methods of the invention include detecting signals generated by elements in the SiRIs in a cell and use of the detected signals to determine and analyze simultaneous physiological processes within the cell, or cells.