- Cambridge MA, US Gang Chen - Carlisle MA, US Xuanhe Zhao - Allston MA, US Elise M. Strobach - Clear Lake WI, US Bikramjit S. Bhatia - Cambridge MA, US Lin Zhao - Revere MA, US Sungwoo Yang - Chattanooga TN, US Lee A. Weinstein - Somerville MA, US Thomas A. Cooper - Boston MA, US Shaoting Lin - Cambridge MA, US
- Cambridge MA, US Hyunwoo Yuk - Cambridge MA, US Xinyue Liu - Cambridge MA, US Shaoting Lin - Cambridge MA, US German Alberto Parada Hermandez - Cambridge MA, US
International Classification:
A61M 31/00 A61F 5/00
Abstract:
An expandable hydrogel structure formed of a housing with a superabsorbent material disposed and sealed therein, particularly wherein the housing is fabricated of a hydrogel membrane with a plurality of macropores providing fluid communication between the superabsorbent material and an exterior of the housing. Exposure of the superabsorbent material to an expansion trigger expands the housing from an initial size to an expanded size that is at least about 50 times to at least about 100 times the initial size. One or more therapeutic agents can further be disposed within the housing to provide controlled release of the therapeutic agents from the expanded housing for extended periods.
- Cambridge MA, US Gang Chen - Carlisle MA, US Xuanhe Zhao - Allston MA, US Elise M. Strobach - Clear Lake WI, US Bikramjit S. Bhatia - Cambridge MA, US Lin Zhao - Revere MA, US Sungwoo Yang - Chattanooga TN, US Lee A. Weinstein - Somerville MA, US Thomas A. Cooper - Boston MA, US Shaoting Lin - Cambridge MA, US
- CAMBRIDGE MA, US Shaoting Lin - Cambridge MA, US Hyunwoo Yuk - Cambridge MA, US Teng Zhang - Cambridge MA, US German Alberto Parada - Cambridge MA, US
Assignee:
MASSACHUSETTS INSTITUTE OF TECHNOLOGY - CAMBRIDGE MA
Chemically anchoring long-chain polymer networks of tough hydrogels on solid surfaces can represent a general strategy to design tough and functional bonding between hydrogels and solid materials, achieving interfacial toughness over 1000 Jm.
Stretchable, Robust And Biocompatible Hydrogel Electronics And Devices
A tough biocompatible hydrogel having one or more drug delivery components, deformable conductors, and/or rigid electronic components incorporated therein in such a way that robust interfaces are formed between the hydrogel and the various components. The resulting hydrogel device provides a highly deformable hydrogel composite in which the reliability and functionality of the incorporated components are maintained even under states of large deformation, and from which one or more drugs can be delivered in a controlled and sustained manner regardless of the state of deformation.
Extremely Compliant Yet Tough Hydrogel Systems As Ultrasound Transmission Agents
- Cambridge MA, US Shaoting Lin - Cambridge MA, US Hyunwoo Yuk - Cambridge MA, US
International Classification:
B29C 71/00 A61K 49/22
Abstract:
Method for making a tough and compliant hydrogel. A precursor hydrogel is made of a first polymer selected to maintain high elasticity and a second polymer selected to dissipate mechanical energy. The precursor hydrogel is stretched to a multiple of its original length to form a pre-stretched hydrogel. The pre-stretched hydrogel is allowed to relax and is soaked in a biocompatible solvent to reach equilibrium swelling of the pre-stretched hydrogel whereby shear modulus of the hydrogel is reduced.
News
Band-Aid of the Future Lights Up, Delivers Medicine
Zhaos co-authors on the paper are graduate students Shaoting Lin, Hyunwoo Yuk, German Alberto Parada, postdoc Teng Zhang, Hyunwoo Koo from Samsung Display, and Cunjiang Yu from the University of Houston.