Joseph M. DeSimone - Chapel Hill NC, US Mary Napier - Chapel Hill NC, US Jin Wang - Houston TX, US Jing Xu - Chapel Hill NC, US Shaomin Tian - Chapel Hill NC, US Stuart Dunn - Carrboro NC, US
Assignee:
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL - Chapel Hill NC
International Classification:
C07D 207/46 C12N 15/113
US Classification:
536 245, 548542
Abstract:
Pharmaceutical, chemical and biological agents containing a reversible disulfide linker are described. These agents can also be covalently bound or contained in delivery vehicles for delivering the agents to desired targets or areas. Also described are delivery vehicles which contain an agent having a reversible disulfide linker and to vehicles that are covalently linked to the agent containing a reversible disulfide linker. The modifications described herein can modify properties of the agents and vehicles, thereby providing desired solubility, stability, hydrophobicity and targeting while the reversibility of the linker can leave the agent to which it is attached free from residual chemical groups after being reduced.
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